The emergence of multidrug-resistant (MDR) pathogens, coupled with the limited effectiveness existing antibiotics in eradicating biofilms, presents a significant threat to global health care. This critical situation underscores urgent need for discovery and development antimicrobial agents. Recently, peptide-derived nanomaterials have shown promise combating such infections. Amino acid noncovalent forces, notably π–π stacking electrostatic interactions, remain underutilized guiding...

Intracellular bacterial infections and antimicrobial resistance are threatening global public health systems. Antimicrobial peptides a potential solution to combat resistance, but the design of self-assembled nanopeptides with dual functions cell penetration antibacterial properties intracellular bacteria remains challenge. Here, we propose strategy develop through chimerization core, hydrophobic motif, cell-permeable unit. The optimal nanopeptides, F3FT N3FT, exhibited potent activity...

Intensive breeding of broilers met the increasing demands human for broiler products, but it raised their increased susceptibility to various stressors resulting in disorder lipid metabolism. Pterostilbene, methoxylated analogue resveratrol, exhibits astonishing functions antioxidant, anti-inflammatory and glycolipid regulatory. The study aimed elucidate protective effects pterostilbene on liver explore potential mechanisms. A total 480 one-day-old male Arbor Acres (AA) were randomly divided...

In this paper, we consider the problem of tracking human motion with a 22-DOF kinematic model from depth images. contrast to existing approaches, our system naturally scales multiple sensors. The motivation behind approach, termed Multiple Depth Camera Approach (MDCA), is that by using several cameras, can significantly improve quality and reduce ambiguities as for example caused occlusions. By fusing images all available cameras into one joint point cloud, seamlessly incorporate information...

Commensalism coinfection of pathogens has seriously jeopardized human health. Currently, Kunitzin-RE, as an amphibian-derived bioactivity peptide, is regarded a potential antimicrobial candidate. However, its properties were unsatisfactory. In this study, set shortened variants Kunitzin-RE was developed by the interception peptide fragment and single-site mutation to investigate effect chain length, positive charge, hydrophobicity, amphipathicity, secondary structure on properties. Among...

In this paper, we study time-triggered distributed systems where periodic application tasks are mapped onto different end stations (processing units) communicating over a switched Ethernet network. We address the problem of level (i.e., both task- and network-level) schedule synthesis optimization. context, most recent works [10], [11] either focus on communication or consider simplified task model. work, formulate co-synthesis schedules as Mixed Integer Programming (MIP) model taking into...

The objective of the present study was to investigate effect vitamin E on laying performance, egg quality, fatty acid composition, antioxidant capacity, and several biochemical parameters hens fed corn distillers dried grains with solubles (DDGS) during period (40 63 wk age). A total 360 Hy-Line Variety Brown were randomly assigned 6 groups, consisting replicates 10 each. Hens allocated diets 1 through in a 3 × 2 factorial design. dietary treatments included levels DDGS (0, 10, 20%) (0 200...

Abstract Dissolved organic matter (DOM) in highly productive intertidal mangroves is an important carbon and nutrient source to the coastal ocean. In dynamic mangrove systems, both tidal pumping or geochemical factors can control DOM characteristics. The influence of groundwater flow on properties fluxes remains poorly understood. Here, we compared concentrations, sources, spectroscopic characteristics across a recharge‐discharge gradient. We used three‐dimensional array sampling strategy...

Recently, research on control and architecture co- design has been drawing increasingly more attention. This is because these techniques integrate the of controllers explore characteristics both sides to achieve efficient embedded systems. However, there still exist several challenges like large space inadequate trade-off opportunities for different objectives performance resource utilization. In this paper, we propose a co-optimization approach FlexRay-based distributed systems, that...

Recent advances in battery and drone technologies have opened up possibilities of commercial use drones. Private companies are looking into the using drones for deliveries from legal, technical, economical perspective. Nevertheless, management perspective such businesses has not yet been thoroughly investigated. In this paper, we identify that application a major impact costs, formulate an optimization problem to reduce aging batteries. We two sub-problems, assignment, scheduling derive...

Tryptophan has drawn wide attention due to its involvement in improving intestinal immune defense directly and indirectly by regulating metabolic pathways. The study aims elucidate the potential modulating roles of tryptophan protect against inflammation underlying molecular mechanisms. protective effects are examined lipopolysaccharide (LPS)-induced inflammatory model. We first found that markedly (p < 0.01) inhibited proinflammatory cytokines production nuclear factor κB (NF-κB) pathway...

Antimicrobial peptides (AMPs) have attracted attention in the field of food preservatives due to their favorable biosafety and potential antimicrobial activity. However, high synthetic cost, systemic toxicity, a narrow spectrum, poor activity become main bottlenecks for practical applications. To address these questions, set derived nonapeptides were designed based on previously discovered ultra-short peptide sequence template (RXRXRXRXL-NH2) screened identify an optimal peptide-based...

The development of automotive electronics and software systems is often associated with high costs due to their multi-domain nature (including control engineering, electronics, hydraulics, mechanics, etc). involvement these different disciplines makes it difficult for engineers test controllers them being integrated in the whole system, early phases. By introducing "XiL approach", ETAS wants leverage virtualization techniques order bring embedded desk every developer. XiL approach implies...