A5100670138- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- 3D Printing in Biomedical Research
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Berberine and alkaloids research
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
- Redox biology and oxidative stress
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Surface Modification and Superhydrophobicity
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Wuxi People's Hospital
2018-2023
Nanjing Medical University
2013-2023
Yunnan Agricultural University
2022
Xichang University
2022
Suzhou Municipal Hospital
2021
Wuxi Institute of Technology
2019
Lishui Central Hospital
2019
National Natural Science Foundation of China
2018
Creative Commons
2018
Patients with persistent ulcerative colitis (UC) are at a higher risk of developing colitis-associated cancer (CAC). Previous studies have reported that intestinal microbiota disturbance plays an important role in the process CAC development patients UC, indicating targeted intervention and its metabolites may be potential therapeutic strategy. Gut colorectal UC was analyzed using gutMEGA database verified fecal samples. The abundance Bacteroides fragilis reduced significantly associated...
Non-toxic, safe materials and preparation methods are among the most important factors when designing nanoparticles (NPs) for future clinical application. Here we report a novel facile method encapsulating anticancer drug paclitaxel (PTX) into silk fibroin (SF), biocompatible biodegradable natural polymer, without adding any toxic organic solvents, surfactants or other agents. The loaded (PTX-SF-NPs) with diameter of 130 nm were formed in an aqueous solution at room temperature by...
To discover and screen the constituents or metabolites absorbed into blood after oral administration of herbal medicines tends to be more difficult. In this work, an integrative pattern recognition approach principal component analysis (PCA) orthogonal partial least squared discriminant (OPLS-DA) was successfully applied for rapid discovery natural compounds from medicines. A rapid, sensitive, reliable ultra performance liquid chromatography coupled with electrospray...
BackgroundAs a common malignant disease in females, breast cancer (BCa) causes increasing numbers of cancer-related death. Collagen X alpha 1 chain (COL10A1) plays critical role the oncogenesis and progression tumors. However, systematic analysis COL10A1 BCa has not been conducted.MethodsThe expression level prognostic value were defined through Cancer Genome Atlas (TCGA) as well Kaplan-Meier plotter data respectively. The pattern was subsequently confirmed on tissue microarray (TMA) by...
Pharmacognosy Magazine,2016,12,45,41-49.DOI:10.4103/0973-1296.176023Published:February 2016Type:Original ArticleAuthors:Hui Sun, Huiyu Wang, Aihua Zhang, Guangli Yan, Ying Han, Yuan Li, Xiuhong Wu, Xiangcai Meng, and Xijun Wang Author(s) affiliations:Hui Department of Pharmaceutical Analysis, National TCM Key Laboratory Serum Pharmacochemistry, Metabolomics Chinmedomics, Heilongjiang University Chinese Medicine, Harbin 150040, China Abstract:Background: As herbal medicines have an important...
Abstract Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, family of nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases, have emerged as key regulators cellular metabolism, stress responses, the aging process, serving energy status sensors in response CR. However, mechanism through which CR regulates Sirtuin function...
Conventional in vitro circulating tumor cell (CTC) detection methods are always limited by blood sample volume because of the requirement a large amount blood. The aim this study was to overcome limitation designing and making an vivo CTC capture device. In study, we designed prepared kind proper material serve purpose intervention. A method employing 3-aminopropyltriethoxysilane (γ-APS) as coupling reagent graft carboxybetaine methacrylate (CBMA) immobilize anti-epithelial adhesion...
Abstract Background The peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers the prognostic values several have evaluated already. Purpose our research is explore expression profiles PRDXs breast cancer (BrCa). Methods transcriptional levels PDRX members primary BrCa tissues their association with intrinsic subclasses were analyzed using UALCAN database. Then, genetic alterations PDRXs examined by cBioPortal Moreover,...
The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of oncogenesis. current research aimed to explore relationship between BRCA1 expression, prognosis, immunity in hepatocellular carcinoma (HCC). In this study, expression was analyzed via multiple online databases its association with clinical characteristics, prognosis genetic alterations identified using original Cancer Genome Atlas-liver cohorts. DNA methylation sites...
In recent years, immunotherapies have emerged as effective therapeutic strategies for treating human cancers. However, accumulating evidence has revealed an inconsistency between the response to immune checkpoint inhibitors and programmed death ligand 1 (PD-L1) expression status detected by immunohistochemistry staining. Recent research that removal of N-Linked glycosylation significantly enhanced PD-L1 detection, resulting in both more accurate quantification clinical outcome prediction....
Abstract Solute carrier family 16, member 12 (SLC16A12) is a highly -expressed protein in the kidney and has been reported to participate transport of creatine. However, clinical values SLC16A12 clear cell renal carcinoma (ccRCC) have not explored. RNA-seq data information were downloaded from Cancer Genome Atlas (TCGA) database. We compared its expression ccRCC paracancerous tissues, then result was further validated with our cohort. The impact on significance also assessed. Compared...
Adipose tissues (ATs), including visceral ATs (VATs) and subcutaneous (SATs), are crucial for maintaining energy metabolic homeostasis. SATs have been found to be closely related obesity obesity-induced disease. Some studies shown a significant association between fat metabolism sexes. However, the molecular mechanisms this still unclear. Here, using pig as model, we investigated systematic sexes, identified some key sex-specific pathways genes in from pigs.The results revealed that 134...
The capture of circulating tumor cells (CTCs) plays a crucial role in the early diagnosis, personalized treatment and postoperative evaluation malignant tumors. In this study, UV-curable coating technology was combined with antibody immobilization to enable CTC captures on poly(methyl methacrylate) (PMMA) substrates. Controlled amounts carboxyl groups polyethylene glycol (PEG) segments were introduced into formulation facilitate antibodies block non-specific protein adsorption, respectively....
Evidence has indicated that endothelin-1 is related to the pathogenesis of hypertension. To characterize role (ET-1) in development pulmonary hypertension syndrome broilers, blockade effect ETA receptor (ETA) antagonist, BQ123, on blood pressure experimental models was examined. Birds were locally anesthetized and instrumented with venous catheters for arterial (PAP) right ventricular (RVP), followed by packed cell volume (PCV) Ascites heart index (AHI) measured, after exposed low ambient...
Abstract Photodynamic therapy (PDT) is a promising method for neoplastic and nonneoplastic diseases. In this study, we utilized sinoporphyrin sodium (DVDMS) as sensitizer combined with light to investigate its cytotoxic effect on different cell lines. For purpose, chose bovine serum albumin (BSA) model explore the mechanism of PDT-induced death at molecular level. Our findings indicated that treatment significantly suppressed survival. Fluorescence spectroscopy revealed strong interaction...