A5009366443- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Phytochemical and Pharmacological Studies
- Hepatitis C virus research
- Medicinal plant effects and applications
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Lung Cancer Research Studies
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Uterine Myomas and Treatments
- Cardiac Arrest and Resuscitation
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Botanical Studies and Applications
- Medical Research and Treatments
- Liver physiology and pathology
- Streptococcal Infections and Treatments
- Seaweed-derived Bioactive Compounds
- Nanoparticle-Based Drug Delivery
- Food Industry and Aquatic Biology
- Drug-Induced Hepatotoxicity and Protection
- Polysaccharides and Plant Cell Walls
The People's Hospital of Guangxi Zhuang Autonomous Region
2021-2025
First Affiliated Hospital Zhejiang University
2024
Yale University
2020-2024
Gansu Agricultural University
2021-2023
Jiangnan University
2023
Wuxi People's Hospital
2013-2023
XinHua Hospital
2022
Shanghai Jiao Tong University
2022
Wuxi Fourth People's Hospital
2015-2021
Obstetrics and Gynecology Hospital of Fudan University
2014-2020
Context: Pathogen evolution currently outpaces novel drug development, and because development of new antibiotics is pending, combination therapy with existing drugs may provide effective alternative treatments.
Abstract Background Acute kidney injury (AKI) is a prevalent and severe complication of sepsis contributing to high morbidity mortality among critically ill patients. In this retrospective study, we develop novel risk-predicted nomogram associated-AKI (SA-AKI). Methods A total 2,871 patients from the Medical Information Mart for Intensive Care III (MIMIC-III) critical care database were randomly assigned primary (2,012 patients) validation (859 cohorts. SA-AKI was developed through...
This study aimed to construct and assess a machine-learning algorithm designed forecast survival rates risk stratification for patients with gastric neuroendocrine neoplasms (gNENs) after diagnosis. Data on gNENs were extracted randomly divided into training validation sets using the Surveillance, Epidemiology, End Results database. We developed prediction model 10 machine learning algorithms across 101 combinations cancer-related mortality in gNENs, selecting best highest mean over sequence...
Objective Developing and validating a simple clinically useful dynamic nomogram for predicting early acute kidney injury (AKI) in patients with heart failure (AHF) admitted to the intensive care unit (ICU). Methods Clinical data from AHF were obtained Medical Information Mart Intensive Care IV database. The randomly allocated into derivation validation sets. independent predictors AKI development identified through least absolute shrinkage selection operator multivariate logistic regression...
Iron and zinc deficiencies affect human health globally, especially in developing countries. Agronomic biofortification, as a strategy for alleviating these issues, has been focused on small-scale field studies, not widely applied while lacking of cost-effectiveness analysis (CEA).We conducted the CEA agronomic expressed USD per disability-adjusted life years (DALYs) saved, to recommend that can be applied.The DALYs were quantify burden due Fe and/or Zn deficiency cost biofortification via...
The lymphatic system plays crucial roles in maintaining fluid balance and immune regulation. Studying the liver lymphatics has been considered challenging, as common endothelial cell (LyEC) markers are expressed by other cells. Additionally, isolation of sufficient numbers LyECs challenging because their extremely low abundance (<0.01% entire population) a normal liver.
Phenolic ingredients of Hippophae tibetana (Tib) and H. rhamnoides ssp. sinensis (Rha) berry from Qinghai-Tibet Plateau were identified by Ultra Performance Liquid Chromatography-triple Quadrupole Tandem Mass Spectrometry. Results demonstrated that both them possessed high levels total phenolic flavonoid, compared to Tib, Rha exhibited higher contents. Moreover, flavonols was the most predominant subclass in berry, flavanols two abundant subclasses Tib berry. Among them, rutin narcissin...
Alcohol has been demonstrated to disrupt intestinal barrier integrity. Some flavonoid compounds that exert antioxidant activity have a protective effect on function. As an important medicinal and edible plant, sea buckthorn (Hippophae) seeds are rich in flavonoids, but their the not reported. In our research, 76 kinds of flavonoids were identified Hippophae rhamnoides ssp. sinensis seed residue (HRSF) by ultra-performance liquid chromatography-tandem mass spectrometry....
ObjectivesTo assess off-treatment virological relapse rates and to determine the role of hepatitis B surface antigen (HBsAg) quantification in predicting after stopping entecavir (ETV) treatment patients with e (HBeAg)-positive chronic (CHB).MethodsOne hundred twelve CHB for whom ETV was stopped accordance Asian Pacific Association Study Liver guidelines rules were enrolled. Patient HBsAg HBV DNA levels monitored every 4–12 weeks during cessation. Post-treatment defined as a serum level >10...
Objective Patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) are characterized by severe function impairment, coagulation disorder, and multiple organ impairment. The aim of this study was to explore the predictive value antithrombin Ⅲ activity prognosis HBV-ACLF patients. Methods A total 186 patients were included in analysis, baseline clinical data recorded analyze risk factors affecting 30-day survival outcome Bacterial infection, sepsis, hepatic...
Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology. A number questions regarding its etiology are unclear. CD4+CD25+ regulatory T cells (Tregs) play critical role in self-tolerance and, for unknown reasons, their relative reduced PBC patients. B-cell-activating factor (BAFF) key survival during B-cell maturation concentration increased peripheral blood It has been reported that activated B inhibit Treg cell proliferation there...
The Qinghai-Tibet Plateau is the main production area of Hippophae rhamnoides ssp. sinensis (Rha) and H. tibetana (Tib), but studies on types contents soluble sugars, organic acids, free phenolics, bound vitamin C (VC), tocopherol (VE) carotenoids two sea buckthorn berries from this region have not been reported. In paper, we found that sugars in Rha Tib were mainly glucose fructose; exhibited a higher content total sugar fructose compared to Tib. acids quinic acid malic acid; acid, lower...
Suillus granulatus is an edible and medicinal fungus in China. S. polysaccharide (SGP) was considered as the main bioactivity compounds granulatus. Therefore, extraction of SGP their antioxidant activities were studied this work.Fruiting bodies purchased from a local market (Fushun, China). Response surface methodology adopted to optimize conditions SGP. The immunological vitro also assayed.The optimized by Box-Behnken design. optimal for polysaccharides follows: Pre-extraction time, 2 h;...
Abstract Background The purpose of this study was to assess the efficacy and safety cisplatin-based chemotherapy with or without bevacizumab (BEV) in Chinese women advanced cervical cancer (ACC). Methods For observational study, we analysed data 316 ACC who were treated at Henan provincial people’s hospital between Jan 1, 2014, Dec 31, 2018, plus BEV (CB) alone (CA) until disease progression, unacceptable toxicity, death. co-primary endpoints overall survival (OS) progression-free (PFS);...
To investigate the association between interleukin-21 (IL-21) expression level and virological relapse (VR) of HBeAg positive chronic hepatitis B (CHB) after discontinuance entecavir (ETV).The serum IL-21 112 CHB patients was measured at 0, 12, 24, 52, 104 weeks ETV discontinuance. ELISA used for measurement level. VR defined as two continuous examinations with an interval 1 month both showing HBV DNA >10 000 copies/mL drug discontinuance.The levels were significantly higher in durable...
Background Over the past decades, incidence and prevalence of pancreatic neuroendocrine neoplasms (pNENs) have steadily increased. However, accurate prediction prognosis treatment this condition are currently challenging. This study aims to develop validate a personalized nomogram predict survival patients with pNENs.Materials methods A total 9739 pNENs were downloaded from Surveillance, Epidemiology, End Results (SEER) database. Subsequently, randomly assigned derivation cohort (n = 6874)...