In this study, a calcium-binding peptide was obtained by hydrolyzing tilapia bone and its osteogenic activity evaluated. Animal protease selected from nine enzymes, hydrolysate purified through preparative semi-preparative reverse phase high-performance liquid chromatography. The identified as DGPSGPK (656.32 Da) capacity reached 111.98 µg/mg. calcium chelate (DGPSGPK-Ca) obtained, structure characterized Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning...

Intelligent game-based learning environments have developed and created dynamic, effective, engaging experiences, serving as a tutoring framework for students of different educational levels. Although features recently been shown to the potential improve intelligent systems in these environments, there remains some debate challenges terms their benefits learning. Therefore, this study, we aim identify categories explore how particular influence students' environments. To achieve goal,...

Long noncoding RNA small nucleolar host gene 1 (lncRNA SNHG1) plays a crucial role in the occurrence and progression of various tumors. This study investigates function lncRNA SNHG1 hepatocellular carcinoma (HCC). We discovered that is significantly upregulated HCC markedly enhances cell proliferation, migration, invasion, while simultaneously suppressing apoptosis cells. Furthermore, was found to downregulate miR-7-5p expression. Overexpression counteracted suppression invasion caused by...

Glucagon-like peptide-1 receptor agonist liraglutide may have beneficial effects on atherosclerosis development in impaired glucose tolerance (IGT). To the best of our knowledge, however, little conclusive evidence from clinical trials has been presented. The present study aimed to investigate effect progression patients with IGT. was a double-blind, randomized controlled trial. A total 39 aged 20-75 years who were overweight or obese (BMI, 27-40 kg/m2) and presented IGT receive (n=17)...

Abstract This study aimed to explore how kinesin family member 2C (KIF2C) influences the progression of non-small cell lung cancer (NSCLC). The levels KIF2C and microRNA-186-3p (miR-186-3p) were examined by quantitative real-time polymerase chain reaction (qRT-PCR). Through utilization counting kit-8 (CCK-8) assay, colony formation wound closure Transwell NSCLC proliferation, migration, invasion identified, respectively. apoptosis was assessed using TUNEL assay flow cytometry (FCM) assay....


 The digital revolution and globalization have a deep influence on education at all levels. Various devices do not only provide students’ Internet connections, but also create more opportunities for them to get inspired, motivated, engaged in learning activities. Recent research shows that triggering interest can enhance self-regulation, collaboration, problem-solving, joy of learning. Previous studies show the pedagogical use information communication technology (ICT) support...

Tilapia skin gelatin hydrolysates (TSGH) were obtained by complex protease hydrolysis. The amino acid sequences of 50 peptides in TSGH identified, and most these found to contain the -Gly-Pro-sequence. osteoporosis (OP) rat model induced retinoic was prepared, effects different doses on OP vivo evaluated. Serum calcium (Ca) phosphate (P), alkaline phosphatase activity, osteocalcin levels rats regulated TSGH. bone length, dry weight index, maximum load, Ca content significantly increased...

Abstract Aims To explore women's and health professionals' views on the development of a midwifery‐led mHealth app intervention in antenatal care their demands for functionality. Design Descriptive qualitative research was utilized. Methods In total, 15 pregnant or postpartum women were interviewed via in‐depth interviews 10 professionals including obstetricians, midwives obstetric nurses invited to participate focus group discussion (FGD). All FGD analysed using content analysis. Results...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. In past decades, HCC treatment has achieved great progress; however, overall prognosis remains poor. Therefore, it need hour to identify new prognostic biomarkers which can advance our understanding related underlying molecular mechanism adverse and apply them clinical work in prediction. present study, data 576 patients 292 normal control cases from TCGA ICGC databases were enrolled bioinformatic...

Stillbirth occurs in about 1 of every 200 pregnancies. Suggestions have been made that it can be prevented through use increased antenatal surveillance and intervention for risk factors such as advanced maternal age, but there is little supporting evidence this practice. The aim retrospective study was to identify potential prepregnancy antepartum stillbirth determine whether these are useful identifying women at a significantly higher term compared with those the general population not...

Previous studies have shown that human crystallin alpha B (CRYAB) is highly expressed in cancers and associated with poor survival cancer patients. Here we investigated whether SLC39A11 CRYAB genes were related to the proliferation development of lung adenocarcinoma (LUAD) explore their potential as therapeutic targets prognostic markers for LUAD.CRYAB identified from The Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) database. cell lines A549 H1975 cultured, transfected,...

This study attempts to provide an in-depth understanding of the influence collaborative digital gameplay on students’ behavioural, emotional and cognitive engagement in mathematics. mixed-method used pre- (N = 45) post-test 43) surveys photo-elicitation interviews 6) investigate how a six-day experiment involving Wuzzit Trouble affects The quantitative results showed did not elicit significant increase mathematics from pre-test post-test. Moreover, qualitative analyzing measurement...

Wood is one of the main building materials. However, defects on veneers result in substantial waste wood resources. Traditional veneer defect detection relies manual experience or photoelectric-based methods, which are either subjective and inefficient need investment. Computer vision-based object methods have been used many realistic areas. This paper proposes a new deep learning pipeline. First, an image collection device constructed total more than 16,380 images collected coupled with...

This paper presents an optimization model for water quantity and quality integrated management of urban lake in a deficient city. A representative safeguard system served lake, including multi-source supply facilities, recirculating purification facilities surplus discharge is widely used Chinese cities. Because it complicated, any mismanagement will result deterioration, waste high operation cost. The presented attempts to achieve the objectives controlling pollution, reducing economic cost...

The purpose of this study was to explore transrectal ultrasound (TRUS) findings prostate cancer (PCa) guided by multiparametric magnetic resonance imaging (mpMRI) and improve the Prostate Imaging Reporting Data System (PI-RADS) system for avoiding unnecessary mpMRI-guided targeted biopsy (TB). From January 2018 October 2019, fusion mpMRI TRUS-guided biopsies were performed in 162 consecutive patients. included 188 suspicious lesions on 156 patients, all whom underwent mpMRI-TRUS...