A5100442273- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Heart Rate Variability and Autonomic Control
- Congenital heart defects research
- Signaling Pathways in Disease
- Vagus Nerve Stimulation Research
- Ion channel regulation and function
- Pluripotent Stem Cells Research
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Cardiovascular Function and Risk Factors
- Nerve injury and regeneration
- Cardiac Ischemia and Reperfusion
- Parkinson's Disease Mechanisms and Treatments
- Tissue Engineering and Regenerative Medicine
- S100 Proteins and Annexins
- Heat shock proteins research
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
Wuhan University
2015-2024
ShanghaiTech University
2024
Dalian Medical University
2015-2024
Cardiovascular Institute Hospital
2012-2024
Chinese University of Hong Kong, Shenzhen
2024
Renmin Hospital of Wuhan University
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Huazhong University of Science and Technology
2023
Zhejiang University
2023
Peking Union Medical College Hospital
2015-2022
Brain-derived neurotrophic factor (BDNF) has critical functions in promoting survival, expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation mechanism is still not fully understood. The role BDNF proliferation NSCs through Wnt/β-catenin signaling was studied via cell culture cortical NSCs, Western blotting, immunocytochemistry, TOPgal (Wnt reporter) analysis mice. First, stimulated NSC dose dependently cultured neurospheres that exhibited BrdU...
The aim of this study was to evaluate the changes in cognitive performance migraine patients using a comprehensive series cognitive/behavioral and electrophysiological tests. A randomized, cross-sectional, within subject approach used compare neuropsychological evaluations from migrane-affected healthy subjects. Thirty-four with (6 males, 28 females, average 36 years old) were included. Migraineurs performed worse majority Montreal Cognitive Assessment (MoCA) (p = 0.007) compared subjects,...
CPL active materials with a tunable g lum -factor, from −0.30 to 0.04, were fabricated by incorporating responsive organic dye into cellulose nanocrystals. Such films showed dynamic switchable signal in intensity and handedness at different pH.
To determine whether Salmonella Typhimurium (STM)in gastrointestinal tract can induce the functional activation of brain, vagus nerve involves in signaling immune information from to brain and how it influences function under natural infection condition.Animal model rat was established by an intubation (STM) into stomach mimic condition bacteria infection. Subdiagphragmatic vagotomy performed some animals 28 days before The changes Fos expression visualized with immunohistochemistry...
Relapse to drug seeking was studied using a rodent model of reinstatement induced by exposure drug-related cues. The mammalian target rapamycin (mTOR), serine/threonine protein kinase that regulates cell growth and survival controlling translation in response nutrients factors, has been demonstrated be involved neuronal adaptations underlie addiction learning memory. We investigated the potential role mTOR signaling pathway relapse cocaine cue-induced self-administering rats. found...
Activation of apoptosis signal-regulating kinase 1 (ASK1) is a key driving force the progression nonalcoholic steatohepatitis (NASH) and represents an attractive therapeutic target for NASH treatment. However, molecular cellular mechanisms underlying ASK1 activation in pathogenesis remain incompletely understood. In this study, our data unequivocally indicated that hyperactivated hepatocytes potent inducer hepatic stellate cell (HSC) by promoting production hepatocyte-derived factors. Our...
IMA-1 targets the ALOX12-ACC1 interaction to both prevent and treat NASH without inducing hyperlipidemia.
High-resolution soil moisture (SM) information is essential for regional to global hydrological and agricultural applications. The Soil Moisture Active Passive (SMAP) offers daily composites of SM at coarse-resolution 9 36 km, with data gaps limiting its local application depict distribution in detail. To overcome the aforementioned problem, a downscaling gap-filling novel approach was adopted, using random forest (RF) artificial neural network (ANN) algorithms downscale SMAP data,...
Aberrant increases in neuronal network excitability may contribute to the cognitive deficits Alzheimer's disease (AD). However, mechanisms underlying hyperexcitability are not fully understood. Such overexcitation of networks has been detected brains APP/PS1 mice. In present study, using current-clamp recording techniques, we observed that 12 days vitro (DIV) primary cultured pyramidal neurons from P0 mice exhibited a more prominent action potential burst and lower threshold than WT...
