A5064120872- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Neurogenetic and Muscular Disorders Research
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Crustacean biology and ecology
- T-cell and Retrovirus Studies
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Genetic factors in colorectal cancer
- Amyotrophic Lateral Sclerosis Research
- Ovarian cancer diagnosis and treatment
Peking University
2023-2025
Peking University Cancer Hospital
2023-2025
Inner Mongolia Medical University
2015-2025
Kaohsiung Municipal Hsiao-Kang Hospital
2025
First Affiliated Hospital of Xi'an Jiaotong University
2024
Sichuan University
2021-2024
West China Second University Hospital of Sichuan University
2021-2024
Affiliated Hospital of North Sichuan Medical College
2024
Shandong University of Traditional Chinese Medicine
2023
Berry Oncology (China)
2023
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This multicenter, randomized, open-label phase 3 trial aimed to further assess the efficacy and safety of camrelizumab followed by adjuvant compared alone. A total 391 patients with thoracic LA-ESCC (T1b-3N1-3M0 or T3N0M0) were stratified clinical stage (I/II, III IVA) randomized in 1:1:1...
Lipid metabolism reprogramming is a hallmark for tumor which contributes to tumorigenesis and progression, but the commonality difference of lipid among pan-cancer not fully investigated. Increasing evidences suggest that alterations in metabolism, including metabolite abundance accumulation metabolic products, lead local immunosuppression microenvironment. An integrated analysis cancers from different tissues using multiple omics data may provide novel insight into understanding...
Fibroblast-like synoviocytes (FLS) with aberrant expression of microRNA (miRNA) are critical pathogenic regulators in rheumatoid arthritis (RA).Previous studies have found that overexpression or silencing miRNA can contribute to the development miRNA-based therapeutics models.In this study, we explored effects miR-27a on cell migration and invasion cultured FLS from RA patients.We was markedly downregulated serum, synovial tissue, patients.Meanwhile, follistatin-like protein 1 (FSTL1)...
Tumor suppressor TP53 (or p53) is one of the most important regulators in numerous physiological and pathological processes. Recently, miRNA-mediated post-transcription regulation p53 has been studied. However, systematic studies miRNA targeting sites within gene are still a challenging task. Here, we developed dual-color assay capable identifying certain gene, specifically , simple, direct, robust manner. Results showed that was direct critical target miR-19b, but not miR-19a, regardless...
Diabetic nephropathy (DN) is regarded as the leading cause of end-stage renal disease worldwide and lacks novel therapeutic targets. To screen verify special biomarkers for glomerular injury in patients with DN, fifteen datasets were retrieved from Gene Expression Omnibus (GEO) database, correspondingly divided into training testing cohorts then merged. Using limma package, 140 differentially expressed genes (DEGs) screened out between 81 DN samples 41 normal ones cohort. With help...
Abstract Fibroblast activation protein ( FAP ) has been indicated to express in cancer‐associated fibroblasts (CAFs) most cancers. This work was dedicated exploring 's effects on hepatocellular carcinoma (HCC). The data were extracted from Cancer Genome Atlas, Gene Expression Omnibus, ImmPort, and Reactome databases. correlation between HCC patients' prognosis explored via survival analysis. qRT‐PCR western blot analysis used analyze the mRNA expression levels, respectively. cell...
Long noncoding RNA small nucleolar host gene 1 (lncRNA SNHG1) plays a crucial role in the occurrence and progression of various tumors. This study investigates function lncRNA SNHG1 hepatocellular carcinoma (HCC). We discovered that is significantly upregulated HCC markedly enhances cell proliferation, migration, invasion, while simultaneously suppressing apoptosis cells. Furthermore, was found to downregulate miR-7-5p expression. Overexpression counteracted suppression invasion caused by...
Abstract Cancer‐associated fibroblasts (CAFs) are a major cellular component in the tumor microenvironment and have been shown to exhibit protumorigenic effects hepatocellular carcinoma (HCC). This study aimed delve into mechanisms underlying tumor‐promoting of CAFs HCC. Small RNA sequencing was conducted screen differential expressed microRNAs exosomes derived from normal (NFs). The miR‐92a‐3p expression then measured using reverse transcriptase quantitative real‐time PCR CAFs, NFs,...
Abstract Background: Early diagnosis can significantly reduce colorectal cancer deaths. We sought to identify serum PIWI-interacting RNAs (piRNAs) that could serve as sensitive and specific noninvasive biomarkers for early detection. Methods: screened the piRNA expression profile in sera from 7 patients with normal controls using small RNA sequencing. Differentially expressed piRNAs were measured a training cohort of 140 reverse transcription quantitative PCR. The identified evaluated two...
Abstract Purpose Reducing radiation dose attributed to computed tomography (CT) may compromise the accuracy of organ segmentation, an important step in 177 Lu DOTATATE therapy that affects both activity and mass estimates. This study aimed facilitate CT reduction using deep learning methods for patients undergoing serial single photon emission (SPECT)/CT imaging during therapy. Methods The patient dataset hosted Deep Blue Data was used this study. noise insertion method incorporating effect...
