A5090967945- Topic Modeling
- Mental Health via Writing
- Sentiment Analysis and Opinion Mining
- Advanced Fluorescence Microscopy Techniques
- Biomedical Text Mining and Ontologies
- Text and Document Classification Technologies
- Natural Language Processing Techniques
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cellular transport and secretion
- RNA Research and Splicing
- Intimate Partner and Family Violence
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Metal complexes synthesis and properties
- Acoustic Wave Resonator Technologies
- Microplastics and Plastic Pollution
- Health disparities and outcomes
- Cell Image Analysis Techniques
- Cellular Mechanics and Interactions
- Plant Molecular Biology Research
- Advanced oxidation water treatment
- Microbial Fuel Cells and Bioremediation
- Muscle Physiology and Disorders
Chinese Academy of Sciences
2014-2025
Emory University
2020-2025
Tianjin Institute of Industrial Biotechnology
2025
Tianjin University of Science and Technology
2010-2025
Peoples' Friendship University of Russia
2024-2025
Shanxi Medical University
2025
Zhejiang Sci-Tech University
2025
Sichuan Agricultural University
2024-2025
Rice Research Institute
2024-2025
Sun Yat-sen University
2024-2025
Abstract Endosomes are compositionally dynamic organelles that regulate signaling, nutrient status and organelle quality by specifying whether material entering the cells will be shuttled back to cell surface or degraded lysosome. Recently, membrane contact sites (MCSs) between endoplasmic reticulum (ER) endosomes have emerged as important players in endosomal protein sorting, dynamics motility. Here, we show PDZD8, a Synaptotagmin-like Mitochondrial lipid-binding Proteins (SMP)...
Abstract A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation nucleoids are thought be passively determined by fusion division. Here we provide evidence, using live-cell super-resolution imaging, that can actively transported via KIF5B-driven dynamic tubulation (MDT) activities predominantly occur at ER-mitochondria contact sites (EMCS). We further demonstrate a inner membrane protein complex MICOS links...
Abstract Quantifying small, rapidly progressing three-dimensional forces generated by cells remains a major challenge towards more complete understanding of mechanobiology. Traction force microscopy is one the most broadly applied probing technologies but ascertaining information typically necessitates slow, multi-frame z-stack acquisition with limited sensitivity. Here, performing traction using fast single-frame astigmatic imaging coupled total internal reflection fluorescence we improve...
The aim of the Social Media Mining for Health Applications (#SMM4H) shared tasks is to take a community-driven approach address natural language processing and machine learning challenges inherent utilizing social media data health informatics. In this paper, we present annotated corpora, technical summary participants' systems, performance results.
Abstract Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological processes including organ morphogenesis angiogenesis. The mechanism governing accumulation migrasomes has been elusive. In this study, we show that secretory proteins, are transported into by carriers via both constitutive regulated secretion pathways. During cell migration,...
Lipid droplets (LDs) are critical for lipid storage and energy metabolism. LDs form in the endoplasmic reticulum (ER). However, molecular basis LD biogenesis remains elusive. Here, we show that fat storage–inducing transmembrane protein 2 (FIT2) interacts with ER tubule-forming proteins Rtn4 REEP5. The association is mainly domain based stimulated by oleic acid. Depletion of decreases number size cells Caenorhabditis elegans, mimicking loss FIT2. Through cytosolic loops, FIT2 binds to...
The abLIM1 is a nonerythroid actin-binding protein critical for stable plasma membrane–cortex interactions under mechanical tension. Its depletion by RNA interference results in sparse, poorly interconnected cortical actin networks and severe blebbing of migrating cells. isoforms, abLIM-L, abLIM-M, abLIM-S, contain, respectively four, three, no LIM domains, followed C terminus entirely homologous to erythroid cortex dematin. How functions, however, remains unclear. Here we show that...
Intimate partner violence (IPV) is a preventable public health problem that affects millions of people worldwide. Approximately one in four women are estimated to be or have been victims severe at some point their lives, irrespective age, ethnicity, and economic status. Victims often report IPV experiences on social media, automatic detection such reports via machine learning may enable improved surveillance targeted distribution support and/or interventions for those need. However, no...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measurements are essential to understanding the role biomechanics in cell regulation and function. Traction force microscopy remains most broadly applied probing technology but typically restricts itself single-plane two-dimensional quantifications with limited spatiotemporal resolution. Here, we introduce an enhanced measurement technique combining 3D super-resolution fluorescence structural...
Abstract Chronic diseases, because of insidious onset and long latent period, have become the major global disease burden. However, current chronic diagnosis methods based on genetic markers or imaging analysis are challenging to promote completely due high costs cannot reach universality popularization. This study analyzed massive data from routine blood biochemical test 32 448 patients developed a novel framework for cost-effective prediction with accuracy (AUC 87.32%). Based...
Abstract Objectives Large language models (LLMs) have demonstrated remarkable success in natural processing (NLP) tasks. This study aimed to evaluate their performances on social media-based health-related text classification Materials and Methods We benchmarked 1 Support Vector Machine (SVM), 3 supervised pretrained (PLMs), 2 LLMs-based classifiers across 6 developed approaches for leveraging LLMs: employing LLMs as zero-shot classifiers, using data annotators, utilizing with few-shot...
High plasma concentrations of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are associated with hepatic dysfunction in patients nonalcoholic fatty liver disease (NAFLD). However, it is unknown whether ADMA involved the pathogenesis NAFLD. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) enzyme that degrades ADMA. In this study, we used Ddah1-/- mice to investigate effects ADMA/DDAH1 pathway on high-fat diet (HFD)-induced steatosis.After HFD feeding for...