A5101710941- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infections and Vectors
- Plant Disease Resistance and Genetics
- Probiotics and Fermented Foods
- Vector-Borne Animal Diseases
- interferon and immune responses
- Plant-Microbe Interactions and Immunity
- Mosquito-borne diseases and control
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Plant and Fungal Interactions Research
- Salmonella and Campylobacter epidemiology
- Rice Cultivation and Yield Improvement
- Herpesvirus Infections and Treatments
- GABA and Rice Research
- Gut microbiota and health
- Plant Virus Research Studies
- Plant Pathogenic Bacteria Studies
- Microbial infections and disease research
- Escherichia coli research studies
Center of Hubei Cooperative Innovation for Emissions Trading System
2018-2025
Huazhong Agricultural University
2016-2025
BGI Group (China)
2024
China Medical University
2024
BGI Research
2024
Ministry of Agriculture and Rural Affairs
2023
Nanchang University
2017-2022
Ministry of Science and Technology of the People's Republic of China
2020-2022
State Key Laboratory of Food Science and Technology
2022
Xiangya Hospital Central South University
2010-2021
ABSTRACT Seneca Valley virus (SVV) is an oncolytic RNA belonging to the Picornaviridae family. Its nucleotide sequence highly similar those of members Cardiovirus genus. SVV also a neuroendocrine cancer-selective picornavirus that can be used for anticancer therapy. However, interaction between and its host yet fully characterized. In this study, inhibited antiviral type I interferon (IFN) responses by targeting different adaptors, including mitochondrial signaling (MAVS), Toll/interleukin 1...
Macroautophagy/autophagy plays a critical role in antiviral immunity through targeting viruses and initiating host immune responses. The receptor protein, SQSTM1/p62 (sequestosome 1), vital selective autophagy. It serves as ubiquitinated proteins or pathogens to phagophores for degradation. In this study, we explored the reciprocal regulation between autophagy SQSTM1 Seneca Valley virus (SVV). SVV infection induced Autophagy promoted pig cells but played opposite functions human cells....
Abstract ‘Minghui 63’ is a restorer line widely used in hybrid rice production China for the last two decades. This and its derived hybrids, including ‘Shanyou 63’, are susceptible to bacterial blight (BB), caused by Xanthomonas oryzae pv. ( Xoo ). To improve resistance of rice, genes Xa21 Xa7 , have been introgressed into marker‐assisted selection conventional backcrossing, respectively. The single gene‐introgressed lines, Minghui 63 ) had higher levels than their Shanyou or Both showed...
Abstract Crown rot caused by Fusarium pseudograminearum (teleomorph: Gibberella coronicola ) is a serious disease of wheat. A simple and reliable method for assessing this would enhance our capacity in identifying resistance sources developing resistant wheat cultivars. In searching such method, several inoculation techniques were tested. One technique, soaking 1‐ to 4‐day old seedlings fungal spore suspension, produced consistent severe crown symptoms. Glasshouse testing genotypes using...
Foot-and-mouth disease (FMD) is a highly contagious of domestic and wild ruminants that caused by FMD virus (FMDV). outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which flavonoid naturally existing plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant antiviral activities. Results show apigenin can inhibit FMDV-mediated cytopathogenic effect FMDV replication vitro. Further studies demonstrate the following: (i)...
Seneca valley virus (SVV), a member of the Picornaviridae family, is small non-enveloped RNA virus, that linked to porcine idiopathic vesicular disease (PIVD). SVV infection in swine results and epidemic transient neonatal losses (ETNL). The first case was reported Guangdong, South China 2015. We isolated characterized an HB-CH-2016 strain from lesion tissue specimens piglets with PIVD Hubei, Central China. complete genome sequence shares high nucleotide identities (94 99 %) all previously...
Abstract The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role host antiviral function. TRIM proteins exert their activity either directly by degrading viral through E3 ligase activity, or indirectly promoting innate immunity. This study demonstrated for the first time that TRIM52 is a novel against Japanese encephalitis virus (JEV) infection. Overexpression restricted JEV replication BHK-21 293T cells. In addition,...
The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage therapy. Phage cocktails have been considered one approach to mitigate this issue. However, the synergistic effect randomly selected phages in ambiguous. Here, we rationally designed cocktail consisting four that utilize lipopolysaccharide (LPS) O antigen, LPS outer core, inner and membrane proteins BtuB TolC on Salmonella enterica serovar Enteritidis cell surface as receptors. We demonstrated four-phage...
The transcription factor NF-κB plays an important role in modulation of inflammatory pathways, which are associated with diseases, neurodegeneration, apoptosis, immune responses, and cancer. Increasing evidence indicates that TRIM proteins crucial the regulation signaling pathways. In this study, we identified TRIM67 as a negative regulator TNFα-triggered activation. Ectopic expression significantly represses TNFα-induced activation pro-inflammatory cytokines TNFα IL-6. contrast, Trim67...
Seneca Valley virus (SVV) is the only member of genus Senecavirus Picornaviridae family. SVV can selectively infect and lyse tumor cells with neuroendocrine features used as an oncolytic for treating small-cell lung cancers. However, detailed mechanism underlying SVV-mediated destruction remains unclear. In this study, we found that increase proportion apoptotic 293T in a dose- time-dependent manner. SVV-induced apoptosis was initiated via extrinsic intrinsic pathways through activation...
Shiga toxin-producing
Seneca Valley virus (SVV), a newly emerging belonging to the Picornaviridae family, has caused vesicular disease in swine industry. However, molecular mechanism of viral pathogenesis remains poorly understood. This study revealed that SVV infection could induce pyroptosis SK6 cells caspase-dependent and -independent manner. may inhibit caspase-1 activation at late because 3Cpro cleavage NLRP3, which counteracted activation. Further showed targeted porcine gasdermin D (pGSDMD) for through its...
The emergence of antibiotic-resistant bacteria has attracted interest in the field endolysins. Here, we analyzed diversity Streptococcus endolysins and identified a new endolysin, Ply2741, that exhibited broad-spectrum bactericidal activity. Our results demonstrated Ply2741 could effectively eradicate multidrug-resistant gram-positive pathogens vitro vivo. Structural analysis revealed activity depends on classic "Cys-His-Asn" catalytic triad. Site-directed mutagenesis further conserved...
Abstract Sow endometritis is usually caused by multiple species of pathogenic bacteria. Numerous isolates from patients have developed antimicrobial resistance. Thus, novel antibacterial agents and strategies to combat are needed. A total 526 bacteria, including Staphylococcus spp. (26.3%), Streptococcus (12.3%), E. coli (28.9%), Enterococcus (20.1%), Proteus (9.5%), Corynebacterium (2.8%), were isolated sows with endometritis. We constructed a chimeric lysin, ClyL, which composed cysteine-...
Introduction Streptococcus suis , an important zoonotic and opportunistic pathogen in pigs, brings huge economic losses to the pig-raising industry infects humans with diseases. Phage lysin is regarded as a promising substitute for antibiotics due its ability quickly efficiently kill bacteria without easily developing resistance. However, their clinical applications have been hindered by inherent instability under environmental stressors. Methods We constructed B. subtilis spores displaying...