A5100397529- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Renal and related cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Intraperitoneal and Appendiceal Malignancies
- Ferroptosis and cancer prognosis
- Pediatric Urology and Nephrology Studies
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Colorectal and Anal Carcinomas
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Esophageal Cancer Research and Treatment
- Economic and Financial Impacts of Cancer
- CAR-T cell therapy research
Nanjing Drum Tower Hospital
2015-2025
United Imaging Healthcare (China)
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Fujian Provincial Cancer Hospital
2024
Sichuan University
2021-2024
West China Medical Center of Sichuan University
2021-2024
Nanjing University of Chinese Medicine
2024
Chinese PLA General Hospital
2022-2024
PLA Academy of Military Science
2022-2024
Credo Reference (United States)
2024
In this multicenter, single-arm phase 2 trial (ChiCTR1900024428), patients with locally advanced gastric/gastroesophageal junction cancers receive one cycle of sintilimab (anti-PD1) and chemotherapy (S-1 nab-paclitaxel), followed by 5 weeks concurrent chemoradiotherapy sintilimab, another thereafter. Surgery is preferably scheduled within to three weeks, cycles adjuvant are administrated. The primary endpoint the pathological complete response. Our results meet pre-specified endpoint....
Abnormalities in the KEPA1-NRF2 pathway have a role cancer progression, metastasis, and resistance to chemo- radiotherapies. Persistent activation of NRF2 associates with poor prognosis across different types. However, beneficial therapeutic strategy harness this remains unclear. This study aimed investigate clinical outcome immunotherapy NFE2L2/KEAP1 mutant population.We investigated correlation between mutations tumor mutational burden (TMB) programmed death-ligand 1 (PD-L1) expression...
Risk factors and mechanisms of cognitive impairment (CI) after aneurysmal subarachnoid hemorrhage (aSAH) are unclear. This study used a neuropsychological battery, MRI, ERP CSF plasma biomarkers to predict long-term aSAH. 214 patients hospitalized with aSAH (n = 125) or unruptured intracranial aneurysms (UIA) 89) were included in this prospective cohort study. Neuropsychological tests administered 7 24 months post-discharge. ERP, CI, area under ROC curves calculated. Patients CI showed...
The body mass index (BMI), as an easy-to-calculate measure of fatness, is closely associated with all-cause mortality, but few studies a large enough scale have examined the relationship between BMI and quality life. A comprehensive precise insight into new range needed. Based on ChinaHEART (Health Evaluation And risk Reduction through nationwide Teamwork), nationwide, population-based cohort study, 4,485,773 participants living in 20,159 communities or villages were passively followed for...
N 6 ‐methyladenosine (m A) is the most abundant RNA modification in mammalian cells, and has emerged as an important player tumour development through post‐transcriptional gene regulation. In this study, we found that m A reader protein IGF2BP3 was upregulated modifier bladder cancer proteomic analysis of 17 pairs human tissues adjacent normal tissues, for which expression also positively correlated with higher stage poorer prognosis. vitro vivo assays demonstrated powerful oncogenic...
Conventional in vitro circulating tumor cell (CTC) detection methods are always limited by blood sample volume because of the requirement a large amount blood. The aim this study was to overcome limitation designing and making an vivo CTC capture device. In study, we designed prepared kind proper material serve purpose intervention. A method employing 3-aminopropyltriethoxysilane (γ-APS) as coupling reagent graft carboxybetaine methacrylate (CBMA) immobilize anti-epithelial adhesion...
To investigate the efficacy of surgery in treatment metastatic renal cell carcinoma (mRCC) and to identify prognostic factors.A single center retrospective study 96 patients with mRCC from December 2004 August 2013.The median follow-up time was 45 months. Thirty-one (32.3%) received complete resection sites, 11 (11.5%) underwent incomplete 54 (56.3%) no surgery. In univariate Kaplan-Meier analysis, overall survival times three groups were 52 months, 16 22 respectively (p < 0.001). The...
Purpose: This study aimed to compare the safety and effectiveness of MP1000 surgical system with da Vinci ® Si robot in robot-assisted partial nephrectomy (RAPN) through a prospective, single-blinded, randomized control trial. Materials Methods: A total 62 patients who were scheduled undergo RAPN randomly assigned either Vinci® or group. noninferiority test was conducted non-inferior intermediate value 10%. The compared installation operation times, estimated blood loss, warm ischemia time,...
// Yang 1, 2 , Xiaoyan Shen 1 Rutian Li Jie Hang Zhang Lixia Yu Baorui Liu and Lifeng Wang The Comprehensive Cancer Center of Drum Tower Hospital, Nanjing University Medical School Clinical Institute University, 210008, PR China Xianlin 210046, Correspondence to: Wang, email: lifengwang@nju.edu.cn Keywords: NSCLC, cfDNA, CastPCR, driver mutation, EGFR Received: September 16, 2016 Accepted: May 04, 2017 Published: 17, ABSTRACT Objective: Although mutation status is crucial to targeted therapy...
