A5021171443- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Plant Reproductive Biology
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- NF-κB Signaling Pathways
- Hepatitis C virus research
- Lipid metabolism and biosynthesis
- RNA regulation and disease
- COVID-19 Clinical Research Studies
- Cardiovascular Health and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Ubiquitin and proteasome pathways
- Alcohol Consumption and Health Effects
- Air Quality and Health Impacts
- Pancreatic function and diabetes
- Plant Molecular Biology Research
- Climate Change and Health Impacts
Wuhan University
2014-2024
Zhongnan Hospital of Wuhan University
2018-2024
Renmin Hospital of Wuhan University
2016-2023
Model Animal Research Center
2020-2021
Central South University
2020
Medical Research Institute
2017
Tongji Hospital
2016-2017
Huazhong University of Science and Technology
2016-2017
Zhongda Hospital Southeast University
2016
State Key Laboratory of Hybrid Rice
2013-2014
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
Abstract The cytoplasmic male sterility (CMS) phenotype in plants can be reversed by the action of nuclear-encoded fertility restorer (Rf) genes. molecular mechanism involved Rf gene–mediated processing CMS-associated transcripts is unclear, as are identities other proteins that may CMS–Rf interaction. In this study, we cloned gene Rf5 for Hong-Lian CMS rice and studied its restoration with respect to transcript atp6-orfH79. RF5, a pentatricopeptide repeat (PPR) protein, was unable bind...
Nonalcoholic liver disease (NAFLD) encompasses a continuum from simple steatosis, to non-alcoholic steatohepatitis (NASH). However, there are currently no approved pharmacotherapies for NAFLD although several drugs in advanced stages of clinical development. Because the complex pathophysiology and heterogeneity NALFD, identification potential therapeutic targets is clinically important. Here, we demonstrated that TRIM56 protein abundance markedly downregulated livers individuals with mice...
Abstract Tumour necrosis factor receptor-associated 6 (TRAF6) is a ubiquitin E3 ligase that regulates important biological processes. However, the role of TRAF6 in cardiac hypertrophy remains unknown. Here, we show levels are increased human and murine hypertrophied hearts, which regulated by reactive oxygen species (ROS) production. Cardiac-specific Traf6 overexpression exacerbates response to pressure overload or angiotensin II (Ang II) challenge, whereas deficiency causes an alleviated...
Summary Cytoplasmic male sterility ( CMS ) has attracted great interest because of its application in crop breeding. Despite increasing knowledge , not much is understood about molecular mechanisms. Previously, orf H 79 was cloned and identified as the gene Honglian rice, but how ORFH protein causes pollen abortion still unknown. Through bacterial two‐hybrid library screening, P 61, a subunit mitochondrial electron transport chain ETC complex III selected candidate that interacts with 79....
NAFLD is the most prevalent chronic liver disease without any Food and Drug Administration-approved pharmacological intervention in clinic. Fatty acid synthase (FASN) one of attractive targets for treatment because its robust rate-limiting capacity to control hepatic de novo lipogenesis. However, regulatory mechanisms FASN potential therapeutic strategies targeting remain largely unknown.Through a systematic interactomics analysis FASN-complex proteins, we screened identified sorting nexin 8...
Global distributions and trends of the risk-attributable burdens chronic obstructive pulmonary disease (COPD) have rarely been systematically explored. To guide formulation targeted accurate strategies for management COPD, we analyzed COPD attributable to known risk factors.Using detailed data from Burden Disease study 2019, disability-adjusted life years (DALYs), lived with disability (YLDs), lost (YLLs), deaths each factor 1990 2019. Additionally, calculated estimated annual percentage...
Background: Pathological cardiac hypertrophy is one of the leading causes heart failure with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing protein 16) has been recognized as a pivotal regulator to control cell survival, immune response, and oxidativestress. However, role Trim16 in unknown. Methods: We generated cardiac-specific knockout mice adeno-associated virus serotype 9–Trim16 evaluate function pathological myocardial hypertrophy. direct effect on...
Emerging evidence suggests an association between remnant cholesterol (RC) and vascular damage hypertension. However, this has not been explored in a large-scale population China, temporal relationship RC hypertension also needs to be investigated.We conducted retrospective cross-sectional study 2,199,366 individuals longitudinal 24,252 with repeated measurements of lipid profile blood pressure at least 3-year follow-up. The logistic model was used explore the components analysis. Cox...
Tripartite motif 8 (TRIM8), an E3 ligase ubiquitously expressed in various cells, is closely involved innate immunity. However, its role nonalcoholic steatohepatitis largely unknown. Here, we report evidence that TRIM8 a robust enhancer of and complications induced by high‐fat diet or genetic deficiency ( ob/ob ). Using gain‐of‐function loss‐of‐function approaches, observed dramatic exacerbation insulin resistance, hepatic steatosis, inflammation, fibrosis hepatocyte‐specific overexpression,...
Stroke is one of the leading causes morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, excitotoxicity contribute to neuronal death during ischemic stroke; however, mechanisms underlying these complicated pathophysiological processes remain be fully elucidated. Here, we found that expression tumor necrosis factor receptor-associated 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in mice. TRAF6 ablation male mice decreased infarct volume...