A5100335539- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Cancer-related gene regulation
- Porphyrin and Phthalocyanine Chemistry
- Mitochondrial Function and Pathology
- Luminescence and Fluorescent Materials
- Nitric Oxide and Endothelin Effects
- Aquaculture disease management and microbiota
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Aquaculture Nutrition and Growth
- Cardiac Ischemia and Reperfusion
- Plant Molecular Biology Research
- Legionella and Acanthamoeba research
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- interferon and immune responses
Hainan Medical University
2024-2025
State Key Laboratory of Genetic Engineering
2023-2024
Fudan University Shanghai Cancer Center
2024
Center for High Pressure Science & Technology Advanced Research
2024
Southern Medical University
2024
First Hospital of China Medical University
2024
Zhujiang Hospital
2024
Fudan University
2023-2024
China Medical University
2024
Yangzhou University
2023-2024
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
Endothelin-1 is implicated in the pathogenesis of hypertension, but underlying mechanisms remained elusive. Our previous study found that inhibition mitochondrial fission smooth muscle cells suppressed phenylephrine- and high K+-induced artery constriction. Here, we studied effects inhibitors on endothelin-1-induced vasoconstriction.The tension rat mesenteric arteries thoracic aorta was measured by using a multi-wire myograph system. Mitochondrial morphology aortic observed transmission...
The receptors of Notch family play an important role in controlling the development, differentiation, and function multiple cell types. aim this study is to investigate Notch1 signaling upon immune suppression induced by melanoma cells.Melanoma line B16 cells were transfected lentivirus containing mouse gene or shRNA generate that highly lowly expressed Notch1. anti-tumor response was comprehensively appraised murine tumor model immunocompetent immunodeficient mice. ratios CD3+CD8+ cytotoxic...
Anemia commonly aggravates the severity of respiratory diseases, whereas thus far, few studies have elucidated impact anemia on coronavirus disease 2019 (COVID-19). The aim this study was to evaluate clinical characteristics patients with anemia, and further explore relationship between COVID-19. In single-center, retrospective, observational study, a total 222 confirmed admitted Wuhan Ninth Hospital from 1 December 20 March 2020 were recruited, including 79 143 without anemia. Clinical...
ABSTRACT Clostridium difficile can infect the large intestine and cause colitis when normal intestinal microbiota is altered by antibiotic administration. Little known about innate immune signaling pathways that marshal inflammatory responses to C. infection whether protective pathogenic be dissociated. Toll-like receptors predominantly signal via MyD88 adaptor protein are important mediators of in mucosa. Here, we demonstrate MyD88-mediated signals trigger neutrophil CCR2-dependent Ly6C hi...
Cancer progression is associated with alterations of intra- and extramedullary hematopoiesis to support a systemic tumor-promoting myeloid response. However, the functional specialty, mechanism, clinical relevance (EMH) remain unclear. Here, we showed that heightened splenic myelopoiesis in tumor-bearing hosts was not only characterized by accumulation precursors, but also profound early hematopoietic stem/progenitor cells (HSPCs). With distinct capability produce respond...
Clostridium difficile is a spore-forming bacterium that infects the lower intestinal tract of humans and most common known cause diarrhea among hospitalized patients. colitis mediated by toxins develops during or following antibiotic administration. We have used murine model C. infection, which reproduces major features human disease, to study effect innate immune activation on resistance infection. found administration purified Salmonella-derived flagellin, Toll-like receptor 5 (TLR5)...
Tree peony (Paeonia ostii) is an economically important ornamental plant native to China. It also notable for its seed oil, which abundant in unsaturated fatty acids such as α-linolenic acid (ALA). Here, we report chromosome-level genome assembly (12.28 Gb) of P. ostii. In contrast monocots with giant genomes, tree does not appear have undergone lineage-specific whole-genome duplication. Instead, explosive LTR expansion the intergenic regions within a short period (~ two million years) may...
The high incidence of recurrence and metastasis hepatocellular carcinoma (HCC) necessitate the discovery new predictive biomarkers invasion prognosis. Minichromosome maintenance complex component 6 (MCM6), which has been reported to up-regulate in multiple malignancies, was considered be a novel diagnoses biomarker HCC. However, its functional contributions prognostic value remain unclear.The expression MCM6 analyzed 70 HCC tissues 5 cell lines by immunohistochemistry real-time RT-PCR. roles...
