A5100427908- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Plant and Fungal Species Descriptions
- Herpesvirus Infections and Treatments
- Autophagy in Disease and Therapy
- Virology and Viral Diseases
- Endoplasmic Reticulum Stress and Disease
- Intraocular Surgery and Lenses
- Animal Disease Management and Epidemiology
- Poxvirus research and outbreaks
- Cancer Research and Treatments
- Animal Virus Infections Studies
- Genetic diversity and population structure
- Mosquito-borne diseases and control
- Inflammatory Bowel Disease
- Ocular Disorders and Treatments
- Fullerene Chemistry and Applications
- Developmental Biology and Gene Regulation
- Plant Gene Expression Analysis
- Birth, Development, and Health
- Venomous Animal Envenomation and Studies
- Plant Ecology and Taxonomy Studies
- Genetic and rare skin diseases.
Chinese Academy of Sciences
2015-2025
Dalian Institute of Chemical Physics
2025
Jiangxi Agricultural University
2023-2024
Washington University in St. Louis
2024
Northwest A&F University
2020-2024
University of Chinese Academy of Sciences
2015-2023
Institute of Genetics and Developmental Biology
2023
Shanghai Institute of Materia Medica
2019-2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Xi'an Jiaotong University
2023
We have determined the complete chloroplast (cp) genome sequence of Cephalotaxus oliveri. The is 134,337 bp in length, encodes 113 genes, and lacks inverted repeat (IR) regions. Genome-wide mutational dynamics been investigated through comparative analysis cp genomes C. oliveri wilsoniana. Gene order transformation analyses indicate that when distinct isomers are considered as alternative structures for ancestral cupressophyte Pinaceae lineages, it not possible to distinguish between...
Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death a receptor-interacting protein 3 (RIPK3)-dependent manner. Recently, it increasingly noted that RIPK3 intrinsically silenced hepatocytes, raising question about the role hepatocellular carcinoma (HCC). This study reports previously unrecognized regulating parthanatos, programmed distinct from necroptosis. In HCC cells with intrinsic...
Abstract More than 190 plastid genomes have been completely sequenced during the past two decades due to advances in DNA sequencing technologies. Based on this unprecedented abundance of data, extensive genomic changes revealed genomes. Inversion is most common mechanism that leads gene order changes. Several inversion events recognized as informative phylogenetic markers, such a 30-kb found all living vascular plants minus lycopsids and short inversions putatively shared by ferns. Gene loss...
Due to unprecedented epidemics of Zika virus (ZIKV) across the Americas and unexpected clinical symptoms, including Guillain-Barré syndrome, microcephaly, other birth defects in humans, there is an urgent need for ZIKV vaccine development. Here we provided first attenuated versions with two important genes (E and/or NS1) that were subjected codon pair deoptimization. Compared parental ZIKV, pair-deoptimized ZIKVs mammal preferred insect mammalian cells. Min E+NS1, most restrictive variant,...
On the basis of synergism topoisomerase (Top) and histone deacetylase (HDAC) inhibitors in antitumor therapy, a series novel Top/HDAC dual were designed synthesized by pharmacophore fusion strategy. After systematic structure–activity relationship studies, lead compound 16j was identified to simultaneously inhibit both Top HDAC with good potency, which showed potent antiproliferative activities broad spectrum. Mechanistic studies indicated that efficiently induced apoptosis S cell-cycle...
Stress-induced proline accumulation in plants is thought to result primarily from enhanced biosynthesis and decreased degradation. To identify regulatory components involved transport, we screened for Arabidopsis thaliana T-DNA mutants with tolerance toxic levels of exogenous (45 mM). We isolated the resistant 1-1 (pre1-1) mutant map-based cloning identified PRE1 as AMINO ACID PERMEASE1 (AAP1, At1g58360), which encodes a plasma membrane-localized amino acid permease. AAP1 expression induced...
<title>Abstract</title> FH<sup>deficient</sup> renal cell carcinoma (RCC) is a highly metastatic and challenging malignancy. Here, we show that the aberrant accumulation of intracellular disulfides in cells leads to actin cytoskeleton contraction induces caspase-independent form death. However, inhibition Rho-associated coiled-coil containing protein kinase (ROCK) (which regulates contraction) suppresses Under glucose starvation, attempt mitigate NADPH consumption by downregulating reductive...
