A5101821047- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Hypoxia, and Metabolism
- Soil and Unsaturated Flow
- DNA Repair Mechanisms
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Heme Oxygenase-1 and Carbon Monoxide
- Glycosylation and Glycoproteins Research
- Kawasaki Disease and Coronary Complications
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- Geotechnical Engineering and Analysis
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
Chinese Academy of Sciences
2016-2025
Beijing Institute of Genomics
2016-2025
Shanghai Center For Bioinformation Technology
2021-2025
Yellow River Institute of Hydraulic Research
2024
Fuzhou University
2022
Fujian Institute of Research on the Structure of Matter
2022
Foshan University
2022
University of Chinese Academy of Sciences
2017-2018
Air Force Medical University
2013
Xijing Hospital
2013
Background The immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial in maintaining a delicate balance between protective effects and harmful pathological reactions that drive the progression of disease 2019 (COVID-19). T cells play significant role adaptive antiviral responses, making it valuable investigate heterogeneity diversity SARS-CoV-2-specific cell COVID-19 patients with varying severity. Methods In this study, we employed high-throughput...
Induced pluripotent stem cells (iPSCs) and embryonic (ESCs) share many common features, including similar morphology, gene expression in vitro differentiation profiles. However, genomic stability is much lower iPSCs than ESCs. In the current study, we examined whether changes DNA damage repair are responsible for their greater tendency towards mutagenesis.Mouse iPSCs, ESCs fibroblasts were exposed to ionizing radiation (4 Gy) introduce double-strand breaks. At 4 h later, fidelity of was...
The plasma protein hemopexin (HPX) exhibits the highest binding affinity to free heme. In vitro experiments and gene-knock out technique have suggested that HPX may a neuroprotective effect. However, expression of in brain was not well elucidated its after cerebral ischemia-reperfusion injury also poorly studied. Furthermore, no vivo data were available on effect given centrally prognosis focal ischemia. present study, we systematically investigated normal rat by immunofluorescent staining....
Aim: Cancer stem cells (CSCs) drive triple-negative breast cancer recurrence via their properties of self-renewal, invasiveness and radio/chemotherapy resistance. This study examined how CSCs might sustain these properties. Materials & methods: Transcriptomes, DNA methylomes histone modifications were compared between non CSCs. Results: Transcriptome analysis revealed several pathways that activated in CSCs, whereas cell cycle regulation inhibited. Cell development signaling genes...
The metabolic reprogramming is indispensible for the fast growth of tumor cells. metabolism CAFs reprogrammed to aerobic glycolysis too. However, it not clear whether this promotes themselves. In study, we found that proliferation rate was slower than NAFs, which determined by cell counting, BrdU assay and flow cytometry analysis. Moreover, TGF-β signaling regulated CAF through RNA-sequencing analysis Western blot, further supported observation TGF-β2 highly expressed in colon cancer...
Color-tunable organic solid-state luminescent materials have received increasing attention owing to their potential applications in displays, imaging, encryption, etc. To provide more information about structure-packing-property relationship of color-tunable luminophores, molecules with definite structures and explicit molecular packing are highly desired. In this work, we present an strategy realize luminescence by using the molecule 1-(4-carboxyphenyl)-4,4′-bipyridinium (CPB) as building...
Abstract Identification and characterization of methylation quantitative trait loci (mQTLs) can help elucidate the role DNA changes as a potential mediator genetic risk loci. However, mQTLs remain poorly characterized: they have not yet been mapped in largest ethnic populations, their cell-type specific nature has resolved, proportion attributed to different molecular mechanisms is unknown. Here we perform first mQTL-mapping study large Han Chinese population, demonstrating that over 80% are...