A5100421069- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Climate change and permafrost
- Microbial Community Ecology and Physiology
- Plant Virus Research Studies
- Genetic and Environmental Crop Studies
- Plant Molecular Biology Research
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Bioenergy crop production and management
- Viral Infections and Immunology Research
- GABA and Rice Research
- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Soybean genetics and cultivation
- Urological Disorders and Treatments
- Agricultural pest management studies
- Plant Stress Responses and Tolerance
- Evolutionary Game Theory and Cooperation
- Sexual Differentiation and Disorders
- RNA modifications and cancer
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2025
Chengdu University of Traditional Chinese Medicine
2025
Beijing Forestry University
2020-2024
University of Bern
2021-2024
SIB Swiss Institute of Bioinformatics
2021-2024
Anhui Academy of Agricultural Sciences
2023-2024
Chinese Academy of Sciences
2013-2024
Shanxi Normal University
2024
Institute of Tibetan Plateau Research
2024
Lanzhou University
2024
A Gram-stain-negative, facultatively anaerobic, gliding, yellow-pigmented bacterium, designated SS12(T), was isolated from shark gill homogenate and characterized using a polyphasic approach. The strain catalase-positive oxidase-negative. Optimal growth occurred at 28-30 °C, pH 7.0-7.5 in the presence of 2-4% (w/v) NaCl. DNA G+C content 40.0 mol%. contained MK-7 as prevailing menaquinone; iso-C15 : 0 anteiso-C15 major cellular fatty acids; phosphatidylethanolamine an unknown lipid...
Urophysa is a Chinese endemic genus comprising two species, rockii and henryi. In this study, we sequenced the complete chloroplast (cp) genomes of these species their relative Semiquilegia adoxoides. Illumina sequencing technology was used to compare sequences, elucidate intra- interspecies variations, infer phylogeny relationship with other Ranunculaceae family species. A typical quadripartite structure detected, genome size from 158,473 158,512 bp, consisting pair inverted repeats...
Tree peony (Paeonia ostii) is an economically important ornamental plant native to China. It also notable for its seed oil, which abundant in unsaturated fatty acids such as α-linolenic acid (ALA). Here, we report chromosome-level genome assembly (12.28 Gb) of P. ostii. In contrast monocots with giant genomes, tree does not appear have undergone lineage-specific whole-genome duplication. Instead, explosive LTR expansion the intergenic regions within a short period (~ two million years) may...
Viral vector-mediated gene transfer into the heart represents a potentially powerful tool for studying both cardiac physiology as well therapy of disease. We report here use defective viral vector, which expresses no products, mammalian heart. Previous studies have used recombinant vectors, retained genes and yielded mostly short-term expression, often with significant inflammation.An adeno-associated virus vector was that contains is completely free contaminating helper viruses. The applied...
Populus tomentosa, an indigenous tree species, is widely distributed and cultivated over 1,000,000 km
The MYB transcription factor (TF) is one of the largest gene families in plants and involved to multiple biological processes. However, little known about family its functional role genome moso bamboo. In present study, a total 114 R2R3MYB genes were first identified from bamboo full-length non-chimeric (FLNC) reads. Phylogenetic analysis coupled with structure motif determination resulted division these PheR2R3MYBs into 17 subgroups. position eight proteins along an external branch...
Background Cathepsins, a family of lysosomal proteases, have been implicated in Alzheimer's disease (AD) pathogenesis through their involvement amyloid-β protein precursor processing and neuroinflammation. However, the specific roles different cathepsins AD remain unclear. Objective This study aimed to investigate genetic associations potential causal relationships between AD, using Mendelian randomization (MR) explore as biomarkers therapeutic targets. Methods A two-sample MR analysis was...
How does standing genetic variation affect polygenic adaptation in recombining populations? Despite a large body of work quantitative genetics, epistatic and weak additive fitness effects among simultaneously segregating variants are difficult to capture experimentally or predict theoretically. In this study, we simulated on landscapes with tunable ruggedness driven by populations. We confirmed that recombination hinders the movement population through rugged landscape. When surveying effect...
Domestication is the long and complex process underlying evolution of crops, in which artificial directional selection transformed wild progenitors into desired form, affecting genomic variation leaving traces at targeted loci. However, whether genes controlling important domestication traits follow same evolutionary pattern expected under standard selective sweep model remains unclear. With whole-genome resequencing mungbean (Vigna radiata), we investigated this issue by resolving its...
Abstract Genetic dissection of agronomic traits is important for crop improvement and global food security. Phenotypic variation tassel branch number (TBN), a major breeding target, controlled by many quantitative trait loci (QTLs). The lack large-scale QTL cloning methodology constrains the systematic TBN, which hinders modern maize breeding. Here, we devise QTG-Miner, multi-omics data-based technique rapid genes (QTGs) in maize. Using clone verify seven underlying TBN QTLs. Compared to...
An aerobic bacterial strain designated AX-7T was isolated from the trunk surface of a Japanese beech (Fagus crenata). Cells were Gram-stain-negative, non-spore-forming, non-motile rods (1.0-1.2 µm in width and 1.2-3.0 length) with peritrichous fimbriae. capsulated, number them surrounded by thick slime layer. During growth, large aggregates formed, culture medium became viscous probably owing to exopolysaccharide release The temperature range for growth 10-37 °C, an optimum at 30 °C. pH...
Dobzhansky-Muller incompatibilities (DMIs) are a major component of reproductive isolation between species. DMIs imply negative epistasis and exposed when two diverged populations hybridize. Mapping the locations has largely relied on classical genetic mapping. Approaches to date hampered by low power challenge identifying DMI loci same chromosome, because strong initial linkage parental haplotypes weakens statistical tests. Here, we propose new statistics infer from haplotype frequencies in...
Abstract The Tibetan Plateau holds the world's largest alpine permafrost and is undergoing an acceleration of warming. Phenological shifts over in a warmer world have been little studied are greatly underrepresented current syntheses. Here, we conducted seasonal gradient temperature‐controlled experiments permafrost‐affected meadow to evaluate how warming drives spring autumn phenology, associated growing‐season length at both community species levels. We found that there no sign slowdown...
Base editors of the Cas9 system have been widely used for precise nucleotide substitution in crops. In this study, Cas12a was applied to construct plant cytosine base (CBEs). The main elements Cas12a-CBEs were engineered and their efficiency evaluated stably transformed rice cells. An optimized ttCas12a-hyA3Bctd editor, consisting a LbCas12a variant carrying catalytic inactive D832A temperature-tolerance D156R double mutations, truncated human APOBEC3B deaminase, RAD51 single-stranded...
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders mainly caused by defect in the steroid 21-hydroxylase gene (CYP21A2). In this study, we investigated molecular defects 25 Chinese pedigrees with deficiency (21-OHD). Diagnosis probands families was based on their typical clinical presentations, such as inborn ambiguous genitalia, or early onset salt wasting and biochemical metabolite abnormalities. All 10 exons exon–intron boundaries CYP21A2 were amplified from...
A novel bacterial strain, designated Y11 T , was isolated from marine sediment at Weihai in China. Comparative analysis of 16S rRNA gene sequences demonstrated that the isolate showed highest similarity to Saccharicrinis fermentans DSM 9555 (94.0 %) and carchari SS12 (92.7 %). Strain a Gram-stain-negative, rod-shaped, non-endospore-forming, yellow-pigmented bacterium able hydrolyse agar weakly. It catalase-negative, oxidase-positive, facultatively anaerobic motile by gliding. Optimal growth...