A5101997425- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Chromosomal and Genetic Variations
- Extracellular vesicles in disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac electrophysiology and arrhythmias
- Adipokines, Inflammation, and Metabolic Diseases
- Sepsis Diagnosis and Treatment
- Tannin, Tannase and Anticancer Activities
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- Heart Rate Variability and Autonomic Control
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- RNA Interference and Gene Delivery
First Affiliated Hospital of Xinjiang Medical University
2023-2025
Xinjiang Medical University
2023-2025
Peking University
2024
Inner Mongolia Medical University
2017-2024
Peking University Cancer Hospital
2024
Nanjing University of Chinese Medicine
2019
Abstract Background: Early diagnosis can significantly reduce colorectal cancer deaths. We sought to identify serum PIWI-interacting RNAs (piRNAs) that could serve as sensitive and specific noninvasive biomarkers for early detection. Methods: screened the piRNA expression profile in sera from 7 patients with normal controls using small RNA sequencing. Differentially expressed piRNAs were measured a training cohort of 140 reverse transcription quantitative PCR. The identified evaluated two...
To investigate the inhibitory effect of astragaloside IV on pathological functions cancer-associated fibroblasts, and to explore underlying mechanism.Paired gastric normal fibroblast (GNF) (GCAF) cultures were established from resected tissues. GCAFs treated with vehicle control or different concentrations IV. Conditioned media prepared GNFs, GCAFs, control-treated IV-treated used culture BGC-823 human cancer cells. Proliferation, migration invasion capacities cells determined by MTT, wound...
The common occurrence of atrial fibrillation (AF) as a cardiac arrhythmia, along with its link to sleep deprivation (SD), is gaining more acknowledgment. Even progress in comprehending the development AF, molecular connections between SD and AF are still not well-defined. objective this research was pinpoint shared routes responsible for SD-induced investigate possible treatment targets. Utilizing bioinformatics, we examined two transcriptome datasets from Gene Expression Omnibus (GEO)...
Melanoma is the major lethal skin malignancy. However, critical molecular drivers governing melanoma progression and prognosis are still not clear. By analyzing The Cancer Genome Atlas (TCGA) data, we identified FUT8-AS1 as a prognosis-related long non-coding RNA (lncRNA) in melanoma. We further confirmed that downregulated Reduced expression of correlated with aggressive clinical factors inferior overall survival. Using vitro functional assays, our findings demonstrated ectopic represses...
Objective Although urinary extracellular vesicles (uEVs) have been extensively studied in various cancers, their involvement breast cancer (BC) remains largely unexplored. The non-invasive nature of urine as a biofluid and its abundant protein content offer considerable potential for the early detection cancer. Methods This study analyzed proteomic profiles uEVs from BC patients healthy controls (HC). dysregulation ECM1 ANXA1 was validated larger cohort 128 patients, 25 HC benign nodules...
This study aimed to identify a newly identified target involved in atrial fibrillation (AF) linked chronic obstructive sleep apnea (COSA) through an integrative analysis of transcriptome and proteome.Fifteen beagle canines were randomly assigned three groups: control (CON), (OSA), OSA with superior left ganglionated plexi ablation (OSA+GP). A COSA model was established by intermittently obstructing the endotracheal cannula during exhalation for 12 weeks. Left parasternal thoracotomy fourth...
Although the effect of lysosome-associated protein transmembrane 4 beta (LAPTM4B) on proliferation, migration, and invasion breast cancer (BC) cells has already been studied, its specific role in BC progression is still elusive. Here, we evaluated different levels LAPTM4B expression invasion, adhesion, tumor formation abilities vitro, as well vivo.We investigated influence MCF-7 cell tube vitro through overexpression or knockdown vivo.Cell growth curves colony assays showed that promoted...
Abstract Transmembrane protein 98 (TMEM98) is a recently discovered gene, the inhibition of which has preliminarily been demonstrated to inhibit progression several solid cancers in vitro. However, its involvement tumorigenesis gastric cancer (GC) not reported. Here, we aimed explore expression TMEM98 GC tissues and cell lines determine role proliferation invasion. was significantly upregulated tissues, associated with low survival rate patients. Interestingly, invasion were promoted by...
New-onset atrial fibrillation (AF) in sepsis significantly impacted patient morbidity and mortality, yet the optimal animal model for studying this condition remains undetermined. This study aimed to establish a stable new-onset AF explore molecular mechanisms involved. Forty-seven Sprague-Dawley rats were utilized, with cecal ligation puncture (CLP) group divided into 0.6 mm 1.0 needle outer diameter subgroups, lipopolysaccharide (LPS) 5 mg/kg, 10 15 20 mg/kg dosage subgroups. The incidence...
Abstract Objective This study aimed to investigate the influence of Xanthii fructus on expression small noncoding RNA (sncRNA) and malignant behaviors lung cancer cells. Method A549 cells were treated with extract. SncRNA was detected by real-time PCR. Proliferation, anchorage-independent growth, invasion capacities determined using Cell Counting Kit (CCK)-8, soft agar colony formation, Matrigel assays, respectively. Results extract downregulated microRNA (miR)-21 upregulated...
Objective: Adipose tissue may play a role in the pathophysiology of patients with heart failure normal left ventricular ejection fraction (LVEF). Recent studies have shown that (LV) global longitudinal strain (GLS) can detect subclinical LV systolic dysfunction individuals LVEF, and such strongly predicts future cardiovascular events. We therefore investigated visceral fat subcutaneous would be associated, independently body mass index, GLS cardiac structure Chinese subjects LVEF. Design...