A5073637619- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Molecular Sensors and Ion Detection
- Plant tissue culture and regeneration
- Synthesis and Biological Evaluation
- Axial and Atropisomeric Chirality Synthesis
- Catalytic Processes in Materials Science
- Chemical synthesis and alkaloids
- Supercapacitor Materials and Fabrication
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Metal-Organic Frameworks: Synthesis and Applications
- Polymer Nanocomposites and Properties
- Chemical Synthesis and Reactions
- Spectroscopy and Quantum Chemical Studies
- Cancer, Hypoxia, and Metabolism
- Synthesis of Indole Derivatives
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Advanced Synthetic Organic Chemistry
- Conducting polymers and applications
- Peptidase Inhibition and Analysis
Sichuan University of Science and Engineering
2018-2025
University of Alabama
2025
Peking University
2007-2024
Nanjing University of Chinese Medicine
2020-2024
Northwest A&F University
2021-2024
Ningxia Medical University
2024
Norwegian Institute of Bioeconomy Research
2024
Second Affiliated Hospital of Jilin University
2024
Tokyo University of Agriculture and Technology
2022
Institute of Process Engineering
2022
It′s just a phase: The title reaction sequence of para-quinone methides (p-QMs) has been developed with malonates under phase-transfer catalysis. also offers an alternative route to asymmetric construction diarylmethine stereocenters in excellent enantioselectivities and high yields. As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset....
Small molecules that can selectively target cancer stem cells (CSCs) remain rare currently and exhibit no common structural features. Here we report a series of guaianolide sesquiterpene lactones (GSLs) their derivatives eradicate acute myelogenous leukemia (AML) or progenitor cells. Natural GSL compounds arglabin, an anticancer clinical drug, micheliolide (MCL), are able to reduce the proportion AML (CD34⁺CD38⁻) in primary Targeting is further confirmed by sharp reduction colony-forming...
Spheres-like coordination polymer architectures in submicro regimes have been synthesized from the hydrothermal reaction of transition metal ions and 3,5-bis(pyridin-3-ylmethylamino)benzoic acid (L1). The size final was dependent on concentrations reactants. Scanning electron microscopy studies monitored at numerous stages growth reveal that coordination-induced morphology changes uncoordinated flowerlike ligands to sphere-like particles. Moreover, variations luminescent antibacterial...
A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric β,β-diaryl-α-amino acid esters via 1,6-conjugate addition para-quinone methides glycine derivatives is described. This protocol also provides an alternative route to synthetically interesting functionalized chiral tetrahydroisoquinoline its analogues.
Cisplatin, cis-[Pt(Cl2(NH3)2], can crosslink residues His67 of domain I and His247 II in human albumin, occupying the major binding site for essential metal zinc on protein.
A new strategy focusing on the last-stage asymmetric assembly of ring D, which inherently possesses densest part stereogenic centers and functional groups in A/B/C/D system (-)-cephalotaxine, has been developed, a novel Rh-catalyzed (2 + 3) annulation tertiary enamides with enoldiazoacetates is designed explored for enantioselective construction crucial cyclopentane D bearing unique spirocyclic aza-quaternary stereocenter. Based expeditious access chiral functionalized building block...
Interactions of organometallic ruthenium anticancer complexes [Ru(eta6-arene)Cl(en)][PF6] (arene=p-cymene (1) or biphenyl (2), en=ethylenediamine) with human serum albumin were investigated by means mass spectrometry combined trypsin digestion, specific sidechain modifications and computational modelling. Both shown to bind surface histidine (His128, His247, His510) methionine (Met298) residues in albumin, but only the p-cymene complex can gain entry crevice containing free cysteine thiolate...
The genome stability is maintained by coordinated action of DNA repairs and checkpoints, which delay progression through the cell cycle in response to damage. Rad9 conserved from yeast human functions checkpoint controls. Here, a regulatory mechanism for function reported. In this study has been found interact with be methylated protein arginine methyltransferase 5 (PRMT5). Arginine methylation plays critical role S/M G2/M checkpoints. activation downstream effector Chk1 impaired cells only...
Günstige Phase: Die Titelreaktionssequenz von para-Chinonmethiden (p-QMs) und Malonaten unter Phasentransferkatalyse bietet eine Alternative für die hoch enantioselektive Einführung Diarylmethin-Stereozentren; Produkte werden in hohen Ausbeuten erhalten. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues...
Novel (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides were designed synthesized as new analogues of 1, which showed interesting multifunctional neuroprotective effects, including antioxidative antineuroinflammatory properties. Specifically, target compounds display excellent potency in scavenging reactive free radicals demonstrate potent effects against various kinds toxicities, H2O2, 6-hydroxydopamine, lipopolysaccharide different types neuronal cells. The properties the are more...
An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for detecting Cu2+ was synthesized and used fluorescence imaging in HeLa cells. The specifically localized lysosomes successfully applied to visualize as well monitor level changes the of living
Abstract The skeleton of tropane alkaloids is derived from ornithine-derived N -methylpyrrolinium and two malonyl-CoA units. enzymatic mechanism that connects units remains unknown. Here, we report the characterization three pyrrolidine ketide synthases (PYKS), Aa PYKS, Ds Ab different hyoscyamine- scopolamine-producing plants. By examining crystal structure biochemical activity show reaction involves PYKS-mediated condensation to generate a 3-oxo-glutaric acid intermediate can undergo...
Purpose Silicon-containing groups were introduced into fluoroacrylate polymer to further improve the comprehensive performance of pressure-sensitive adhesive (PSA) for expanded polytetrafluoroethylene (ePTFE) bonding. Design/methodology/approach A series silicon-containing fluorinated acrylic copolymers synthesized through free radical solution polymerization with vinyloxy trimethylsilane, allyltrimethylsilane, 3-(trimethoxysilyl)propyl methacrylate or 1,3,5-tris(3,3,3-trifluoropropyl)...
Abstract Injecting nerve‐blocking agents near peripheral nerves is a clinical option for treating post‐operative and chronic pain. However, the nerve barriers (PNBs) pose physiological barrier that hinders permeation of through PNBs, ultimately affecting their efficacy on neurons. Here, glucose‐modified nanomicelles (Glu‐NMs) are developed self‐assembled from glucose‐functionalized 3‐aminophenylboronic acid‐ polyethylene glycol‐ stearic acid polymer (GLU‐PBA‐PEG‐SA) Pluronic P 123 . It...
Carbon-coated Mn3O4 nanowires (Mn3O4@C NWs) have been synthesized by the reduction of well-shaped carbon-coated bixbyite networks and characterized TEM, X-ray diffraction, photoelectron spectroscopy, electrochemical experiments. To assess properties 1D for their use in supercapacitors, cyclic voltammetry galvanostatic charging-discharging measurements were performed. @C NWs could be charged discharged faster had higher capacitance than bare nanostructures other commercial materials. The...
A Zn2+ tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.
Temperature-dependent and uniform NiO/Co<sub>3</sub>O<sub>4</sub>composites have been presented, which show high specific capacitances good cycling performances even at current densities.