Chaperone-mediated autophagy (CMA) is a specific form of that selectively targets proteins containing KFERQ-like motif and relies on the chaperone protein HSPA8/HSC70 for substrate recognition. In SERPINA1/a1-antitrypsin deficiency (AATD), disease characterized by hepatic buildup SERPINA1E342K/ATZ, CMA's role had been unclear. This work demonstrates critical CMA plays in preventing SERPINA1E342K/ATZ accumulation; suppressing worsens accumulation while activating it through chemical...
To investigate the inhibitory effect of astragaloside IV on pathological functions cancer-associated fibroblasts, and to explore underlying mechanism.Paired gastric normal fibroblast (GNF) (GCAF) cultures were established from resected tissues. GCAFs treated with vehicle control or different concentrations IV. Conditioned media prepared GNFs, GCAFs, control-treated IV-treated used culture BGC-823 human cancer cells. Proliferation, migration invasion capacities cells determined by MTT, wound...
The aim of this study was to evaluate the effectiveness and toxicities three-dimensional conformal radiation therapy (3DCRT), intensity-modulated (IMRT), volumetric-modulated arc (VMAT) in patients with cervical esophageal cancer. Specifically, we asked whether technological advances conferred an advantage respect clinical curative effect. Seventy-eight cancer treated definitive radiotherapy or without concomitant chemotherapy at our institution between 2007 2014 were enrolled study: 26...
Ovarian Clear Cell Carcinoma (OCCC) displays distinctive clinical and molecular characteristics confers the worst prognosis among all ovarian carcinoma histotypes when diagnosed at advanced stage because of lack effective therapy. IGF2BP3 is an RNA binding protein that modulates gene expression by posttranscriptional action. In this study, we investigated roles in progression OCCC. We used 328 OCCCs from AOVT (the Alberta Tumor Type study) COEUR Canadian Experimental Unified Resource)...
Abstract Background Lung cancer is the leading cause of cancer-related mortality. The alteration DNA methylation plays a major role in development lung cancer. Methylation biomarkers become possible method for diagnosis. Results We identified eleven cancer-specific markers ( CDO1, GSHR, HOXA11, HOXB4-1, HOXB4-2, HOXB4-3, HOXB4-4, LHX9, MIR196A1 , PTGER4-1, and PTGER4-2 ), which could differentiate benign malignant pulmonary nodules. levels these are significantly higher tissues. In...
Cervical cancer is one of the most common gynecological cancers. Cisplatin resistance remains a major hurdle in successful treatment cervical cancer. Aberrant expression long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are implicated cisplatin resistance. However, regulatory functions lncRNAs miRNAs underlying mechanisms still elusive. Our qRT-PCR assays verified that miR-206 levels were down-regulated cisplatin-resistant cells. The introduction sensitized cells to cisplatin. luciferase...
Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) involved colorectal (CRC) progression. The present study aimed to examine the functional role of HOTAIR conferring radiotherapy CRC cells, as well underlying mechanism. relative expression levels were examined 70 pairs tumor para-cancerous tissues, radiosensitive radioresistant samples. correlations...
Molecular targeting is a powerful approach for aggressive claudin-low breast cancer (CLBC). Overexpression of PI3K catalytic subunit gamma (PIK3CG) in human CLBC offering promising opportunity targeted therapies. We utilized specific inhibitor PIK3CG combined with paclitaxel (PTX) to treat cells vitro and vivo.The tumor growth apoptosis were analyzed by CCK8, plate clone formation assay, tumorsphere Hoechst staining flow cytometry. The invasion metastasis ability investigated wound healing...
The acquisition of cancer stem-like properties is believed to be responsible for metastasis and therapeutic resistance in cervical (CC). CC tissues display a high expression level hexokinase 2 (HK2), which critical the proliferation migration cells. However, little known about functional role HK2 maintenance stem cell-like ability cisplatin Here, we showed that significantly elevated tissues, correlates with poor prognosis. overexpression (or knockdown) can promote inhibit) sphere-forming In...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. In past decades, HCC treatment has achieved great progress; however, overall prognosis remains poor. Therefore, it need hour to identify new prognostic biomarkers which can advance our understanding related underlying molecular mechanism adverse and apply them clinical work in prediction. present study, data 576 patients 292 normal control cases from TCGA ICGC databases were enrolled bioinformatic...
The Pacific white shrimp Litopenaeus vannamei is an economically important penaeid species worldwide. Under farming conditions, the full ovarian maturation of L. generally depends on combination artificial ablation unilateral eyestalk and feeding high-quality natural diets, suggesting that nutrient accumulation to maturation. In this study, we aimed investigate gene expression related nutritional in during development by transcriptomic analysis. A total 52.45 Gb transcriptome data were...