To evaluate choroidal vascularity index (CVI) in eyes with internal carotid artery (ICA) stenosis using binarization tool enhanced depth images scanned by spectral domain optical coherence tomography.A retrospective cohort study was conducted 142 patients ICA stenosis, and 20 normal control subjects matched the age, sex, etc. According to diagnostic criteria, participants are divided into a group (20 cases), mild (64 moderate (61 severe (17 cases). Enhanced imaging tomography (EDIOCT)...
Transcription factor SOX9 was a biomarker for prostate cancer (Pca) with poor prognosis. Nevertheless, the regulatory mechanism underlying upregulation still remains unclear. Several cytokines have been reported to be involved in regulation of SOX9, suggesting that cancer‐associated fibroblasts (CAFs), one main sources secreted factors tumor microenvironment (TME), may play role regulating expression. Herein, an vitro model paracrine interaction between primary CAFs and Pca cells applied...
Objective. Renal cell carcinoma (RCC) is a heterogeneous disease comprising histologically defined subtypes among which clear RCC (ccRCC) accounts for 70% of all cases. DNA methylation constitutes main part the molecular mechanism cancer evolution and prognosis. In this study, we aim to identify differentially methylated genes related ccRCC their prognostic values. Methods. The GSE168845 dataset was downloaded from Gene Expression Omnibus (GEO) database expressed (DEGs) between tissues...
Predictive biomarkers based individualized chemotherapy can improve efficacy.However, for those advanced patients, it may be impossible to obtain the tissues from operation.Tissues biopsy not always enough gene detection.Thus, biomarker blood could a non-invasive and useful tool provide real-time information in procedure of treatment.To further understand role plasma mRNA chemo-efficiency prediction, several expression levels were assessed paired tumor 133 locally gastric cancer patients...
Recent research has suggested that certain plant-derived polyphenols, i.e., ursolic acid (UA), which are reported to have antitumor activities, might be used sensitize tumor cells radiation therapy by inhibiting pathways leading resistance. This experiment was designed investigate the effects and possible mechanism of radiosensitization UA in BGC-823 cell line from human adenocarcinoma gastric cancer vitro. caused cytotoxicity a dose-dependent manner, we sub-cytotoxicity concentration test...
The diagnosis of Xp11.2 translocation renal cell carcinoma (tRCC), which relies on morphology and immunohistochemistry (IHC), is often either missed in the or misdiagnosed. To improve accuracy tRCC ASPL-TFE3 (RCC), we investigated newly designed fluorescence situ hybridization (FISH) probes (diagnostic study).Based genetic characteristics RCC, a new break-apart TFE3 FISH probe an dual-fusion were applied to 65 patients with RCC who <45 years old showed suspicious microscopic features our...
Abstract Background Stage IV gastric signet ring cell carcinoma (SRCC) is a type of malignant cancer (GC) with poorer survival compared to metastatic non‐SRCC (NOS). However, chemotherapy alone was unable maintain long‐term survival. This study aimed evaluate benefit palliative gastrectomy plus (PG+C) for SRCC. Methods We obtained data on patients between 2010 and 2015 from the Surveillance, Epidemiology, End Results (SEER) database. Statistical methods included χ 2 tests, Kaplan‐Meier...
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are considered to be effective treatments for advanced non-small cell lung cancer (NSCLC) patients with sensitizing EGFR mutations, including exon 19 deletion and 21 L858R mutations. However, the development of mutation detection assays, complex mutations emerging, their response EGFR-TKIs remains unclear. The present study reports a case 62-year-old, non-smoking female patient NSCLC, presenting concurrent 19+21 who had...
Gastric cancer is the fifth leading cause of cancer-related mortality worldwide, with a low 5-year survival rate in advanced stages. Cutaneous metastasis rare gastric cancer, only 0.8-1% incidence. We reported case female cancer. The patient had undergone subtotal gastrectomy and chemotherapy 13 years ago, followed by subsequent surgery residual stomach, partial jejunum, colon resection 11 later. pathological examination revealed poorly differentiated stomach adenocarcinoma, Lauren...
4040 Background: PD-1 inhibitor and chemotherapy have shown significant clinical benefits in 1L-treatment of G/GEJ. While it is not clear for locally advanced stage. The aim this single-arm phase Ib trial to assess the feasibility sintilimab (PD-1 inhibitor) combination with cCRT GC. Methods: Patients (pts) initial histopathologically confirmed G/GEJ adenocarcinoma, diagnosed as III-IVA per AJCC 8 th ECOG PS 0-1 were eligible. Sintilimab (200mg, iv, Q3W) was given CRT sandwich sequence one...
Epithelial growth factor receptor (EGFR)-tyrosine kinase inhibitors are the standard first-line treatment for patients with metastatic non-small cell lung cancer (NSCLC) expressing sensitive EGFR-mutants. Other drugs target different driver mutants, including serine/threonine-protein B-raf (BRAF) inhibitor dabrafenib, which has exhibited promising efficacy treating BRAF-mutated NSCLC. Therefore, identifying carrying mutations that may be treated using targeted therapies is important....