Human SULT2A1 is one of two predominant sulfotransferases in liver and catalyzes transfer the sulfuryl moiety (-SO(3)) from activated sulfate (PAPS, 3'-phosphoadenosine 5-phosphosulfate) to hundreds acceptors (metabolites xenobiotics). Sulfation recodes biologic activity by altering their receptor interactions. The molecular basis on which these enzymes select sulfonate specific complex mixtures competitors vivo a long-standing issue SULT field. Raloxifene, synthetic steroid used prevention...
Monkeypox virus (MPXV) is a cross-kingdom pathogen infecting both humans and wildlife, which poses significant health risk to the public. Although MPXV attracts broad attention, there lack of adequate studies elucidate pathogenic mechanisms associated with viral infections. In this study, high-throughput RNA sequencing (RNA-seq) liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach was used explore transcriptional metabolic responses A23 protein HEK293T cells. The...
Abstract Epidermal growth factor receptor (EGFR) is a member of the tyrosine kinases ErbB family and it found to be overexpressed in gastric cancer. However, mechanism regulation EGFR expression still unknown. We used Sequenom EpiTYPER assay detect methylation status promoter normal tumour tissues 30 patients with also carried out quantitative real time PCR (qPCR) level our patients. Notably, increased at was than corresponding adjacent noncancerous. In both Region I DMR II detected study,...
Abstract Hepatitis-hydropericardium syndrome (HHS) induced by fowl adenovirus serotype-4 (FAdV-4) has caused large economic losses to the world poultry industry in recent years. HHS is characterized pericardial effusion and hepatitis, manifesting as a swollen liver with focal necroses petechial haemorrhage. However, process of FAdV-4 entry into hepatic cells remains largely unknown. In this paper, we present comprehensive study on mechanism leghorn male hepatocellular (LMH) cells. We first...
The tumour suppressor ARF (alternative reading frame) is one of the most important oncogenic stress sensors. provides an ‘oncogenic checkpoint’ function through both p53-dependent and p53-independent mechanisms. In present study, we demonstrate a novel interaction between p14ARF adenovirus oncoprotein E1A. inhibits E1A transcriptional promotes ubiquitination-dependent degradation overexpression relocalizes into nucleolus E1A-induced cellular DNA replication independent p53. Knockdown...
Hydropericardium-hepatitis syndrome (HHS) is caused by some strains of fowl adenovirus serotype 4 (FAdV-4). However, the mechanism FAdV-4 entry not well understood. Therefore, to investigate changes in host cellular response at early stage infection, a conjoint analysis miRNA-seq and mRNA-seq was utilized with leghorn male hepatocellular (LMH) cells 30, 60, 120 min after infection. In total, we identified 785 differentially expressed (DE) miRNAs 725 DE mRNAs FAdV-4-infected LMH cells. Most...
Abstract Background DNA methylation has been viewed as the most highly characterized epigenetic mark for genome regulation and development. Postnatal brains appear to exhibit stimulus-induced changes because of factors such environment, lifestyle, diet (nutrition). The purpose this study was examine how extensively brain methylome is regulated by nutrition in early life. Results By quantifying total amount 5-methylcytosine (5mC) thalamus hippocampus postnatal malnourished mice normal mice,...
The complete chloroplast genome sequence of Amentotaxus argotaenia was determined in this study. is 136 657 bp length and lacks one inverted repeat region. overall GC content the 35.85% (protein-coding genes, 36.90%; tRNA 53.31%; rRNA 52.99%; introns, 36.10%; intergenic spacers, 31.03%). A. contains 118 unique including 83 protein-coding 31 four genes. Ten genes six have intron, while ycf3 two. coding regions occupy 60.27% gene density estimated to be 0.88 genes/kb. A maximum likelihood...
• Premise of the study: Microsatellite loci were developed for Cephalotaxus oliveri , an endemic and endangered conifer in China, which will allow assessment levels genetic diversity a means to understand consequences habitat fragmentation. Methods Results: Using Fast Isolation by AFLP Sequences COntaining (FIASCO) Repeats protocol, 19 microsatellite identified C. 13 polymorphic within sample 52 individuals representing five natural populations. The actual number alleles per locus ranged...