A5100672216- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- RNA Research and Splicing
- DNA Repair Mechanisms
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Renal Transplantation Outcomes and Treatments
- Plant Reproductive Biology
- Cancer, Lipids, and Metabolism
- Genomics and Chromatin Dynamics
- Plant tissue culture and regeneration
- Genetic and phenotypic traits in livestock
- Genetic Syndromes and Imprinting
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Metabolism and Genetic Disorders
- Lung Cancer Treatments and Mutations
- Machine Learning in Bioinformatics
- Genetic Associations and Epidemiology
- Endometriosis Research and Treatment
- Developmental Biology and Gene Regulation
Sichuan University
2018-2025
West China Second University Hospital of Sichuan University
2018-2025
Affiliated Hospital of Guizhou Medical University
2023
Heilongjiang Provincial Academy of Agricultural Sciences
2023
Nanchang University
2014-2023
Tang Du Hospital
2022-2023
Guiyang Medical University
2023
Xi'an Technological University
2023
German Cancer Research Center
2016-2022
Tianjin Chengjian University
2022
Abstract DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation identify mortality-related DNAm signatures general population-based cohort with up 14 years follow-up. In the discovery panel case-cohort approach, 11,063 CpGs reach genome-wide significance (FDR<0.05). 58 CpGs, mapping 38 well-known disease-related genes intergenic regions, are confirmed panel. A mortality risk score based on ten selected...
Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax receptor 2) are strongly correlated with susceptibility. Previous studies found that transcript abundance varies considerably in individuals different ethnic/geographical groups, but no eQTLs (expression quantitative trait loci) have been identified. By using 3C (chromatin conformation capture), CRISPR-mediated genomic deletion dual-luciferase reporter assay, gene loci containing cis-regulatory elements were...
The aberrant activation of the Notch signaling has been associated with development colon cancers. However, role Notch1 in pathogenesis cancers is poorly understood.The expression cancer tissues and nontumor cell lines was examined by Western blot analysis immunohistochemistry. impact small interfering RNA (siRNA)-mediated knockdown or intracellular domain (NICD)-based transgene-induced overexpression on proliferation, cycling, apoptosis, colony formation, tumorsphere formation vitro growth...
Newly established blood DNA methylation markers that are strongly associated with smoking might open new avenues for lung cancer (LC) screening. We aimed to assess the performance of top hits from previous epigenome-wide association studies in prediction LC incidence. In a prospective nested case-control study, at AHRR (cg05575921), 6p21.33 (cg06126421), and F2RL3 (cg03636183) were measured by pyrosequencing baseline whole samples 143 incident cases identified during 11 years follow-up 457...
DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling. Differentially methylated regions (DMRs) have important implications for development, aging diseases. Therefore, genome-wide mapping of DMRs across various temporal spatial methylomes is revealing the impact epigenetic modifications on heritable phenotypic variation. We present a quantitative approach, differentially (QDMRs), to quantify difference identify from profiles by adapting Shannon entropy....
Anthocyanins are plant pigments with diverse biological functions that contribute to fruit quality and beneficial human health. Anthocyanin accumulation can be influenced by environmental signals, such as light, plants have developed sophisticated systems receive transduce these signals. However, the associated molecular mechanisms not well understood. In this study, we investigated potential function of mitogen-activated protein kinases, which members light signaling pathway, during...
Hybrid vigor is highly valued in the agricultural industry. Male sterility an important trait for crop breeding. Pollen development under strict control of both gametophytic and sporophytic factors, defects this process can result male sterility. Both dicot Arabidopsis moncot rice, proper timing programmed cell death (PCD) tapetum ensures pollen development. Dynamic ROS levels have been reported to tapetal PCD, thus development, rice. However, it was unclear whether evolutionarily conserved,...
<p id="p00010">There is a close relationship between peer victimization and internalizing problems in children adolescents. According to the interpersonal risk model, negative experiences, such as victimization, are important stressors, they leave with their basic need for belonging unsatisfied so lead series of problem behaviors. The symptom-driven model emphasizes that leaves individuals vulnerable attack, factors predicting victimization. interaction shows childhood adolescence...
Background Numerous researches have investigated the correlation between single nucleotide polymorphisms (SNPs) in transcription factor forkhead box protein 3 (Foxp3) gene and development of various cancers. However, relationship Foxp3 polymorphism bladder cancer (BC) remain unclear. Method This hospital-based case-control study enrolled a total 316 patients diagnosed with BC 643 healthy controls. Two SNPs (rs3761548 C/A, rs5902434 del/ATT) were selected, genotyping samples was performed...
Epigenome‐wide association studies have established methylation patterns related to smoking, the major risk factor of lung cancer (LC), which are distinct from profiles disclosed in LC patients. This study simultaneously investigated associations smoking‐associated and LC‐related markers with mortality. DNA was determined by HM450K assay baseline blood samples 1,565 older adults a population‐based case–cohort study. The 151 CpGs (smoCpGs) 3,806 (caCpGs) mortality were assessed weighted Cox...
Abstract Background The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures age-related physiological changes reflected in status. Several studies have linked DNAmAA to morbidity mortality, yet its relationship with kidney function has not been assessed. We evaluated the associations seven DNAm aging lifespan predictors (as well as GrimAge components) five traits...
// Tianzhen Wang 1, * , Yan He Yuanyuan Zhu 2, Mingwei Chen 3, Mingjiao Weng 1 Chao Yang Zhang 4 Ning 5 Ran Zhao Weiwei Yinji Jin Jing Li Riju James Rajkumar Ezakiel Redpath Lei Xiaoming Zhaohua Zhong 6 Fengmin Yunwei Wei 7 Guomin Shen 8 Dong 9 Ying Liu Guangyu 2 Xiaobo 10 Department of Pathology, Harbin Medical University, Harbin, China Gastrointestinal Oncology, the Affiliated Tumor Hospital 3 Anatomy, Nutrition and Food Hygiene, Public Health College, Surgery, International Pecking...
Abstract Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident rarely investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2′-deoxyguanosine, were assessed 8,793 older adults a population-based German cohort. 1,540 cases, 207 lung, 196 colorectal, 218 breast 245 prostate cases diagnosed during over 14 years of follow-up....
The high-frequent pulsing ablation of C/C−SiC−ZrB2−ZrC composites under millisecond-scaled single loading for different cycles was studied. sample ablated and cooled by plasma airflow alternately on a self-developed bench. Results indicated that the rates decreased quickly before 1000 then declined gradually until impact 2000 cycles. Microstructure, phase surface temperature analyses suggested an incomplete layer mixed ceramic product formed surfaces tested amount bare carbon tended to be...