A5030513777- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Cardiac Valve Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Pluripotent Stem Cells Research
- Pharmacological Effects of Natural Compounds
- Fungal Infections and Studies
- Aortic Disease and Treatment Approaches
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- Infective Endocarditis Diagnosis and Management
- RNA modifications and cancer
- Traumatic Brain Injury Research
- Antifungal resistance and susceptibility
- Multiple Myeloma Research and Treatments
- Traditional Chinese Medicine Analysis
- Gout, Hyperuricemia, Uric Acid
- Galectins and Cancer Biology
Anyang Normal University
2024
Chinese PLA General Hospital
2022-2023
Chinese People's Liberation Army
2023
Berry Oncology (China)
2022-2023
Baogang Group (China)
2022-2023
Qiqihar Medical University
2008-2022
Second Affiliated Hospital of Zhejiang University
2018-2019
Beijing Institute of Genomics
2014-2018
Chinese Academy of Sciences
2011-2018
University of Chinese Academy of Sciences
2018
Induced pluripotent stem cells (iPSCs) and embryonic (ESCs) share many common features, including similar morphology, gene expression in vitro differentiation profiles. However, genomic stability is much lower iPSCs than ESCs. In the current study, we examined whether changes DNA damage repair are responsible for their greater tendency towards mutagenesis.Mouse iPSCs, ESCs fibroblasts were exposed to ionizing radiation (4 Gy) introduce double-strand breaks. At 4 h later, fidelity of was...
Abstract Pulmonary cryptococcosis (PC) is a common fungal infectious disease, and infection can occur in patients with any immune function. To better understand PC, we compared the CT findings histopathological results immunocompetent immunocompromised patients. The clinical data of 68 PC were collected retrospectively divided into group group. characteristics, manifestations characteristics two groups compared. Forty-two (61.8%) immunocompetent, 26 (38.2%) immunocompromised. Compared...
Aim: Cancer stem cells (CSCs) drive triple-negative breast cancer recurrence via their properties of self-renewal, invasiveness and radio/chemotherapy resistance. This study examined how CSCs might sustain these properties. Materials & methods: Transcriptomes, DNA methylomes histone modifications were compared between non CSCs. Results: Transcriptome analysis revealed several pathways that activated in CSCs, whereas cell cycle regulation inhibited. Cell development signaling genes...
Bacterial resistance to antimicrobial agents, including multidrug resistance, is an increasing problem in the treatment of infectious diseases. The development resistance-modifying agents represents a potential strategy alleviate spread bacterial antibiotics. A checkerboard microdilution assay was used determine synergy jatrorrhizine and antibiotic, norfloxacin (NFX). ethidium bromide efflux assay, reverse transcription semi-quantitative polymerase chain reaction analysis molecular docking...
As a diagnostic biomarker, prostate special antigen (PSA) tests always generate false positive results and lead to unnecessary and/or repeat biopsies. Therefore, there is an urgent need for developing more sensitive, specific biomarkers. We epigenotyped methylated sites in cancer tissues adjacent normal from 66 patients. In comparison with tissues, we observed that were 6 aberrant methylation on the Y-chromosome. further performed pyrosequencing using urine of PCa patients identified one...
Pulmonary hypertension (PH) is a progressive and serious disease, where exacerbated inflammatory response plays critical role. Isoliquiritigenin (ISL), an important flavonoid isolated from Glycyrrhizae radix, exhibits wide range of pharmacological actions including anti-inflammation. Previously we found ISL alleviated hypoxia-induced PH; in the present study, to extend this, evaluated effects on monocrotaline (MCT)-induced PH relevant mechanisms. Rats received single intraperitoneal...
Atherosclerosis is a chronic inflammatory disease implicated in oxidative stress and endothelial dysfunction. Protein disulfide-isomerase A3 (PDIA3) has been reported to regulate suppress inflammation. This study aimed explore the function of PDIA3 atherosclerosis underlying mechanisms. expression oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein cells (HUVECs) was detected using RT-qPCR Western blotting. Following knockdown through transfection with small interfering...
People living with human immunodeficiency virus (PLWH) are a vulnerable population higher risk of severe coronavirus disease 2019 (COVID-19); therefore, vaccination is recommended as priority. Data on viral reservoirs and immunologic outcomes for PLWH breakthrough infected acute respiratory syndrome 2 (SARS-CoV-2) currently limited. In this study, we investigated the effects SARS-CoV-2 infection hematological parameters, (HIV) reservoir size, T-cell recovery in receiving antiretroviral...
Background: We aimed to investigate the effect of probiotic VSL#3 on NF-κB and TNF-α in rats with colitis correlation TLR4-NF-κB signal pathway. Methods: Sixty Sprague Dawley (SD) were divided into control, model therapy groups (n=20) according random number table. Rats modeled for colitis, group intragastrically administered VSL#3. The expression TLR4 protein, levels NF-κB, TLR4, mRNA colon tissue detected. concentration serum after modeling but before intragastric administration (T0), 3d...
Objective Coronary artery disease (CAD) is a multifactorial and polygenic disease. The aim of this study was to examine the association between six polymorphisms four alcohol metabolism relevant genes (ADH1B, ADH1C, ALDH1b1, ALDH2) risk CAD in Han Chinese. Methods Results This hospital-based case-control involving 1365 hypertensive patients. All subjects were angiographically confirmed. Genotypes determined with ligase detection reaction method. There no observable deviation from...
The protein kinase, TANK-binding kinase 1 (TBK1), not only regulates various biological processes but also functions as an important regulator of human oncogenesis. However, the detailed function and molecular mechanisms TBK1 in hepatocellular carcinoma (HCC), especially resistance HCC cells to molecular-targeted drugs, are almost unknown. In present work, role regulating sensitivity drugs was measured by multiple assays. high expression identified clinical specimens compared with paired...
Abstract Liver disease is an important that seriously threatens human health. It accounts for the highest proportion in various malignant tumors, and its incidence rate mortality are on rise, affecting Modern imaging has developed rapidly, but application of image segmentation liver tumor surgery still rare. The processing technology represented by artificial intelligence (AI) can greatly improve efficiency surgery, reduce surgical complications, cost surgery. Hepatocellular carcinoma most...
In the West, safety and efficacy of Lotus valve have been demonstrated; however, data in Chinese population are still lacking. Few studies compared clinical outcomes transcatheter aortic replacement (TAVR) with patients bicuspid or tricuspid stenosis. Our aim was to assess TAVR a patient cohort.In total, 23 symptomatic, high-surgical risk severe stenosis were enrolled. Among them, nine (39%) had valves, three large annulus dimension. The successfully implanted all patients. To facilitate...
This study aimed to investigate and analyze the risk of pulmonary infection after laparoscopic surgery detection results drug-resistant bacteria. With technology developing rapidly in recent years people’s minimally invasive concept improving continuously, radical has been widely used treatment a variety diseases. Laparoscopic probability causing complications. In order avoid this, factors were analyzed, bacteria analyzed for accurate prevention treatment. A total 600 patients who underwent...