A5101903743- Liver Disease Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Metabolism, Diabetes, and Cancer
- Acute Ischemic Stroke Management
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Diet, Metabolism, and Disease
- Space Science and Extraterrestrial Life
- Peptidase Inhibition and Analysis
- Neurological Disorders and Treatments
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Olfactory and Sensory Function Studies
- Glioma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- Venous Thromboembolism Diagnosis and Management
- Spaceflight effects on biology
- Animal Virus Infections Studies
- Space Exploration and Technology
- Light effects on plants
- Medical Research and Treatments
Cangzhou Central Hospital
2022-2024
Zhengzhou University
2023-2024
Ningbo University
2022-2023
Jiangxi University of Traditional Chinese Medicine
2023
Wuhan University
2020-2021
Renmin Hospital of Wuhan University
2020-2021
Zhengzhou Central Hospital
2020
Chinese Academy of Agricultural Sciences
2017
Lanzhou Veterinary Research Institute
2017
First Hospital of China Medical University
2014
Abstract For decades, lactate has been considered a byproduct of glycolysis. The shuttle hypothesis shifted the paradigm, demonstrating that not only plays important roles in cellular metabolism but also communications, which can transcend compartment barriers and occur within among different cells, tissues organs. Recently, discovery induce novel post-translational modification, named lysine lactylation (Kla), brings forth new avenue to study nonmetabolic functions for lactate, inspired...
IMA-1 targets the ALOX12-ACC1 interaction to both prevent and treat NASH without inducing hyperlipidemia.
Nonalcoholic fatty liver disease (NAFLD) is an emerging public health threat as the most common chronic worldwide. However, there remains no effective medication to improve NAFLD. G protein-coupled receptors (GPCRs) are frequently investigated drug targets family. The Regulator of protein signaling 14 (RGS14), essential negative modulator GPCR signaling, plays important regulatory roles in damage and inflammatory responses. role RGS14 NAFLD largely unclear.
Background and Aims Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease, which has no specific pharmacological treatments partially because of unclear pathophysiological mechanisms. Regulator G protein signaling (RGSs) proteins are that negatively regulate protein–coupled receptor (GPCR) signaling. The members R4/B subfamily smallest RGS in size, RGS5 belongs to this family, mediates pluripotent biological functions through canonical protein–mediated pathways...
ALOX12 drives NASH by inhibiting ACC1 lysosomal degradation across multiple species.
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the leading causes digestive system tumor related death in world. Unfortunately, effective chemopreventive agent lack for patients with ESCC clinical practice, which leads to extremely high mortality rate. Methods A library prescribed drugs was screened finding critical anti-tumor properties cells. The phosphoproteomics, kinase array, pulldown assay and drug affinity responsive target stabilization (DARTS) were applied...
UNC5 receptors are putative tumor suppressors whose expressions lost in some cancers, but the role of UNC5A during DNA damage bladder cancer remains undefined. To investigate into potential function cancer, we examined expression with real-time RT-PCR and Western blotting specimens analyzed effects chemotherapeutic drug on level knocking down drug-mediated cell death. In this current study, found low an effective induction by cisplatin lines wt p53, a significant reduction cisplatin-mediated...
Biological experiments performed in space crafts like stations, shuttles, and recoverable satellites has enabled extensive spaceflight life investigations (SLIs). In particular, SLIs have revealed distinguished effects on microbial growth, survival, metabolite production, biofilm formation, virulence development drug resistant mutations. These provide unique perspectives to ground-based microbiology new opportunities for industrial pharmaceutical productions. are with specialized...
Esophageal squamous cell carcinoma (ESCC) is an aggressive and deadly malignancy characterized by late-stage diagnosis, therapy resistance, a poor 5-year survival rate. Finding novel therapeutic targets their inhibitors for ESCC prevention urgently needed.
Objective. To investigate the efficacy of butylphthalide combined with edaravone in treatment acute ischemic stroke and effect on serum inflammatory factors. Methods. One hundred sixty patients who attended neurovascular intervention department our hospital from May 2020 to June 2022 were enrolled as study subjects for prospective analysis equally divided into a control group an experimental using random number table method, 80 cases each group. The was treated injection, while edaravone....
Objective: To observe and analyze the efficacy of recombinant tissue-plasminogen activator (rt-PA) thrombolysis combined with Solitaire AB stent mechanical thrombectomy in patients acute ischemic stroke.
To explore the effect of acute thrombolytic therapy combined with green channel on time and neurological function in stroke patients.A total 100 patients admitted to our hospital from August 2016 2019 were recruited as research cohort. In experimental group, 50 administered therapy, while control group general therapy. The times, muscle strength grades, FMA scores, Barthel index levels, NIHSS SSS SAS SDS arterial pressure heart rates, effective incidences postoperative adverse reactions,...