A5103664955- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Quinazolinone synthesis and applications
- Synthesis of heterocyclic compounds
- Chemical Synthesis and Analysis
- Synthesis and Reactions of Organic Compounds
- Sulfur-Based Synthesis Techniques
- HIV Research and Treatment
- Porphyrin Metabolism and Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Complexity and Algorithms in Graphs
- Click Chemistry and Applications
- Organic Chemistry Cycloaddition Reactions
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Free Radicals and Antioxidants
- Carbohydrate Chemistry and Synthesis
- Hepatitis C virus research
Wuhan University
2024-2025
Peking University
2014-2023
Tongji Hospital
2023
Tongji University
2023
Shenzhen University
2023
Horological Research Institute of Light Industry
2011
University of Minnesota System
1999
Beijing Hospital of Traditional Chinese Medicine
1999
Novel (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides were designed synthesized as new analogues of 1, which showed interesting multifunctional neuroprotective effects, including antioxidative antineuroinflammatory properties. Specifically, target compounds display excellent potency in scavenging reactive free radicals demonstrate potent effects against various kinds toxicities, H2O2, 6-hydroxydopamine, lipopolysaccharide different types neuronal cells. The properties the are more...
Novel 6-substituted-4-cycloalkyloxy-pyridin-2(1H)-ones were synthesized as non-nucleoside reverse transcriptase inhibitors (NNRTIs), and their biological activity was evaluated. Most of the compounds, especially 26 22, bearing a 3-isopropyl 3-iodine group, respectively, exhibited highly potent against wild-type HIV-1 strains those resistant to (RTIs). The diastereoisomers 26-trans 26-cis separately confirmed with HPLC NOESY spectra. isomers had an about 400-fold more than that 26-cis. pair...
Reward design is a key component of deep reinforcement learning, yet some tasks and designer's objectives may be unnatural to define as scalar cost function. Among the various techniques, formal methods integrated with DRL have garnered considerable attention due their expressiveness flexibility reward requirements for different states actions agent. However, how leverage Signal Temporal Logic (STL) guide multi-agent learning remains unexplored. Complex interactions, heterogeneous goals...
A novel series of 2-arylalkylthio-5-iodine-6-substitutedbenzyl-pyrimidine-4(3H)-ones (S-DABOs) 8a-x had been synthesized via an efficient method. Their biological activity against HIV virus and RT assay were evaluated. Some compounds, especially 8h, 8l 8n, displayed promising HIV-1 with IC50 values in a range 0.41 μM to 0.71 μM, which much better than that nevirapine. Molecular modeling studies revealed the binding mode would be affected forming additional hydrogen bond by incorporating...
Background Human adipose tissue-derived stem cells (hADSCs) exert potent immunosuppressive effects in the allogeneic transplantation treatment. In mouse model of allergic rhinitis (AR), ADSCs partially ameliorated AR. However, no study has evaluated potential therapeutic hADSC-derived extracellular vesicles (hADSC-EVs) on Methods Female BALB/c mice were sensitized and challenged with ovalbumin (OVA) to induce One day after last nasal drop, each group received phosphate buffered saline (PBS)...
Main observation and conclusion An efficient method for the activation of C ‐terminal 4‐mecaptoproline‐ or penicillamine‐containing peptide hydrazides in ligation reactions is reported herein. The corresponding can be readily prepared using solid‐phase synthesis, subsequently activated by acetylacetone (acac) without exogenous thiol additives. Strained peptidyl thiolactones could possible reactive intermediates that drastically accelerate reaction rates at sterically demanding proline valine...
(E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides have been reported as novel multifunctional neuroprotective agents in previous studies, which phenolic compounds display antioxidative antineuroinflammatory properties. To further enhance the effects study structure-activity relationship of derivatives, we synthesized their acetylated (E)-3,4-diacetoxystyryl sulfoxides, examined vitro models Parkinson’s disease. The results indicate that can significantly inhibit kinds neuron cell...