BACKGROUNDDespite an increasing appreciation of the roles that myeloid cells play in tumor progression and therapy, challenges remain interpreting tumor-associated response balance its translational value. We aimed to construct a simple reliable signature for hepatocellular carcinoma (HCC).METHODSUsing situ immunohistochemistry, we assessed distribution major subtypes both peri- intratumoral regions HCC. A 2-feature-based, myeloid-specific prognostic signature, named score (MRS), was...
Recent studies have demonstrated that splenic extramedullary hematopoiesis (EMH) is an important mechanism for the accumulation of myeloid-derived suppressor cells (MDSCs) in tumor tissues, and thus contributes to disease progression. Icaritin, a prenylflavonoid derivative from plants Epimedium genus, has been implicated as novel immune-modulator could prolong survival hepatocellular carcinoma (HCC) patients. However, it unclear whether icaritin achieves its anti-tumor effects via regulation...
A 56-day feeding trial was conducted to investigate the effects of genistein on growth, lipid metabolism, antioxidant capacity, and immunity common carp fed with high-carbohydrate or high-fat diets. Five diets were used feed fish: control diet (5% fat; CO), (11% HF), (45% carbohydrate; HC), HF HC 500 mg/kg (FG CG). Results showed that final body weight (FW) specific growth rate (SGR) significantly reduced, but supplementation resulted in higher values FW SGR than group. Both high...
Abstract Hepatocellular carcinoma (HCC) with lung metastasis is associated poor prognosis and therapeutic outcomes. Studies have demonstrated that stiffened stroma can promote in various tumors. However, how the mechanical microenvironment favors circulating tumor cells remains unclear metastatic HCC. Here, we found expression of cell migration-inducing hyaluronan-binding protein (CEMIP) was closely pre-metastatic niche formation by increasing matrix stiffness. Furthermore, upregulated serum...
Abstract Propofol is one of the most extensively used intravenous anaesthetic agents, which has been found to improve surgical intervention outcome several types cancer, including hepatocellular carcinoma (HCC). Additionally, in vitro and vivo experiments have also indicated that propofol affects biological behaviour HCC. However, underlying mechanisms resection HCC with not fully understood. In present study, we aimed investigate mechanism inhibition growth invasion cells. Our results...
To examine if BODIPY-electron acceptor conjugates can generate excited triplet state and singlet oxygen efficiently via a photoinduced charge separation–charge recombination (CS-CR) mechanism, seven compounds of (A) type are synthesized, in which an x-nitro-phenyl (x = ortho, meta, para) or pyridyl subunit on the BODIPY meso-position acts as acceptor. The photophysical properties formation efficiency measured solvents different polarity. decrease with increase electron withdrawing ability...
Immune checkpoint inhibitor (ICI) shows low response rate in hepatocellular carcinoma (HCC) but the mechanisms underlying ICI resistance remains unclear. Interferon-γ (IFN-γ) has been widely determined as a prototypical antitumor cytokine. However, growing studies suggest that IFN-γ also mediates immunosuppression to promote tumor progression. Herein, we explored whether ICI-induced could activate immunosuppressive TGF-β1 mediate resistance. We demonstrated cholesterol biosynthetic enzyme,...
Abstract Hypertrophic scar development is a complication associated with wound healing, impacting local appearance and function. The type I/III collagen ratio affects the extent of hypertrophic scarring; reduced can ameliorate this. In this study, recombinant human III was developed. Liquid chromatography–tandem mass spectrometry used to determine its amino acid sequence confirm high level homology natural collagen. Recombinant displayed no cytotoxicity did not confer skin irritation...
Papillary thyroid carcinoma (PTC) is globally prevalent and associated with an increased risk of lymph node metastasis (LNM). The role cancer-associated fibroblasts (CAFs) in PTC remains unclear.
Abstract All of life encodes information with DNA. While tools for sequencing, synthesis, and editing genomic code have transformed biological research, intelligently composing new systems would also require a deep understanding the immense complexity encoded by genomes. We introduce Evo 2, foundation model trained on 9.3 trillion DNA base pairs from highly curated atlas spanning all domains life. train 2 7B 40B parameters to an unprecedented 1 million token context window single-nucleotide...