A5100648462- Liver Disease Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Cell death mechanisms and regulation
- Diet, Metabolism, and Disease
- NF-κB Signaling Pathways
- Liver Disease and Transplantation
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Sleep and Wakefulness Research
- Virus-based gene therapy research
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Uterine Myomas and Treatments
- Endoplasmic Reticulum Stress and Disease
- Advanced Chemical Sensor Technologies
- Bone health and treatments
- Alkaline Phosphatase Research Studies
- interferon and immune responses
- Heterotopic Ossification and Related Conditions
- Endometrial and Cervical Cancer Treatments
- Obstructive Sleep Apnea Research
- Animal Genetics and Reproduction
- Radiation Therapy and Dosimetry
- Endometriosis Research and Treatment
- Cardiovascular Disease and Adiposity
Huazhong University of Science and Technology
2004-2024
Tongji Hospital
2004-2024
Hubei Zhongshan Hospital
2024
Wuhan University
2024
Union Hospital
2017-2021
Central Hospital of Wuhan
2019-2021
Union Hospital
2020
The gut-liver axis is associated with the progression of non-alcoholic fatty liver disease (NAFLD). Targeting and bile acid-based pharmaceuticals are potential therapies for NAFLD. effect tauroursodeoxycholic acid (TUDCA), a candidate drug NAFLD, on intestinal barrier function, inflammation, gut lipid transport microbiota composition was analysed in murine model NAFLD.The NAFLD mouse established by feeding mice high-fat diet (HFD) 16 weeks. TUDCA administered p.o. during last 4 expression...
Hepatic ischemia/reperfusion (I/R) is a major challenge for liver surgery and specific severe conditions of chronic disease. Current surgical pharmacological strategies are limited to improve function after hepatic I/R injury. Thus, an in-depth understanding the mechanism pivotal develop new therapeutic methods. The cellular repressor E1A-stimulated genes (Creg), key regulator proliferation, exerts protective roles in cardiovascular diseases participates lipid accumulation inflammatory...
IMA-1 targets the ALOX12-ACC1 interaction to both prevent and treat NASH without inducing hyperlipidemia.
The fermentation of oolong tea is a critical process that determines its quality and flavor. Current control relies on makers’ sensory experience, which labor-intensive time-consuming. In this study, using Tieguanyin as the research object, features including water loss rate, aroma, image color, texture were obtained weight sensors, tin oxide-type gas sensor, visual acquisition system. Support vector regression (SVR), random forest (RF) machine learning, long short-term memory (LSTM) deep...
Abstract: Erectile dysfunction (ED) is a frequent occurrence in male patients with obstructive sleep apnea syndrome (OSAS). Long‐term intermittent hypoxia (LTIH), one of the hallmarks OSAS, could mediate ED. The objective this study was to test hypothesis that increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity contributes ED rat responses LTIH. Healthy Sprague‐Dawley rats were randomly distributed into 4 groups: LTIH group, an apocynin (a selective NADPH...
CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in a variety of tumors. Nevertheless, whether CXCR7 can be used as tumor prognosis marker has not been systematically assessed. The current meta-analysis was performed to obtain an accurate evaluation the relationship between level and cancer patients.Embase, Web Science, PubMed were searched according defined search strategy up June 11, 2018. Then, required data extracted from all qualified studies which screened out based on...
ABSTRACT Actin cytoskeleton has been shown to play a regulating role in several signaling pathways, and disruption of actin filament reported increase sTNF-α-induced cell death. However, whether is involved tmTNF-α-mediated cytotoxicity remains unclear. Here, we demonstrated that pretreatment HL-60 with CytD or LatA depolymerize significantly suppressed apoptosis. Interestingly, tmTNF-α increased the immunoprecipitated by anti-TNFR2 but not anti-TNFR1 antibody, totally blocked this effect....
OBJECTIVES: The goal of our study was to assess the prognostic impact necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy hepatocellular carcinoma (HCC) patients. METHODS: In this study, expression its polymorphism(rs2272990) were examined plasma 44 HCC All these patients undergoing partial hepatectomy. values for tumor development survival, further determined. RESULTS: Plasma expressions significantly increased patients,...
This study aimed to investigate the effect of endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) on sonic hedgehog N-terminus (N-Shh)-enhanced-osteogenic differentiation process in mouse embryonic fibroblasts (MEFs).
Objective To compare the fracture risk in postmenopausal Asian women with or without type 2 diabetes mellitus (T2DM). Methods The study cohort comprised data from consecutive T2DM that were retrieved a prospectively maintained institutional database 2001 to 2009. Postmenopausal DM Medical Examination Center 2009 formed control cohort. primary endpoint was World Health Organization Fracture Risk Algorithm (FRAX, revised 2013) score. secondary bone mineral density (BMD). Results There 1014...
Abstract Background The purpose of this study was to assess the efficacy and safety cisplatin-based chemotherapy with or without bevacizumab (BEV) in Chinese women advanced cervical cancer (ACC). Methods For observational study, we analysed data 316 ACC who were treated at Henan provincial people’s hospital between Jan 1, 2014, Dec 31, 2018, plus BEV (CB) alone (CA) until disease progression, unacceptable toxicity, death. co-primary endpoints overall survival (OS) progression-free (PFS);...
Non-specific ST-T segment changes are prevalent and proven risk factors for early onset of cardiovascular diseases. They can increase all-cause mortality by 100∼200% candidate signs changes. Nonalcoholic fatty liver disease (NAFLD) is worldwide one facet a multisystem that confers substantial increases morbidity nonalcoholic liver-related It unclear whether NAFLD associated with non-specific warning Therefore, we investigated this association.A cross-sectional study was designed included...
Anxi Tieguanyin belongs to the oolong tea category and is one of top ten most famous teas in China. In this study, hyperspectral imaging (HSI) technology was combined with chemometric methods achieve rapid determination free amino acid polyphenol contents tea. Here, spectral data samples four quality grades were obtained via visible near-infrared hyperspectroscopy range 400–1000 nm, detected. First derivative (1D), normalization (Nor), Savitzky–Golay (SG) smoothing utilized preprocess...