A5101747930- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Breast Cancer Treatment Studies
- Phytochemical Studies and Bioactivities
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Radical Photochemical Reactions
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Fluorine in Organic Chemistry
- NF-κB Signaling Pathways
- Lipid metabolism and biosynthesis
- Congenital heart defects research
- Galectins and Cancer Biology
- Phytochemicals and Antioxidant Activities
- RNA Research and Splicing
- Phytochemistry and Biological Activities
- Synthesis and Reactions of Organic Compounds
- Advanced Radiotherapy Techniques
- Soybean genetics and cultivation
Nanning Normal University
2025
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
Affiliated Hospital of Jining Medical University
2024
Fudan University Shanghai Cancer Center
2019-2024
Tongji Hospital
2019-2024
Huazhong University of Science and Technology
2024
Chinese Academy of Sciences
2012-2022
Institute of Biophysics
2016-2022
University of Chinese Academy of Sciences
2019-2022
Many long non-coding RNAs(lncRNAs) have been found to be a good marker for several tumors. Using lncRNA-mining approach, we aimed identify lncRNA expression signature that can predict breast cancer patient survival.We performed LncRNA profiling in 887 patients from Gene Expression Omnibus (GEO) datasets. The association between and clinical survival was analyzed using the training set(n = 327, GSE 20685). validation another three independent testing sets(252 GSE21653, 204 GSE12276, 104...
Soybean (Glycine max) production is severely affected in unfavorable environments. Identification of the regulatory factors conferring stress tolerance would facilitate soybean breeding. In this study, through coexpression network analysis salt-tolerant wild soybeans, together with molecular and genetic approaches, we revealed a previously unidentified function class B heat shock factor, HSFB2b, salt response. We showed that HSFB2b improves promotion flavonoid accumulation by activating one...
Soybean (Glycine max) is one of the most important oilseed crops. However, regulatory mechanism that governs process oil accumulation in soybean remains poorly understood. In this study, GmZF392, a tandem CCCH zinc finger (TZF) protein which was identified our previous RNA-seq analysis seed-preferred transcription factors, found to function as positive regulator lipid production. GmZF392 promotes seed both transgenic Arabidopsis and stable plants by binding bipartite cis-element, containing...
// Xin-Li Liu 1, * , Xu-Tao Zhang Jin Meng 2, 3, Hong-Fei 1 Yong Zhao 4 Chen Li Yang Sun Qi-Bing Mei Feng and Tao 2 Key Laboratory of Gastrointestinal Pharmacology Chinese Materia Medica the State Administration Traditional Medicine, Department Pharmacology, School Pharmacy, Fourth Military Medical University, Xi'an, China Thoracic Surgery, Tangdu Hospital, 3 Pharmcy, Hospital PLA, Beijing, Animal Center, These authors contributed equally to this work Correspondence to: Zhang, email:...
Abstract Emerging studies have shown that the aberrant expression and function of long non-coding RNAs (lncRNAs) are involved in carcinogenesis development various cancers. The noncoding RNA JPX (lncRNA JPX) on X chromosome is an activator X-inactive-specific transcript (XIST) a molecular switch for X-chromosome inactivation. However, exact mechanism by which acts non-small-cell lung cancer (NSCLC) not well studied. Here, through integrating clinical data series functional experiments, we...
In this study, a modular and efficient approach towards benzo[c]isothiazole 2-oxides via copper-catalyzed intramolecular C-N cross-coupling reaction was discosed. Readily available starting materials, broad substrate scope, outstanding yields the scalability were observed, highlighing its potential in pharmaceuticals chemical industries.
Background Alzheimer's disease (AD) is the fastest-growing neurodegenerative disorder globally, with patient numbers expected to rise 130 million by 2050. Insomnia, a prevalent comorbidity, exhibits bidirectional relationship AD: insomnia accelerates AD pathology, while worsens sleep disorders. This has emerged as key area of research. Current mechanisms involve oxidative stress, inflammatory responses, and glymphatic system dysfunction, yet comprehensive review these processes remains...
