A5100701681- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- Melanoma and MAPK Pathways
- Facial Rejuvenation and Surgery Techniques
- Cancer, Lipids, and Metabolism
- Infective Endocarditis Diagnosis and Management
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- Facial Nerve Paralysis Treatment and Research
- Burn Injury Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Planarian Biology and Electrostimulation
- Hair Growth and Disorders
- Antimicrobial Resistance in Staphylococcus
- S100 Proteins and Annexins
- Wound Healing and Treatments
- Bacterial Identification and Susceptibility Testing
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
National Taiwan University Hospital
2020
Fourth Hospital of Inner Mongolia
2017-2018
Sichuan University
2015
West China Hospital of Sichuan University
2015
Hubei University of Medicine
2014
Taihe Hospital
2014
Abstract We aimed to detect the effects of miR‐145‐5p on cell proliferation, apoptosis, migration, and invasion in NRAS ‐mutant, BRAF wild‐type melanoma cells, order figure out potential mechanisms provide a novel therapeutic target melanoma. RT ‐ qPCR western blot were used expression tumor tissues respectively. Luciferase assay was performed determine whether directly targeted . After transfecting mimics, inhibitors, cDNA siRNA into CHL‐1, VMM917 SK‐mel‐28 functional assays including MTT,...
Rapid and accurate identification of pathogens their antibiotic resistance directly from flagged blood cultures can aid clinicians in optimizing early treatment improve the clinical outcomes, especially settings associated with high rates bloodstream infection caused by vancomycin-resistant Enterococci (VRE) carbapenem-resistant Enterobacteriaceae (CRE). We compared results BioFire FilmArray Blood Culture Identification (BCID) panel those conventional methods for identifying susceptibility...
Accumulating evidences indicated that plasmacytoma variant translocation 1 (PVT1) plays vital roles in several cancers. However, the expression, functions, and clinical values of PVT1 melanoma are still unknown. In this study we measured expression tissues serum samples explored diagnostic value for effects on cell proliferation, cycle, migration. Our results, combined with publicly available data, revealed is upregulated compared nonneoplastic nevi tissues. Serum level significantly...
Melanoma is the most malignant skin cancer, which account for of skin-cancer-related deaths. Long noncoding RNA (lncRNA) a class RNAs with crucial roles in many cancers. However, lncRNAs melanoma have not been well studied. In present study, using public available data and clinical tissues samples, we found that lncRNA ILF3-AS1 up-regulated cell lines, correlated poor prognosis patients. Functional experiments showed knockdown inhibits proliferation, migration, invasion. Mechanistically,...
Melanoma is the major lethal skin malignancy. However, critical molecular drivers governing melanoma progression and prognosis are still not clear. By analyzing The Cancer Genome Atlas (TCGA) data, we identified FUT8-AS1 as a prognosis-related long non-coding RNA (lncRNA) in melanoma. We further confirmed that downregulated Reduced expression of correlated with aggressive clinical factors inferior overall survival. Using vitro functional assays, our findings demonstrated ectopic represses...
Purpose: In our previous study, we identified that lncRNA ILF3 antisense RNA 1 (ILF3-AS1) is increased and has oncogenic roles in melanoma. However, the cause of upregulation ILF3-AS1 modulation between melanoma are still unknown. This study aimed to investigate significances interaction Materials methods: The expression tissues cell lines was measured by quantitative real-time PCR (qRT-PCR). interactions were explored immunoprecipitation assay, transcription inhibition qRT-PCR, chromatin...
BACKGROUND:Our research purpose was to compare the curative efficacy of different skin grafting methods for treating third-degree burn wounds. MATERIAL AND METHODS:A total 105 patients with burns were involved in this study. The wounds these treated using three methods: Meek grafting, Stamp and Microskin grafting. Patients placed groups. graft survival rate, fusion time, wound healing time surgery, 1% body surface area (TBSA) treatment costs each group evaluated during after procedures....
Complications caused by autologous fat filling have been reported. Comprehensive knowledge of the possible adverse effects is needed.To determine association with ophthalmic function complications.Four adult New Zealand white rabbits were killed for a facial anatomy study. Sixty-four underwent harvest using Coleman technique. Autologous was minced or digested collagenase 1 and centrifuged to separate lipid granules. Either 0.2 mL 0.4 fat, granules, lipid, saline (control) retrogradely...
Melanoma is a common lethal skin cancer. Dissecting molecular mechanisms driving the malignancy of melanoma may uncover potential therapeutic targets. We previously identified miR-145-5p as an important tumor-suppressive microRNA in melanoma. Here, we further investigated roles long non-coding RNAs (lncRNAs) RP11-705C15.3, regulator miR-145-5p, oncogenic lncRNA RP11-705C15.3 competitively bound relieved repressive on its target NRAS, upregulated NRAS expression, and activated MAPK signaling....