A5103121513- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Long-Term Effects of COVID-19
- Cancer, Hypoxia, and Metabolism
- Enzyme Production and Characterization
- Dermatology and Skin Diseases
- Genomics and Phylogenetic Studies
- Lung Cancer Treatments and Mutations
- Protein Hydrolysis and Bioactive Peptides
- Fibroblast Growth Factor Research
- Molecular Sensors and Ion Detection
- Microbial Community Ecology and Physiology
- Osteoarthritis Treatment and Mechanisms
- Luminescence and Fluorescent Materials
- Metal complexes synthesis and properties
- Quinazolinone synthesis and applications
- Advanced Electron Microscopy Techniques and Applications
Huazhong Agricultural University
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
Army Medical University
2018-2024
Daping Hospital
2018-2024
Huazhong University of Science and Technology
2021-2022
Tongji Hospital
2020-2022
South China Normal University
2016
Psoriasis Association
2004
Stanford University
2004
BACKGROUND. Fatal cases of COVID-19 are increasing globally. We retrospectively investigated the potential immunologic parameters as early predictors COVID-19.
The dynamic interplay between tyrosine kinase inhibitors (TKIs) and the tumor immune microenvironment (TME) plays a crucial role in therapeutic trajectory of non-small cell lung cancer (NSCLC). Understanding functional dynamics resistance mechanisms TKIs is essential for advancing treatment NSCLC.
<title>Abstract</title> In this work, an easy prepared solid fluorescent sensor 3-(benzo[d]thiazol-2-yl)-1-hydroxy-4-oxo-3,4-dihydrophthalazine-6-carboxylic acid (<bold>BPCA</bold>) was designed and synthesized the structure proved by IR, UV-Vis, NMR, HRMS elemental analysis, which displayed high selectivity sensitivity for fluorescence colormetric from green to blue sensing 1, 4-dioxane in water, detection limit obtained 0.009% stability constant 7.4×10<sup>4</sup> M. Also,...
The emergence of antibiotic-resistant bacteria has attracted interest in the field endolysins. Here, we analyzed diversity Streptococcus endolysins and identified a new endolysin, Ply2741, that exhibited broad-spectrum bactericidal activity. Our results demonstrated Ply2741 could effectively eradicate multidrug-resistant gram-positive pathogens vitro vivo. Structural analysis revealed activity depends on classic "Cys-His-Asn" catalytic triad. Site-directed mutagenesis further conserved...
Lung cancer is one of the main types due to its persistently high incidence and mortality, yet a simple effective prognostic model still lacking. This study aimed identify independent genes related heterogeneity lung adenocarcinoma (LUAD), generate risk score model, construct nomogram in combination with other pathological characteristics predict patients’ overall survival (OS). A significant amount data pertaining single-cell RNA sequencing (scRNA-seq), (RNA-seq), somatic mutation were used...
Abstract Lung adenocarcinoma (LUAD) was one of the most important subtypes lung cancer, which had attracted much attention due to its high morbidity and mortality in tumors for a long time. Although threat LUAD human health been reduced continuous upgrading innovative medical methods, 5-year survival rate less than quarter. There growing need better understand molecular mechanisms that influence development LUAD. Using bioinformatics we identified 95 genes were significantly upregulated...