A5102003590- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Respiratory Support and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Respiratory viral infections research
- Connective Tissue Growth Factor Research
- Cancer-related gene regulation
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Shanxi Academy of Medical Sciences
2022-2025
Shanxi Medical University
2022-2025
National Clinical Research Center for Digestive Diseases
2017-2023
National Health and Family Planning Commission
2015-2023
Shenzhen Second People's Hospital
2021-2023
State Key Laboratory of Respiratory Disease
2023
Jiujiang First People's Hospital
2022
Anhui Medical University
2020
In December 2019, the coronavirus disease 2019 (COVID-19) outbreak occurred in Wuhan. Data on clinical characteristics and outcomes of patients with severe COVID-19 are limited.We sought to evaluate severity admission, complications, treatment, COVID-19.Patients admitted Tongji Hospital from January 26, 2020, February 5, were retrospectively enrolled followed-up until March 3, 2020. Potential risk factors for analyzed by a multivariable binary logistic model. Cox proportional hazard...
Abstract Objective To describe the temporal and spatial trends of mortality disability adjusted life years (DALYs) due to chronic respiratory diseases, by age sex, across world during 1990-2017 using data from Global Burden Disease Study 2017. Design Systematic analysis. Data source The Diseases, Injuries, Risk Factors Methods Mortality DALYs diseases were estimated 2017 DisMod-MR 2.1, a Bayesian meta-regression tool. annual percentage change standardised rate was calculated generalised...
Chronic respiratory diseases (CRDs) are leading causes of morbidity worldwide. However, the spatial and temporal trends in prevalence incidence CRDs have not been estimated.Based on data from Global Burden Diseases, Injuries, Risk Factors Study 2017, we analyzed 1990 to 2017 according age, sex, region disease pattern. Furthermore, correlations between World Bank income levels, sociodemographic index (SDI), human development (HDI) levels were assess factors affecting incidence.The total...
The rapid outbreak of coronavirus disease 2019 (COVID-19) has turned into a public health emergency international concern. Epidemiological research shown that sex is associated with the severity COVID-19, but underlying mechanism predisposition remains poorly understood. We aim to study gendered differences in inflammation reaction, and association mortality COVID-19.In this retrospective study, we enrolled 548 COVID-19 inpatients from Tongji Hospital 26 January 5 February 2020, followed up...
Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate potential risk factors. Clinical data during hospitalization at a mean (SD) day 249 (15) days after discharge from 40 survivors confirmed (including 25 severe cases) were collected analyzed retrospectively. At follow-up, cases had higher incidences persistent symptoms, DLCO impairment, abnormal CT score as compared mild cases. follow-up was positively correlated age, LDH level, cumulative oxygen...
Hypoxic pulmonary hypertension (HPH) is characterized by active vasoconstriction and profound vascular remodeling. KLF5, a zinc-finger transcription factor, involved in the excessive proliferation apoptotic resistance phenotype associated with monocrotaline-induced hypertension. However, molecular mechanisms of KLF5-mediated pathogenesis HPH are largely undefined. Adult male Sprague-Dawley rats were exposed to normoxia or hypoxia (10% O 2 ) for 4 wk. developed arterial remodeling right...
Transcription factor Krüppel-like factors 5 (KLF5) is overexpressed in a wide range of tumor tissues and acts as prognostic cancer. However, the role KLF5 non-small cell lung cancer not clear. Hypoxia plays vital part development via hypoxia-inducible 1 (HIF-1). Our study showed that hypoxia (1% O2) increased viability, clonality proliferation inhibited apoptosis A549 cells. The expression HIF-1α was time-dependently hypoxia. Using small interfering RNA (siRNA) targeting or HIF-1α, we...
Abstract Objectives We aimed to gain an understanding of the paradox immunity in COVID‐19 patients with T cells showing both functional defects and hyperactivation enhanced proliferation. Methods A total 280 hospitalised were evaluated for cytokine profiles clinical features including viral shedding. mouse model acute infection by lymphocytic choriomeningitis virus (LCMV) was applied dissect relationship between immunological, virological pathological features. The results from validated...
Hypoxic pulmonary hypertension (HPH) is a chronic progressive advanced disorder pathologically characterized by vascular remodeling. Notch4 as cell surface receptor critical for development. However, little known about the role and mechanism of in development hypoxic remodeling.Lung tissue samples were collected to detect expression from patients with HPH matched controls. Human artery smooth muscle cells (HPASMCs) cultured normoxic conditions. Real-time quantitative PCR western blotting...
BACKGROUND:The rapid worldwide spread of the coronavirus disease 2019 (COVID-19) epidemic has placed patients with pre-existing conditions at risk severe morbidity and mortality. The present study investigated clinical characteristics outcomes COVID-19 chronic obstructive pulmonary (COPD). MATERIAL AND METHODS:This enrolled 336 consecutive confirmed COVID-19, including 28 diagnosed COPD, from January 20, 2020, to April 1, 2020. Demographic data, symptoms, laboratory values, comorbidities,...
Objective To investigate the relationship between eosinophil (EOS) and CT imaging, we quantitatively evaluated bronchial wall thickening, emphysema index (EI) pulmonary vascular parameters in patients with chronic obstructive disease (COPD) based on different EOS levels. Design Retrospective observational study. Setting A tertiary hospital China. Participants 448 COPD from January 2020 to 2023. Main outcome measures Laboratory data, chest function levels: <150/µL, ≥150/µL; <100/µL,...
Gefitinib exhibits significant clinical efficacy in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) sensitive mutations. However, its is severely limited by acquired resistance. Herein, we designed and synthesized a series of dual-targeting thioredoxin reductase (TrxR)-EGFR gold complexes attaching ligand to the parent structure gefitinib, 4-anilinoquinazoline. Among them, L1Au2 exhibited activity against both gefitinib-sensitive resistant...
Abstract: Erectile dysfunction (ED) is a frequent occurrence in male patients with obstructive sleep apnea syndrome (OSAS). Long‐term intermittent hypoxia (LTIH), one of the hallmarks OSAS, could mediate ED. The objective this study was to test hypothesis that increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity contributes ED rat responses LTIH. Healthy Sprague‐Dawley rats were randomly distributed into 4 groups: LTIH group, an apocynin (a selective NADPH...
Neutrophilic asthmatics (NA) have less response to inhaled corticosteroids. We aimed find out the predictor of treatment in NA.Asthmatics (n = 115) and healthy controls 28) underwent clinical assessment during 6-month follow-up with standardized therapy. Asthmatics were categorized by sputum differential cell count. The mRNA expressions measured RT-qPCR for cytokines (IFN-γ, IL-1β, IL-27, FOXP3, IL-17A, IL-5). protein IL-1β supernatant was detected ELISA. Reticular basement membranes (RBM)...
Background: Regulation or restoration of therapeutic sensitivity to glucocorticoids is important in patients with steroid-resistant asthma. Spleen tyrosine kinase (Syk) activated at high levels asthma and mouse models, small-molecule Syk inhibitors such as R406 show potent anti-inflammatory effects the treatment immune inflammatory diseases. Several downstream signaling molecules are involved glucocorticoid response, so we hypothesized that could restore dexamethasone severe Objective: To...