A5100396495- S100 Proteins and Annexins
- Antibiotic Resistance in Bacteria
- Ferroelectric and Negative Capacitance Devices
- Semiconductor materials and devices
- RNA Research and Splicing
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Tuberculosis Research and Epidemiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- MXene and MAX Phase Materials
- Molecular Biology Techniques and Applications
- Plant tissue culture and regeneration
- Polyamine Metabolism and Applications
- Cancer Cells and Metastasis
- Integrated Circuits and Semiconductor Failure Analysis
- RNA regulation and disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Computational Drug Discovery Methods
- Advancements in Semiconductor Devices and Circuit Design
- 2D Materials and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Sensor Technologies Research
Minhang District Central Hospital
2025
Fudan University
2025
Huazhong University of Science and Technology
2006-2024
State Key Laboratory of Advanced Electromagnetic Engineering and Technology
2024
Ministry of Education of the People's Republic of China
2016-2023
Northwest University
2021-2023
Shimane University
2023
Shandong Jiaotong University
2023
Huazhong Agricultural University
2021
Affiliated Hospital of Qingdao University
2020
Abstract Previous data have suggested that the nuclear translocation of annexin 1 (ANXA1) is involved in neuronal apoptosis after ischemic stroke. As mechanism and function ANXA1 migration remain unclear, it important to clarify how performs its role as an ‘regulator’ nucleus. Here we report importazole (IPZ), importin β (Imp )-specific inhibitor, decreased accumulation reduced rate death induced by oxygen-glucose deprivation–reoxygenation (OGD/R). Notably, interacted with Bid...
Epithelial cell adhesion molecule (EpCAM) and glypican-3 (GPC3) are associated with a poor survival rate in hepatocellular carcinoma (HCC). Predicting aggressive HCC non-invasively should be investigated using preoperative gadoxetic acid-enhanced MRI clinical characteristics. This retrospective study examined 134 patients confirmed cases of who had undergone gadolinic before surgery. The data were collected between November 2017 December 2021. Significant parameters subjected to quantitative...
Annexin A1 (ANXA1) is a protein known to have multiple roles in the regulation of inflammatory responses. In this study, we find that after oxygen glucose deprivation/reoxygenation (ODG/R) injury, activated PKC phosphorylated ANXA1 at serine 27 residue (p27S-ANXA1), and promoted translocation p27S-ANXA1 nucleus BV-2 microglial cells. This turn induced cells produce large amounts pro-inflammatory cytokines. The phenomenon could be mimicked by either transfecting mutant form with its converted...
Abstract Background Mitochondrial dysfunction caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA, which codes for components, are known to be associated with various genetic and congenital disorders. These disorders not only impair energy production but also affect functions have no effective treatment. Mesenchymal stem cells (MSCs) migrate damaged sites carry out transfer. MSCs grown using conventional culture methods exhibit heterogeneous cellular characteristics. In contrast,...
Annexin-1 (ANXA1) has shown neuroprotective effects and microglia play significant roles during central nervous system injury, yet the underlying mechanisms remain unclear. This study sought to determine whether ANXA1 regulates microglial response oxygen–glucose deprivation/reperfusion (OGD/R) treatment clarify downstream molecular mechanism. In rat hippocampal slices, OGD/R enhanced expression in neuron, formyl peptide receptor (FPRs) microglia, activation CA1 region (cornu ammonis 1)....
Annexin A1 (ANXA1) is an endogenous protein with potent anti-inflammatory properties in the brain. Although ANXA1 has been predominantly studied for its binding to formyl peptide receptors (FPRs) on plasma membranes, little known regarding whether this effect cytosol. Here, we investigated mechanism by which Ac2-26 decreases high TNF-α production and IKKβ activity, was caused oxygen glucose deprivation/reperfusion (OGD/R)-induced neuronal conditioned medium (NCM) microglia. We found that...
In insects, glutathione S-transferases (GSTs) are multifunctional enzymes playing an important role in metabolizing a wide range of endogenous and exogenous compounds, including plant secondary insecticides, odorant molecules. this study, we identified 14 GSTs from codling moth Cydia pomonella (L.), which is worldwide internal pest tree fruit. The cytosolic contain the conserved (GSH)-binding domain substrate-binding domain. microsomal transmembrane proteins containing motif consisting 16...
Brassica napus is an important oilseed crop that offers a considerable amount of biomass for global vegetable oil production. The establishment efficient genetic transformation system with convenient transgenic-positive screening method great importance gene functional analysis and molecular breeding. However, to our knowledge, there are few the aforementioned systems available application in B. napus.Based on well-established napus, five vectors carrying red fluorescence protein encoding...
The continuous emergence of multi-drug resistant pathogens co-expressing serine and metallo-carbapenemases seriously threatens the efficacy carbapenem. Here, we report first SeCN-derived dual inhibitor with IC50 values ranging from 0.0038 to 1.27 μg mL-1. was shown form covalent bonds Cys221 NDM-1 Ser70 KPC-2, respectively, achieving selective labelling cross-class inhibition for carbapenemases. Our results provide a potential strategy develop clinically useful inhibitors targeting combat superbugs.
The formation of biogenic amines (BAs) are important potential risks in Suan yu. This study investigated the amine production abilities 97 strains enteric bacteria screened from genotypic diversity amino acid decarboxylase and effect pH were explored on 27 high-yield BAs. Results showed that high levels putrescine, histamine, cadaverine produced by strains. In addition, carried odc, speA, speB, adiA, ldc genes. 13 hdc gene. Morganella morganii strain 42C2 highest putrescine content 880 mg/L...
Background: This study aimed to investigate the effects of matrine (MAT) on drug resistance K562/ADM cells.
Previous studies showed that the yellow seed color gene of a mustard was located on A09 chromosome. In this study, sequences molecular markers linked to were analyzed, primarily mapped an interval 23.304 29.402M. Twenty genes and eight markers' in region selected design IP SCAR primers. These primers used screen BC8S1 population consisting 1256 individuals. As result, five successfully developed. IP4 Y1 either side at distance 0.1 0.3 cM, respectively. IP1, IP2 IP3 derived from Bra036827,...
Abstract Bacterial resistance caused by metallo‐β‐lactamases (MβLs) has become an emerging public health threat, and the development of MβLs inhibitor is effective way to overcome resistance. In this study, thirteen novel O ‐aryloxycarbonyl hydroxamates were constructed assayed against MβLs. The obtained molecules specifically inhibited imipenemase‐1 (IMP‐1) New Delhi metallo‐β‐lactamase‐1, exhibiting IC 50 value in range 0.10–18.42 0.23–22.33 μM, respectively. hydroxamate 5 was found be...