A5100392684- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Liver Disease and Transplantation
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Tea Polyphenols and Effects
- Cancer Immunotherapy and Biomarkers
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Systemic Sclerosis and Related Diseases
- Connective Tissue Growth Factor Research
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Diet and metabolism studies
- Gut microbiota and health
- Spine and Intervertebral Disc Pathology
- Reproductive tract infections research
- Invertebrate Immune Response Mechanisms
- Gastrointestinal motility and disorders
- Energy Load and Power Forecasting
- Toxoplasma gondii Research Studies
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Guangzhou University
2024-2025
Sun Yat-sen University
2024-2025
Zhongshan Hospital
2024-2025
Shandong First Medical University
2023-2025
Fudan University
2025
Shandong Provincial QianFoShan Hospital
2023-2025
Shandong University
2023-2025
Children's Hospital of Pittsburgh
2025
Changchun University of Chinese Medicine
2022-2024
Abstract Glycolysis, as an altered cancer cell-intrinsic metabolism, is essential hallmark of cancer. Phosphofructokinase (PFK) a metabolic sensor in the glycolytic pathway and restricting substrate availability for this enzyme has been researched extensively target chemotherapy. In present study, we investigated that effects epigallocatechin-3-gallate (EGCG), active component green tea, on inhibiting cell growth inducing apoptosis by promoting shift away from glycolysis aerobic...
Aberration of the "gut-liver axis" contributes to development and progression metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we use multi-omics analyze gut microbiota composition profile patients with type-2 diabetes mellitus (T2DM). T2DM were screened for by blood tests, ultrasound, stiffness measurements. Stool was analyzed 16S rRNA gene sequencing; metabolomic profiling Nuclear Magnetic Resonance spectroscopy Ultra-High Performance-Mass Spectrometry. Microbiome...
PANoptosis is one of several modes programmed cell death (PCD) and plays an important role in many inflammatory immune diseases. The bowel disease (IBD) currently unknown. Differentially expressed PANoptosis-related genes (DE-PRGs) were identified, pathway enrichment analyses performed. LASSO regression model construction, a nomogram model, calibration curves, ROC DCA curves used to evaluate the predictive value model. Predicts transcription factors (TFs) small-molecule drugs DE-PRGs...
Checkpoint inhibitor-related hepatitis (CPI-Hep) is an emerging clinical challenge. We aimed to gain insights into the immunopathology of CPI-Hep by comprehensively characterising myeloid and lymphoid subsets.
Background: Epigallocatechin-3-gallate (EGCG) is the most effective compound in green tea, and possesses a wide range of beneficial effects, including anti-inflammatory, antioxidant, antiobesity, anticancer effects. In this study, we investigated protective effects EGCG concanavalin A (ConA)-induced hepatitis mice explored possible mechanisms involved these Methods: Balb/C were injected with ConA (25 mg/kg) to induce acute autoimmune hepatitis, (10 or 30 was administered orally twice daily...
Abstract Host immune responses are tightly controlled by various factors during infection, and protozoan parasites also manipulate the system to evade surveillance, leading an evolutionary arms race in host‒pathogen interactions; however, underlying mechanisms not fully understood. We observed that level of superoxide dismutase 3 (SOD3) was significantly elevated both Plasmodium falciparum malaria patients mice infected with four parasite species. SOD3-deficient had a substantially longer...
As of February 2017, approximately 7639 amphibian species have been described in the AmphibiaWeb database. However, only 20 cathelicidin-like antimicrobial peptides identified to date from 10 species. Half these were genome sequences and not yet functionally characterized. In this study, a novel peptide designated cathelicidin-PP was purified skin tree frog Polypedates puerensis. Cathelicidin-PP is 32 residue sequence ASENGKCNLLCLVKKKLRAVGNVIKTVVGKIA. Circular dichroism spectroscopy...
To establish a graded method to avoid mean fluorescence intensity (MFI) threshold of HLA Class I antibodies corresponding antigen, and the HLAMatchmaker program has been used select minimum mismatch value donor-patient epitopes. Evaluate application combining both methods in selecting compatible platelets (PTL) for patients with immune platelet transfusion failure (IPTR) improving corrected count increment (CCI).
The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. expression 41 proteins was significantly altered the inflamed spinal cord. Twenty these are implicated EAE first time many have previously been shown play a role antigen processing, inflammation, neuroprotection, or neurodegeneration. Keywords: • sclerosis iTRAQ mass spectrometry cord
Purpose: Cisplatin (DDP) based chemotherapy regimens are widely used in advanced gastric cancer (GC). Drug resistance often limited the clinical benefits of cisplatin regimen. The mechanisms have not been fully revealed. Therefore, further exploration relevant molecular is urgently needed. Patients and methods: DDP associated miRNA GC microarray dataset GSE86195 was obtained from National Center for Biotechnology Information (NCBI) GEO database, GEO2R applied to compare samples two different...
ABSTRACT This study aimed to clarify the role and mechanism of tetrahedral framework nucleic acids (tFNAs) in regulating M2 macrophages reduce intestinal injury. An injury model was established by intraperitoneal injection lipopolysaccharides (LPS) mice explore alleviating effects tFNAs on Inflammatory factors were detected quantitative polymerase chain reaction (qPCR) enzyme‐linked immunosorbent assay (ELISA). The barrier permeability assessed using western blotting immunohistochemistry....
Tumor local and distant relapse recurrence after radiotherapy (RT) is one of the critical factors leading to poor prognosis. The effective antitumor effects RT are dependent upon participation innate adaptive components immune system. C5a/C5aR1 signaling can regulate effect in tumor microenvironment (TME). Thus, exploring changes mechanism TME induced by RT-mediated complement activation may provide a novel perspective for reversing radioresistance.First, fractionated radiation 8 Gy ×3...
Summary Background The prevalence, prediction and impact of acute kidney injury (AKI) in alcohol‐related hepatitis (AH) is uncertain. Aims We aimed to determine AKI incidence; association with mortality; evaluate serum biomarkers the modifying effects prednisolone pentoxifylline largest AH cohort date. Methods Participants Steroids or Pentoxifylline for Alcoholic Hepatitis trial day zero (D0) creatinine available were included. was defined by modified International Club Ascites criteria;...
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Although (−)-epigallocatechin-3-gallate (EGCG) exhibits various bioactivities, its low bioavailability and toxicity at high concentrations limit application. Microbial biotransformation of EGCG could improve but the interplay between EGCG-transforming microbes was little known. Here, 50 g/L or less completely degraded 48 h when co-incubated with Aspergillus niger RAF106 in potato dextrose broth. The degradation accompanied by an unchanged radical-scavenging activity increase production...
Black flies (Diptera: Simuliidae) are haematophagous insects that can cause allergic reactions and act as vectors of pathogens. Although their saliva has been thought to contain a diverse array physiologically active molecules, little information is available on antimicrobial factors in black fly salivary glands, especially no defensins have reported so far. A novel cationic defensin designated SibaDef was purified using reverse phase high-performance liquid chromatography (RP-HPLC) from the...