A5103042080- Selenium in Biological Systems
- Trace Elements in Health
- Mycotoxins in Agriculture and Food
- Heavy Metal Exposure and Toxicity
- Congenital heart defects research
- Animal Nutrition and Physiology
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Cardiac electrophysiology and arrhythmias
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Ferroptosis and cancer prognosis
- Cardiac Fibrosis and Remodeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience and Neural Engineering
- Vitamin C and Antioxidants Research
- Educational Reforms and Innovations
- Engineering Education and Curriculum Development
- Microbial infections and disease research
- Nanoplatforms for cancer theranostics
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
Renmin Hospital of Wuhan University
2019-2025
Xinxiang Medical University
2025
Zhongda Hospital Southeast University
2020-2024
Southwest Minzu University
2020-2024
China University of Geosciences
2024
Peking University
2024
Peking University Cancer Hospital
2024
Beijing University of Chemical Technology
2023-2024
Wuhan University
2019-2023
Fudan University
2022
Chronic hard-to-heal wounds draw great attention worldwide, as their treatments are limited by infections and hypoxia. Inspired the natural oxygen production capacity of algae competitive advantage beneficial bacteria over other microbes, we presented a living microecological hydrogel (LMH) with functionalized Chlorella Bacillus subtilis encapsulation to realize continuous delivery anti-infections for promoting chronic wound healing. As consisted thermosensitive Pluronic F-127 wet-adhesive...
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data showed the promising antitumor activity of afatinib EGFR-overexpressing ESCC. This proof-of-concept, phase II trial assessed efficacy and safety pretreated metastatic ESCC patients (n = 41) with EGFR overexpression (NCT03940976). The study met its primary endpoint, a confirmed objective...
The aim of this study was to investigate the possible protective role sodium selenite on aflatoxin B1-induced oxidative stress and apoptosis in spleen broilers. Two hundred one-day-old male broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB1 (AFB1 + 0.2 Se (+Se group I), 0.4 II) 0.6 III), respectively. According biochemical assays, significantly decreased activities glutathione peroxidase, total superoxide dismutase, reductase, catalase level hormone,...
The purpose of the present study was to investigate oxidative damage and apoptosis induced by aflatoxin B 1 (AFB ) in spleen broilers. A total 200 one-day-old avian male broilers were randomly divided into 4 equal groups 50 each fed for 21 days as follows: a control diet three AFB diets containing 0.15, 0.3, 0.6 mg /kg diet. Consumption stress chicken evidenced reduced glutathione peroxidase, reductase, catalase activities, decreased contents, increased malondialdehyde contents explaining...
Hepatic oxidative stress, as one important mechanism of cadmium (Cd)-induced hepatic toxicity, could, known, be ameliorated by vitamin E (VE). However, the underlying remains to elucidated. To investigate whether antioxidant can protect against Cd-induced sub-chronic liver injury associated with stress and nuclear factor erythrocyte 2-related 2 (Nrf2) pathway, male Sprague-Dawley rats (nine-week-old) were randomly divided into four groups (eight rats/group), namely, control, VE (100 mg/kg...
Mesenchymal stem cells (MSCs), which exert regulatory effects on various immune cells, have been a promising therapy for inflammatory bowel disease treatment. However, their therapeutic are limited by lack of nutritional supply, system attack, and low accumulation the target site. Here, inspired natural incubation mechanism roe, we present immune-isolating, wet-adhesive, nutrient-rich microcapsules MSCs encapsulation. The adhesive shells were fabricated ionic cross-linking alginate visible...
Responsive hydrogel microfibers can realize multiple controllable changes in shapes or properties under the stimulation of surrounding environment, and are called as intelligent biomaterials. Recently, these responsive have been proved to possess significant biomedical values, remarkable progress has achieved engineering applications, including drug delivery, biosensors clinical therapy, etc. In this review, latest research application prospects summarized. We first introduce common...
To explore AFB1-induced damage of the small intestine, changes in structure and expression TLRs (Toll-like Receptors) intestine chickens were systematically investigated. Ninety healthy neonatal Cobb randomized into a control group (0 mg/kg AFB1) an AFB1 (0.6 AFB1). The crypt depth was significantly increased comparison to chickens, while villus height area evidently decreased, as well villus:crypt ratio epithelial thickness. histopathological observations showed that villi exposed obviously...
Fungal infections are everlasting health challenges all over the world, bringing about great financial and medical burdens. Here, inspired by natural competition law of beneficial bacteria against other microbes, we present novel living microneedles (LMNs) with functionalized encapsulation for efficient fungal infection treatment. The chosen bacterial components, Bacillus subtilis (B. subtilis), which naturally found on human skin widely used food processing, can get nutrients from escape...
Background Immune checkpoint inhibitors (ICIs) have significantly improved patient survival in multiple cancers. However, therapy response esophageal cancer is limited to subgroups of patients and clinically useful predictive biomarkers are lacking. Methods We collected a series plasma samples from 91 with before after ICI treatment. The Olink Immuno-Oncology panel (92 proteins) proximity extension assays was used detect the dynamic changes potential associated treatment outcomes. screened...
As an extensively environmental pollution, Nickel (Ni) represents a serious hazard to human health. The present study focused on exploring the mechanism of Ni-mediated nephrotoxicity, such as apoptosis, autophagy and oxidative stress. In current work, NiCl
Cardiotoxicity linked to doxorubicin (DOX) is primarily caused by inflammation, oxidative stress, and apoptosis. The role of tubeimoside I (TBM) in DOX-induced cardiotoxicity remains ambiguous, despite growing evidence that it could reduce apoptosis various diseases. This study was designed investigate the TBM uncover underlying mechanisms. H9c2 cell line C57BL/6 mice were used construct an vitro vivo model myocardial injury, respectively. We observed DOX treatment provoked cardiomyocyte...
Electric heating technology is critical for aerospace de‐icing systems due to its efficiency and controllability. However, traditional electric elements such as resistance wires metal coatings have low thermal conductivity, poor high‐temperature resistance, insufficient structural flexibility, which severely limit their application in composites. This study introduces carbon nanotube (CNT)/nanocellulose fiber (CNF) composite films a solution. CNTs, with exceptional stability, mechanical...