// Feng Zhang 1,* , Xutao Jin Meng 2,3,* Yong Zhao 4 Xinli Liu 1 Yanxia 5 Yukun Wang Yuhua Li Yang Sun Zhipeng Qibing Mei and Tao 6 Key Laboratory of Gastrointestinal Pharmacology Chinese Materia Medica the State Administration Traditional Medicine, Department Pharmacology, School Pharmacy, Fourth Military Medical University, Xi’an, China 2 Oncology, Tangdu Hospital, The 3 No. 309 Hospital PLA, Beijing, Animal Center, National Engineering Center for Biochip, Shanghai, Thoracic Surgery,...
Background ING5 is the last member of Inhibitor Growth (ING) candidate tumor suppressor family that has been implicated in multiple cellular functions, including cell cycle regulation, apoptosis, and chromatin remodeling. Our previous study showed overexpression inhibits lung cancer aggressiveness epithelial–mesenchymal transition (EMT), with unknown mechanisms. Methods Western blotting was used to detect total phosphorylated levels β‐catenin EMT‐related proteins. Immunofluorescent staining...
Cancer cell migration is involved in tumour metastasis. However, the relationship between calcium signalling and cancer not well elucidated. In this study, we used human lung adenocarcinoma A549 line to examine role of endoplasmic reticulum protein 44 (ERP44), which has been reported regulate release inside (ER), migration. We found that inositol 1,4,5-trisphosphate receptors (IP3Rs/ITPRs) inhibitor 2-APB significantly inhibited by inhibiting polarization pseudopodium protrusion, suggests...
Increasing evidence has shown that long non-coding RNAs (lncRNAs) have important biological functions and can be used as a prognostic biomarker in human cancers. However, investigation of the value lncRNAs head neck squamous cell carcinoma (HNSCC) is infancy. In present study, we analyzed lncRNA expression data large number HNSCC patients (n=425) derived from The Cancer Genome Atlas (TCGA) to identify an signature for improving prognosis HNSCC. Three are identified significantly associated...
Abstract Background The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their mechanism pathogenesis hepatocellular carcinoma (HCC) remain explored. Methods CircRNA expression profiles tumor tissues plasma samples from HCC patients were compiled jointly analyzed. CircRNA–miRNA–mRNA interactions predicted by bioinformatics tools. interacting miRNAs mRNA was...
The hippocampus, with its complex subfields, is linked to numerous neuropsychiatric traits. While most research has focused on global structure or a few specific comprehensive analysis of hippocampal substructures and their genetic correlations across wide range traits remains underexplored. Given the hippocampus's high heritability, considering subfield volumes (HASV) as endophenotypes for conditions essential. We analyzed MRI-derived volumetric data structures from 41,525 UK Biobank...
Increasing evidence has highlighted the involvement of imbalance long non-coding RNAs in development gastric cancer (GC), which is one most common malignancies world. This study aimed to determine role lncRNA WT1-AS progression GC and explore its underlying mechanism.
Metastasis is the main cause of mortality patients with cancer‑related disease. Targeting process metastasis has been proposed as a potential strategy in cancer treatment. Trillium tschonoskii Maxim., traditional Chinese medicine, used for treatment numerous diseases, including cancer. The current study aimed to determine anti‑metastatic effect Paris saponin VII (PS Ⅶ), which was extracted from T. using SW620 and LoVo cells, two human metastatic colorectal (CRC) cell lines. present conducted...
Nuclear factor-kappa B (NF-κB) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (CRC). The aim of this study was evaluate the chemopreventive efficacy apple polysaccharide extract (AP) inhibiting NF-κB-mediated inflammation pathways CRC. We evaluated AP vitro HT-29 and SW620 human CRC cells. also used azoxymethane dextran sodium sulphate (AOM/DSS) model induce colon carcinogenesis vivo. chemoprotective effects were assessed using Western blot,...