A5062023494- Cancer-related Molecular Pathways
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Carbohydrate Chemistry and Synthesis
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Lysosomal Storage Disorders Research
- Acute Myocardial Infarction Research
- Cell death mechanisms and regulation
- Ultrasound Imaging and Elastography
- S100 Proteins and Annexins
- ATP Synthase and ATPases Research
- Ultrasound and Hyperthermia Applications
- Neurosurgical Procedures and Complications
- Viral Infections and Vectors
- Traditional Chinese Medicine Analysis
- Mechanisms of cancer metastasis
- Nasal Surgery and Airway Studies
- Cerebrospinal fluid and hydrocephalus
- Reconstructive Facial Surgery Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
Metrum Research Group (United States)
2024-2025
Capital Medical University
2021-2025
First Affiliated Hospital of Bengbu Medical College
2025
Beijing Jishuitan Hospital
2025
Peking University
2025
Beijing Obstetrics and Gynecology Hospital
2021-2024
Air Force Medical University
2024
Chengdu University of Traditional Chinese Medicine
2024
Chengdu University
2023
Second Affiliated Hospital of Harbin Medical University
2018-2020
Resistance to anoikis and Epithelial-mesenchymal transition (EMT) are two processes critically involved in cancer metastasis. In this study, we demonstrated that after anchorage deprival, hepatocellular carcinoma (HCC) cells not only resisted anoikis, but also exhibited EMT process. Microarray expression profiling revealed of miR-424-5p was significantly decreased anoikis-resistant HCC cells. Ectopic overexpression sufficient reverse resistance block process inhibit malignant behaviors...
This study thoroughly assesses the factors affecting posttraumatic stress disorder (PTSD) in patients with breast cancers from a multidimensional perspective according to theory of unpleasant symptoms (TOUS). Additionally, it develops nomogram prediction model tailored for this group. A cross-section analysis involving seven major hospitals northern Anhui Province was performed collect data 1135 cancer survivors. The self-reported Posttraumatic Stress Disorder Checklist-Civilian Version...
// Jia Kang 1 , Stephen Jun Fei Chong Vignette Zi Qi Ooi Shireen Vali 2 Ansu Kumar 3 Shweta Kapoor Taher Abbasi Jayshree L. Hirpara 4 Thomas Loh 5 Boon Cher Goh and Shazib Pervaiz 1,6,7,8 Department of Physiology, Yong Loo Lin School Medicine, National University Singapore, Singapore Cellworks Group Inc., San Jose, CA, USA Research India Private Limited, Bangalore, Experimental Therapeutics Program, Cancer Science Institute, Otolaryngology, Healthcare System, 6 NUS Graduate for Integrative...
The purpose of this study was to evaluate the value quantitative shear wave elastography (SWE) in indicating axillary lymph node metastasis (LNM) invasive breast cancers (IBCs) and investigate if S100A4 plays a key role promoting increasing stiffness IBC.The differences SWE 223 IBC patients were compared between LNM+ LNM- groups optimal cutoff values for diagnosing LNM calculated. We searched gene expression omnibus (GEO) determine whether more highly expressed IBCs that than those LNM-....
Approximately 30% of rheumatoid arthritis patients achieve inadequate response to anti-TNF biologics. Attempts identify molecular biomarkers predicting have met with mixed success. This may be attributable, in part, the variable and subjective disease assessment endpoints large placebo effects typically used classify patient response. Sixty-one active RA despite methotrexate treatment, MRI-documented synovitis, were randomized receive infliximab or placebo. Blood was collected at baseline...
Abstract Objectives Reconstruction of large lower lip defects remains challenging in terms aesthetics, function and safety. The aim this study is to explore a modified nasolabial flap repair defects. Methods full‐thickness facial artery was used for reconstruction squamous cell carcinoma (LSCC) patients after tumor ablation. postoperative recovery obtained through clinical review follow‐up the first sixth month. Results There were four LSCC who received ablation at Beijing Stomatological...
