A5039287818- Inflammasome and immune disorders
- Obstructive Sleep Apnea Research
- Cancer-related molecular mechanisms research
- Microbial Inactivation Methods
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D Printing in Biomedical Research
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Fungal Infections and Studies
- Breast Cancer Treatment Studies
- Brain Tumor Detection and Classification
- Cell death mechanisms and regulation
- Erythrocyte Function and Pathophysiology
- Thyroid Disorders and Treatments
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Alcohol Consumption and Health Effects
- Immune Response and Inflammation
- RNA modifications and cancer
- Bioactive Natural Diterpenoids Research
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
Second Military Medical University
2024
Changhai Hospital
2024
Huazhong University of Science and Technology
2017-2022
Tongji Hospital
2017-2022
Zhejiang University
2005
Sir Run Run Shaw Hospital
2005
Abstract Background Neutrophilic airway inflammation is a challenge in asthma management and associated with poor patient prognosis. Mucin 1 (MUC1), which contains cytoplasmic tail (MUC1-CT), has been found to mediate glucocorticoid sensitivity asthma; however, its role modulating neutrophilic remains unknown. Methods Human-induced sputum cells were collected from healthy participants (n = 12), patients mild-to-moderate 34), those severe 18). In vitro human lung bronchial epithelial cell...
MUC1 (mucin 1), a membrane-tethered mucin glycoprotein, is highly expressed on the surface of respiratory epithelial cells and plays key role in anti-inflammatory antiapoptotic responses against infections. However, little known about link between necroptosis asthma. This study aimed to investigate effects TNF-α-induced human bronchial (16HBE) underlying molecular mechanism. Negative control MUC1-siRNA were treated with TNF-α presence or absence necrostatin-1 (Nec-1). Necroptosis was...
Whether the clinical features of cryptococcal meningitis (CM) patients vary with coexistence pulmonary nodules is not clear. This study aimed to compare CM in and without detected by chest computed tomography (CT). The medical records hospitalized Tongji Hospital, Medical College, Huazhong University Science Technology from January 1, 2010, December 31, 2016, were retrospectively reviewed. Baseline demographics, laboratory radiographic findings, managements, outcomes analyzed. A total 90...
To investigate whether mucin 1 (MUC1) downregulation reduced the sensitivity of tumor necrosis factor-alpha (TNF-α)-induced bronchial epithelial cells to glucocorticoid-mediated necroptosis and explore underlying mechanisms. The human lung cell line (16HBE) was transfected with small interfering RNA (siRNA) against MUC1 then stimulated by TNF-α, where some were pretreated dexamethasone. Flow cytometry performed analyze in 16HBE cells, western blot analysis used detect protein expression...
Lung cancer is one of the main types due to its persistently high incidence and mortality, yet a simple effective prognostic model still lacking. This study aimed identify independent genes related heterogeneity lung adenocarcinoma (LUAD), generate risk score model, construct nomogram in combination with other pathological characteristics predict patients’ overall survival (OS). A significant amount data pertaining single-cell RNA sequencing (scRNA-seq), (RNA-seq), somatic mutation were used...
Background: De novo metastasis of breast cancer is a complex clinical issue to be identified. This study was the first construct artificial neural networks (ANN) and logistic regression (LR) models with comparison find out important factors associated occurrence de in invasive cancer. Methods: A total 40,899 patients diagnosed metastatic 2010 from Surveillance, Epidemiology End Results (SEER) Cancer database were enrolled. ANN LR constructed based on thirteen relevant by 10-fold...
Abstract α5β1 integrin is highly expressed in airway smooth muscle cells and mediate the adhesion of to fibronectin regulate remodelling asthma. This study aimed investigate effects synthetic cyclic peptide * CRRETAWAC on fibronectin‐induced cytokine secretion underlying mechanism. Human were isolated treated with fibronectin, IL ‐13, peptide, integrin‐blocking antibody, FAK inhibitor or p38 MAPK inhibitor. The transcription eotaxin‐1 RANTES detected by real‐time PCR ELISA , respectively....
The most common interventional therapies for liver cancer at present include transcatheter hepatic arterial chemoembolization (TACE),1 percutaneous ethanol injection2 and radiofrequency ablation,3 but all these have some intrinsic disadvantages. Since the advent of electrochemotherapy (EChT), it has been accepted as a safe effective therapy malignant tumors4,5 There are only few experimental studies reporting use EChT in treatment foreign medical literature.6–8 However, there clinical...
Abstract Lung adenocarcinoma (LUAD) was one of the most important subtypes lung cancer, which had attracted much attention due to its high morbidity and mortality in tumors for a long time. Although threat LUAD human health been reduced continuous upgrading innovative medical methods, 5-year survival rate less than quarter. There growing need better understand molecular mechanisms that influence development LUAD. Using bioinformatics we identified 95 genes were significantly upregulated...