A5101919687- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Hepatitis B Virus Studies
- S100 Proteins and Annexins
- Pediatric Hepatobiliary Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medicinal Plant Pharmacodynamics Research
- Congenital Heart Disease Studies
- Congenital Anomalies and Fetal Surgery
- Kruppel-like factors research
- Gallbladder and Bile Duct Disorders
Inner Mongolia Medical University
2006-2024
Beijing Xuanwu Traditional Chinese Medicine Hospital
2019-2020
Pancreatic cancer (PaC) is highly associated with diabetes mellitus (DM). However, the mechanisms are insufficient. The study aimed to uncover underlying regulatory mechanism on diabetic PaC and find novel biomarkers for disease prognosis. Two RNA-sequencing (RNA-seq) datasets, GSE74629 GSE15932, as well relevant data in TCGA were utilized. After pretreatment, differentially expressed genes (DEGs) or miRNAs (DEMs) lncRNAs (DELs) between non-diabetic patients identified, further examined...
Long noncoding RNA small nucleolar host gene 1 (lncRNA SNHG1) plays a crucial role in the occurrence and progression of various tumors. This study investigates function lncRNA SNHG1 hepatocellular carcinoma (HCC). We discovered that is significantly upregulated HCC markedly enhances cell proliferation, migration, invasion, while simultaneously suppressing apoptosis cells. Furthermore, was found to downregulate miR-7-5p expression. Overexpression counteracted suppression invasion caused by...
Cervical cancer is one of the most common gynecological cancers. Cisplatin resistance remains a major hurdle in successful treatment cervical cancer. Aberrant expression long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are implicated cisplatin resistance. However, regulatory functions lncRNAs miRNAs underlying mechanisms still elusive. Our qRT-PCR assays verified that miR-206 levels were down-regulated cisplatin-resistant cells. The introduction sensitized cells to cisplatin. luciferase...
The acquisition of cancer stem-like properties is believed to be responsible for metastasis and therapeutic resistance in cervical (CC). CC tissues display a high expression level hexokinase 2 (HK2), which critical the proliferation migration cells. However, little known about functional role HK2 maintenance stem cell-like ability cisplatin Here, we showed that significantly elevated tissues, correlates with poor prognosis. overexpression (or knockdown) can promote inhibit) sphere-forming In...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. In past decades, HCC treatment has achieved great progress; however, overall prognosis remains poor. Therefore, it need hour to identify new prognostic biomarkers which can advance our understanding related underlying molecular mechanism adverse and apply them clinical work in prediction. present study, data 576 patients 292 normal control cases from TCGA ICGC databases were enrolled bioinformatic...
Objective To study the role of long non-coding RNA H19 in chemosensitivity colorectal cancer. Methods The colon cancer cell lines stably overexpressed and silenced with lncRNA were constructed cultured 5-FU. The expression was detected by RT-qPCR. proliferation rate measured MTT assay. migration ability each group evaluated scratch test. protein expressions MDR1, MRP1 BCRP Western blot. Results Compared normal cells, increased, stable overexpression significantly higher than...
Abstract Background: Neutrophil infiltration and phenotypic transformation are believed to contribute neuronal damage clinical outcome in ischemic stroke. Emerging evidence suggests that HDAC2 is an epigenetic regulator of inflammatory cells. Here, we investigated whether miR-494 affects HDAC2-mediated neutrophil shift. Methods: The levels neutrophils from AIS patients were detected by real-time PCR. C57BL/6J mice subjected transient middle cerebral artery occlusion, the N1/N2 shift was...
Congenital absence of gallbladder and atrial septal defect (ASD) are clinically rare congenital organ malformations, the simultaneous occurrence two is even more rare. The present study reported a case agenesis combined with ASD. A 38-year-old male patient presented 3-year history recurring upper right abdominal pain. pain had no evident cause was accompanied by dyspepsia gasteremphraxis indigestion. Several color Doppler ultrasonography scans revealed cholecystitis stones. physical...
Severe acute biliary pancreatitis can be treated by nonsurgical and surgical approaches,and choice of the techniques as well its timing are keys points to whole therapy.Early enteral nutrition via placing nasointestinal feeding tube plays an important role in nutritional support for patients with severe pancreatitis.This paper intends explore experience standardizing therapy all similar cases reviewing summarizing treating process a typical patient pancreatitis. Key words: Severe...
Objective To compare the clinical outcome of Endoscopic Nasobiliary Drainage(ENBD), Retrograde Biliary Drainage (ERBD) and Percutaneous Transhepatic Cholangial Drainage(PTCD) in preoperative treatment elderly patients with type Ⅲ~Ⅳ hilar cholangiocarcinoma. Methods Clinical data 66 cholangiocarcinoma, who received biliary drainage from January 2013 to December 2018, were analyzed retrospectively. According different kinds drainage, divided into PTCD group, ERBD group ENBD group. All...
Abstract Background: Inflammation affect long-term neurological outcome after acute ischemic stroke (AIS). Comprehensive and insightful understanding of correlation inflammatory mediators may offer new biomarkers or therapeutic approaches for AIS. Methods: We collected plasma from in 204 AIS patients 76 healthy controls, ten cytokines (HGF, IL-1β, IL-2, sIL-2R, IL-5, IL-10, IL-16, MIP-3α, CD40L MMP1) screened out by Immune Monitoring 65-Plex Human ProcartaPlex Panel were measured. Functional...
To investigate the molecular mechanism by which pirfenidone inhibits scar formation through TGF-β/Smad pathway.Cultured rabbit tenon fibroblasts (RTFs) were treated with different concentrations of to determine its initial active concentration and optimum for inhibiting RTF proliferation using CCK-8 assay. In RTFs at optimal concentrations, expressions TGF-β3, collagen I III examined both immunofluorescence assay Western blotting, their mRNA expression levels detected RT-PCR.The 0.1 mg/mL...