The short-chain fatty acid (SCFA) propionate (C3), a microorganism metabolite produced by gut microbial fermentation, has parasympathetic-activation effects. cardiac autonomic rebalancing strategy is considered as an important therapeutic approach to myocardial infarction (MI)-produced ventricular arrhythmias (VAs). Thus, our research was designed clarify the potential functions of SCFA in VAs and electrophysiology MI rats. A hundred adult Sprague-Dawley rats were allocated four groups: sham...
Wenxin Keli is the first state‑sanctioned traditional Chinese medicine (TCM)-based antiarrhythmic drug. The present study aimed to examine whether long‑term treatment with reduces ischemia‑induced ventricular arrhythmias in rats vivo, and if so, which mechanisms are involved. Male were treated either saline (control group) or for 3 weeks subjected myocardial ischemia 30 min assessment of resulting arrhythmias. L‑type calcium current (ICa,L) transient outward potassium (Ito) measured by patch...
Studies have shown that stellate ganglion nerve activity has association with atrial electrical remodelling and fibrillation (AF) inducibility, while median stimulation (MNS) decreases cardiac sympathetic drive. In this study, we tested the hypothesis MNS suppresses AF vulnerability.The effective refractory period (AERP) inducibility at baseline after 3 h of rapid pacing were determined in dogs undergoing (n = 7), MNS+ application methyllycaconitine 7) or sham procedure 6). Then, levels...
Aims: To investigate the role of KCa3. 1 inhibition in macrophage pro-inflammatory polarization and vulnerability to atrial fibrillation (AF) a canine model with prolonged rapid pacing. Materials Methods: Twenty beagle dogs (weighing 8–10 kg) were randomly assigned sham group ( n = 6), pacing 7) pacing+TRAM-34 7). An experimental AF was established by TRAM-34 administered Pacing+TRAM-34 slow intravenous injection (10 mg/kg), 3 times each day. After 7 days pacing, electrophysiology measured...
Background: Pharmacological therapy for congestive heart failure (CHF) with ventricular arrhythmia is limited. In the study, our aim was to evaluate effects of Chinese traditional medicine Shensong Yangxin capsules (SSYX) on rhythm and function in CHF patients frequent premature complexes (VPCs). Methods: This double-blind, placebo-controlled, multicenter study randomized 465 VPCs SSYX (n = 232) placebo groups 233) 12 weeks treatment. The primary endpoint monitored by a 24-h ambulatory...
Myocardial infarction (MI) leads to progressive left ventricular (LV) dilatation and is associated with interstitial fibrosis in the non-infarcted myocardium. The NF-κB signaling pathway plays an important role remodeling after MI. Recent studies have indicated that anti-malarial agent artemisinin can inhibit activation, which may attenuate post-infarct myocardial remodeling. In this study, we investigated effect of on using a rat model Adult male Sprague Dawley rats were divided into sham...
Although the function of cerebellum in neurocognition is documented, similar role brainstem underexplored. This clinical research aims to combine available neuropsychological assessments and P300 explore cognitive dysfunction affective impairment after stroke. 34 patients with isolated stroke 26 health controls were participated this experiment. The participants accepted assessment P300, ACE-III, MoCA, TMT, SDMT, DS, Stroop test SAS, SDS. Statistical analysis was carried out on two groups...
The primary mechanism underlying sepsis‑induced cardiac dysfunction is loss of endothelial barrier function. Neuregulin‑1 (NRG‑1) exerts its functions on multiple targets. present study aimed to identify the protective effects NRG‑1 in myocardial cells, including endothelial, anti‑inflammatory and anti‑apoptotic effects. Subsequent lipopolysaccharide (LPS)‑induced sepsis, rats were administered with either a vehicle or recombinant human (rhNRG‑1; 10 µg/kg/day) for one two days. H9c2...
The TBX3(T-box 3)transcription factor is considered as an essential in sinoatrial node formation. While the effect of TBX3 differentiation cells from embryonic stem cells(ESCs) has been recognized, its role human induced pluripotent cell derived cardiomyocytes(hiPSCMs) not addressed. Therefore, purpose present study was to investigate whether overexpression hiPSCs could increase their into pacemaker-like cells.The were transfected with gene during cardiomyocytes(CMs). hiPSCMs analyzed using...