A5100449386- Protein Interaction Studies and Fluorescence Analysis
- Drug Transport and Resistance Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Surfactants and Colloidal Systems
- Protein purification and stability
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Antibiotics Pharmacokinetics and Efficacy
- Advanced biosensing and bioanalysis techniques
- Biological Activity of Diterpenoids and Biflavonoids
- Antifungal resistance and susceptibility
- Hedgehog Signaling Pathway Studies
- Cardiovascular Syncope and Autonomic Disorders
- Neonatal Health and Biochemistry
- Nail Diseases and Treatments
- Microbial Metabolites in Food Biotechnology
- Ginseng Biological Effects and Applications
- Forest Insect Ecology and Management
- Electrochemical sensors and biosensors
- Fungal Plant Pathogen Control
- Enzyme Structure and Function
- Nitrogen and Sulfur Effects on Brassica
- Oil Palm Production and Sustainability
Baotou Medical College
2025
Jiangxi University of Traditional Chinese Medicine
2023
Wuhan University
2022
Renmin Hospital of Wuhan University
2022
Sichuan University
2021
West China Hospital of Sichuan University
2021
Southern Medical University Shenzhen Hospital
2020-2021
Third Affiliated Hospital of Southern Medical University
2020-2021
Beijing Haidian Hospital
2021
Hubei University
2018
Endothelin-1 is implicated in the pathogenesis of hypertension, but underlying mechanisms remained elusive. Our previous study found that inhibition mitochondrial fission smooth muscle cells suppressed phenylephrine- and high K+-induced artery constriction. Here, we studied effects inhibitors on endothelin-1-induced vasoconstriction.The tension rat mesenteric arteries thoracic aorta was measured by using a multi-wire myograph system. Mitochondrial morphology aortic observed transmission...
As a light rare earth element, Sm and Sm2O3 are widely used in various fields such as electronics, chemistry, medicine. Their distribution the environment, accumulation biological organisms exposure through medicinal pathways have attracted increasing public attention. It is crucial to clarify impact of on human health. In this study, we applied 24 h post-fertilization (hpf) zebrafish embryos investigated toxic effects mechanisms Sm2O3. The results showed that induced developmental...
We explored potential biomarkers and molecular mechanisms regarding multiple benefits after bariatric surgery. Differentially expressed genes (DEGs) for subcutaneous adipose tissue (AT) surgery were identified by analyzing two expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI network, gene-microRNAs gene-TFs networks interrogated to identify hub associated pathways. Co-expressed DEGs included one that was up-regulated 22 down-regulated genes. The analyses...
Abstract Background Lung cancer is the leading cause of cancer-related mortality. The alteration DNA methylation plays a major role in development lung cancer. Methylation biomarkers become possible method for diagnosis. Results We identified eleven cancer-specific markers ( CDO1, GSHR, HOXA11, HOXB4-1, HOXB4-2, HOXB4-3, HOXB4-4, LHX9, MIR196A1 , PTGER4-1, and PTGER4-2 ), which could differentiate benign malignant pulmonary nodules. levels these are significantly higher tissues. In...
Candida albicans is the most common fungal pathogen in humans. The emergence of resistance to azole antifungals has raised issue using such combination optimise therapeutic outcome. objective this study was evaluate vitro synergy pseudolaric acid B (PAB) and fluconazole (FLC) against clinical isolates C. albicans. antifungal activity PAB, a diterpene from Pseudolarix kaempferi Gordon, evaluated alone with FLC 22 FLC-resistant (FLC-R) 12 FLC-susceptible (FLC-S) chequerboard microdilution...
Diabetic cardiovascular autonomic neuropathy (DCAN) seriously threatens the prognosis and quality of life patients with type 2 diabetes mellitus, associated increased mortality. The present study aimed to investigate relevant risk factors DCAN.The enrolled a total 109 mellitus. DCAN was defined as score at least points in Ewing tests. updated homeostasis model assessment insulin resistance (HOMA2-IR) based on fasting C-peptide calculated reflect resistance. Logistic regression analysis,...
Biodiesel produced from woody oil plants is considered a green substitute for fossil fuels. However, potential negative impact of growing on large scale the introduction highly invasive species into susceptible regions. In this study, we examined invasion risk in China's protected areas under future climate conditions. We simulated current and distributions three plants, Jatropha curcas, Ricinus communis, Aleurites moluccana, two change scenarios (RCP2.6 RCP8.5) up to 2050 using distribution...
Mutations in insulin receptor genes can cause severe resistance syndrome. Compared with Rabson-Mendenhall Syndrome and Donohue's Syndrome, type A syndrome is generally not serious. The main manifestations woman are hyperinsulinemia, resistance, acanthosis nigricans, hyperandrogenism, polycystic ovary. Case Presentation. 13-year-old girl (Han nationality) visited the hospital due to hairiness nigricans. Further examination revealed elevated blood glucose, Analysis of gene by sequencing showed...
Biofilm formation by Staphylococcus lugdunensis involves of an extracellular matrix; however, the identity constituents responsible for structure biofilms fabricated different clinical strains is largely unclear. Here, produced 24 isolates S. were characterized. The optimal medium was selected, and biofilm-forming capacity assessed. Extracelullar polymeric substances (EPS) contributing to biofilm robustness determined evaluating susceptibility EPS-degrading agents using field emission...
WK234, a novel bisindolymaleimide derivative, was designed as protein kinase Cβ (PKCβ) inhibitor. The objective of this study to evaluate the anti-tumor activity WK234 in human chronic myelogenous leukemia (CML) K562 cell line and investigate possible mechanisms its action. results show that inhibited proliferation time- dose-dependent manner. increased cytochrome C release caspase-3 cleavage, which indicates it induced apoptosis via mitochondria- caspase-mediated pathways. Western blotting...
Abstract In this study, a novel signal‐amplified strategy for sensitive electrochemical sandwiched immunoassay of carcinoembryonic antigen (CEA) was constructed based on aminofunctionalized graphene oxide (GO‐NH 2 ) supported AgNPs used as catalytic labels secondary anti‐CEA and β‐galactosidase (β‐Gal), Meanwhile, sulfhydrylation single‐wall carbon nanotubes (SWCNTs‐SH) substrate materials embellished gold electrode through Au‐SH connected with nanoparticles to form...
Ethnopharmacological relevance: Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine diseases observed among women age. Autophagic disorder, insulin resistance, oxidative stress, and inflammation have been considered to be key etiological components PCOS. Zishen Qingre Lishi Huayu Recipe (ZQLHR) a multi-component, multi-target Chinese medicine based on concept holistic treatment. It used nourish kidneys, clear heat, disperse blood stasis, remove dampness through...