The objectives of this study were to estimate the prognostic value tumour-stroma ratio (TSR) and tumour budding (TB) in oral tongue squamous cell carcinoma (OTSCC) establish a reliable model predict outcome OTSCC patients.A total 103 patients surgically treated at our hospital enrolled study. Chi-square tests, Kaplan-Meier analyses Cox proportional hazards regression models performed for statistical analysis.Fifty-six categorized as stroma-rich, 47 stroma-poor. Only pathological grade was...
To investigate the influence of preoperative statin therapy on rate major adverse cardiac and cerebrovascular events (MACCE) during hospital stay after successful percutaneous coronary intervention (PCI).Review patients who underwent PCI between June 2003 September 2005 (n = 3893) at Beijing Anzhen Hospital Capital University Medical Science. (Group I, statins, n 3361; group II, not 532). if was independently associated with reduction in risk postoperative outcomes PCI. Prognostic factors...
MicroRNAs (miRNAs) are small endogenous ssRNAs that regulate target gene expression post-transcriptionally through the RNAi pathway. A critical pre-processing procedure for detecting differentially expressed miRNAs is normalization, aiming at removing between-array systematic bias. Most normalization methods adopted miRNA data same used to normalize mRNA data; but very different from mainly because of possibly larger proportion probes, and much percentage left-censored probes below detection...
Abstract Background Diabetic foot is one of the most serious complications type 2 diabetes mellitus (T2DM), and its incidence increasing in China. Early detection abnormal microcirculation very important for prevention treatment diabetic foot. Objective To investigate value contrast-enhanced ultrasound (CEUS) diagnosing microcirculatory alterations dorsum patients with (T2DM). Methods Eighty-eight T2DM were included, among them 30 sustained without (group A), 28 lesions (no acute infection)...
Enzyme replacement therapy (ERT) is the only approved disease-modifying treatment modality for Pompe disease, a rare, inherited metabolic disorder caused by deficiency in acid α -glucosidase (GAA) enzyme that catabolizes lysosomal glycogen. First-generation recombinant human GAA (rhGAA) ERT (alglucosidase alfa) can slow progressive muscle degeneration characteristic of disease. Still, most patients experience diminished efficacy over time, possibly because poor uptake into target tissues....
Abstract Eosinophils differentiate in the bone marrow prior to migration vascular periphery and eventual residency tissues. While they can either be a harmful or helpful component of immune system, help aid allergic response as well modulate inflammation. Detection eosinophils blood samples was typically performed using H&E staining methods, however flow cytometric analysis whole allows researchers identify multiple cell types single sample that couldn’t done before. Here, we were able...
The effective surgical treatments of localized prostate cancer patients were explored. 90 admitted to our hospital selected as study subjects. They divided into research (treated by modified extraperitoneal total intrafascial laparoscopic radical prostatectomy) and control groups random number table method, having 45 cases each. operation time, bleeding volume, drainage hospitalization vascular endothelial stimulation index, urinary function, erectile complications, recurrence monitored...
Patients with non-muscle-invasive bladder cancer (NMIBC) who are at high and very risk of disease progression recommended for radical cystectomy (RC). However, the impact neoadjuvant chemotherapy (NAC) on survival outcomes in NMIBC patients undergoing RC remains unclear. diagnosed T1 high-grade underwent were identified from Surveillance, Epidemiology, End Results (SEER) database. Overall (OS) was assessed using Kaplan-Meier technique, multivariable Cox regression analysis conducted to...
Abstract The small GTPase Rac1 is involved in the activation of reduced NAD phosphate oxidase complex resulting superoxide production. We recently showed that Bcl-2 overexpression inhibited apoptosis by creating a pro-oxidant intracellular milieu, and inhibiting production sensitized Bcl-2-overexpressing cells to apoptotic stimuli. Gene silencing functional inhibition blocked Bcl-2-mediated increase levels tumor cells. provide evidence for co-localization physical interaction between 2...
Abstract Overexpression of Bcl-2 presents a major therapeutic challenge in the management hematopoietic and other malignancies. By conventional dogma blocks drug-induced apoptosis by inhibiting mitochondrial permeabilization downstream death amplification. Recently we demonstrated novel mechanism inhibition via inducing an increase oxygen consumption superoxide production. Interestingly, transfection cells with dominant negative mutant Rac1 or its knockdown sensitized expressing to...