A5043676114- RNA Research and Splicing
- Cellular transport and secretion
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Silk-based biomaterials and applications
- Endoplasmic Reticulum Stress and Disease
- Acute Myeloid Leukemia Research
- Hemoglobin structure and function
- Genetics, Aging, and Longevity in Model Organisms
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Lipid Membrane Structure and Behavior
- Nuclear Structure and Function
Hadassah Medical Center
2022
Hebrew University of Jerusalem
2022
Weizmann Institute of Science
2017-2021
Genome duplication in eukaryotes created paralog pairs of ribosomal proteins (RPs) that show high sequence similarity/identity. However, individual paralogs can confer vastly different effects upon cellular processes, e.g., specific yeast regulate actin organization, bud site selection, and mRNA localization, although how specificity is conferred unknown. Changes the RP composition ribosomes might allow for specialized translation subsets mRNAs, yet it unclear whether exist if controls...
Abstract Endosomes are compositionally dynamic organelles that regulate signaling, nutrient status and organelle quality by specifying whether material entering the cells will be shuttled back to cell surface or degraded lysosome. Recently, membrane contact sites (MCSs) between endoplasmic reticulum (ER) endosomes have emerged as important players in endosomal protein sorting, dynamics motility. Here, we show PDZD8, a Synaptotagmin-like Mitochondrial lipid-binding Proteins (SMP)...
Myoblast fusion is essential for muscle development and regeneration. Yet, it remains poorly understood how mononucleated myoblasts fuse with preexisting fibers. We demonstrate that ERK1/2 inhibition (ERKi) induces robust differentiation of primary mouse through a linear pathway involving RXR, ryanodine receptors, calcium-dependent activation CaMKII in nascent myotubes. results myotube growth via at fusogenic synapse. Mechanistically, interacts regulates MYMK Rac1, CaMKIIδ/γ knockout mice...
AML cells are arranged in a hierarchy with stem/progenitor giving rise to more differentiated bulk cells. Despite the importance of stem/progenitors pathogenesis AML, determinants state not fully understood. Through comparison genes that significant for growth and viability by way CRISPR screen, differentially expressed leukemia stem (LSC), we identified importin 11 (IPO11) as novel target AML. Importin is member β family proteins mediate transport across nuclear membrane. In knockdown IPO11...