A5053134229- RNA modifications and cancer
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Inflammation biomarkers and pathways
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- HER2/EGFR in Cancer Research
- S100 Proteins and Annexins
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- RNA Research and Splicing
- Breast Cancer Treatment Studies
- Ultrasound and Hyperthermia Applications
- Adrenal and Paraganglionic Tumors
- Cancer-related cognitive impairment studies
Kerala Veterinary and Animal Sciences University
2025
Northeast Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Xuzhou Medical College
2019-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2023-2024
The University of Texas Southwestern Medical Center
2024
Sun Yat-sen University
2023-2024
Harbin Medical University
2018-2020
Second Affiliated Hospital of Harbin Medical University
2018-2020
Third Affiliated Hospital of Harbin Medical University
2018-2020
ObjectivesPatients with epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma (LUAD) can benefit from individualized targeted therapy. This study aims to develop, compare, analyse prediction models based on dual-energy spectral computed tomography (DESCT) and CT-based radiomic features non-invasively predict EGFR mutation status LUAD.Materials methodsPatients LUAD (n = 175), including 111 patients 64 without mutations, were enrolled the current study. All randomly divided...
Abstract Background: Early diagnosis can significantly reduce colorectal cancer deaths. We sought to identify serum PIWI-interacting RNAs (piRNAs) that could serve as sensitive and specific noninvasive biomarkers for early detection. Methods: screened the piRNA expression profile in sera from 7 patients with normal controls using small RNA sequencing. Differentially expressed piRNAs were measured a training cohort of 140 reverse transcription quantitative PCR. The identified evaluated two...
Thymol (THY) is a phenolic monoterpene compound that has garnered attention due to its various biological properties, including antioxidant, anti-inflammatory, and immune-regulatory effects. The purpose of this study was determine the therapeutic protective effects THY in colitic mice, with particular focus on mechanisms involving gut microbiota. results showed early intervention (40 80 mg/kg) not only alleviated clinical symptoms colonic damage mice dextran sodium sulfate (DSS)-induced...
The purpose of this study was to evaluate the value quantitative shear wave elastography (SWE) in indicating axillary lymph node metastasis (LNM) invasive breast cancers (IBCs) and investigate if S100A4 plays a key role promoting increasing stiffness IBC.The differences SWE 223 IBC patients were compared between LNM+ LNM- groups optimal cutoff values for diagnosing LNM calculated. We searched gene expression omnibus (GEO) determine whether more highly expressed IBCs that than those LNM-....
Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target mRNA regulate gene posttranscriptional expression, and RBP-mediated RNA modification can the expression function of proto-oncogenes tumor suppressor genes. We systematically analyzed RBPs in pancreatic adenocarcinoma (PAAD) constructed an RBP-associated prognostic risk model. Methods: Gene data normal samples as well PAAD downloaded from TCGA-PAAD GTEx databases. Wilcoxon test univariate Cox analysis...
Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin ( cis -diamminedichloroplatinum (II); CDDP) and related drugs are main treatment option for CC; however, their efficacy is limited by development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological pathological cellular processes, including resistance cells. In this review, we describe some ncRNAs, miRNAs, lncRNAs...
BACKGROUND:T-box transcription factor protein 21 (TBX21) is expressed in immune cells and some tumor cells. Defects TBX21 gene can cause Th1/Th2 imbalance, which closely related to tumorigenesis. The expression clinical value of skin cutaneous melanoma (SKCM) are not clear. MATERIAL AND METHODS:RNA-Seq information were downloaded from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Wilcoxon signed-rank test logistic regression used explore the relationship between...
Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in world, with a low early diagnosis rate and high mortality. Integrin beta 5 (ITGB5) demonstrated to be potent tumor promoter several carcinomas. However, it unknown whether ITGB5 participates occurrence development PAAD. In this study, we confirmed expression PAAD its role promoting invasiveness transitivity Besides, knockdown increased cell sensitivity radiation by DNA damage repair MEK/ERK signaling...
Combining DNA damage repair inhibitors and chemotherapeutic agents is an emerging strategy in cancer treatment. In this study, we engineered the polycation nanoparticle (NP), which co-encapsulated inhibitor Dbait drug Docetaxel (Dtxl), using H1 nanopolymer (folate–-polyethylenimine600–cyclodextrin), size of H1/Dbait/Dtxl was about 117 nm. We demonstrated that enhanced efficiency radio-chemotherapy prostate cells by CCK-8 assay colony-forming assay. Importantly, improvement also validated...
Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) has been reported to play an essential role in the development and progression of various human cancers. However, its expression pattern possible mechanism hepatocellular carcinoma (HCC) remain be elucidated. In this study, we used western blot immunohistochemical staining detect protein expression. The effects ANP32A on proliferation, migration invasion HCC cells were examined using 5-ethynyl-20-deoxyuridine (EdU), colony formation,...
Abstract Background Radioresistance and immune escape are crucial reasons for unsatisfactory therapeutic effects of glioblastoma (GBM). Although triggering receptor expressed on myeloid cells-2 (TREM2) involved in forming immunosuppressive microenvironment, but the underlying mechanism its roles mediating cancer radioresistance remain unclear, moreover, efficient delivery drugs targeting TREM2 to GBM encounters serious challenges. Hence, this study aimed elucidate effect mechanisms targeted...
The present study aimed to reveal the function and underlying molecular mechanism of circRNA NIMA related kinase 6 (circNEK6) in promoting progression pancreatic ductal adenocarcinoma (PDAC).The differentially expressed circRNAs three paired PDAC tissues adjacent were identified by RNA sequencing. CircNEK6 was screened out further explore its relationship with prognosis patients. target microRNAs mRNAs circNEK6 analyzed through online databases detected quantitative real-time polymerase...
To analyze the ultrasonographic findings of invasive lobular carcinoma (ILC) breast in 360 women and correlations between characteristics intrinsic subtypes. We evaluated imaging according to lexicon American College Radiology Breast Imaging Reporting Data System (BI-RADS). The included features were shape, orientation, margin, echo pattern, posterior features, calcifications, vascularity masses presence architectural distortions. associations those ILC subtypes investigated. most common...
Objective Based on the ultrasonic characteristics of breast mass and axillary lymph nodes as well clinicopathological information, a model was developed for predicting node metastasis in cT1 cancer, relevant features associated with were identified. Methods Our retrospective study included 808 patients invasive cancer treated at Second Affiliated Hospital Cancer Harbin Medical University from February 2012 to August 2021 (250 cases positive group 558 negative group). We allocated 564...
Imaging-guided photodynamic therapy (PDT) has emerged as a promising protocol for cancer theragnostic. However, facile preparation of such theranostic system simultaneously achieving tumor location, real-time monitoring, and high-performance reactive oxygen species generation is highly desirable but remains challenging. Herein, we developed reasonable tumor-targeting strategy based on carbon dots (CDs)-decorated MnO2 nanosheets (HA-MnO2–CDs) with an active magnetic resonance...