A5100707672- Neurotransmitter Receptor Influence on Behavior
- Virus-based gene therapy research
- Plant-based Medicinal Research
- Biochemical Analysis and Sensing Techniques
- Behavioral Health and Interventions
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Polysaccharides and Plant Cell Walls
- Genetic Associations and Epidemiology
- Vagus Nerve Stimulation Research
- NF-κB Signaling Pathways
- Photoacoustic and Ultrasonic Imaging
- Pharmacological Effects of Medicinal Plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Berberine and alkaloids research
- Mental Health Research Topics
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
Air Force Medical University
2005-2017
National Institute of Mental Health
2000
The serotonin transporter (5-HTT) regulates serotonergic neurotransmission and is thought to influence emotion. A 5-HTT-linked polymorphic region (5-HTTLPR) has two common variants, short (s) long (l). We previously found population within-family associations between the lower-expressing s allele neuroticism, a trait related anxiety, hostility, depression, on standard measure (the NEO Personality Inventory, Revised [NEO-PI-R]) in primarily male (n=505), that was dominant. investigated this...
The present study evaluated the singular and interactive effects of a functional polymorphism (variation) in serotonin transporter (5-HTT) gene psychological trait (anxiety sensitivity [AS], i.e., fear arousal symptoms) predicting subjective physiological responses to 35% carbon dioxide (CO2) challenge community sample (N = 72). Genotypes were divided into 2 groups accord with prior research. Findings partially supportive hypothesized risk model. These indicated that Group L genotype...
Oncolytic virus which arms the therapeutic gene to enhance anti-tumor activity is a prevalent strategy improve oncovirotherapy of cancer. Newcastle disease (NDV) naturally oncolytic used for cancer therapy. Previously, we generated mouse-human chimeric HAb18 antibody (cHAb18) against tumor-associated antigen CD147 and demonstrated inhibition invasion migration hepatocellular carcinoma (HCC) cells. Here, constructed recombinant NDV carrying intact cHAb18 (rNDV-18HL) based on Italien strain...
Nuclear factor-kappa B (NF-κB) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (CRC). The aim of this study was evaluate the chemopreventive efficacy apple polysaccharide extract (AP) inhibiting NF-κB-mediated inflammation pathways CRC. We evaluated AP vitro HT-29 and SW620 human CRC cells. also used azoxymethane dextran sodium sulphate (AOM/DSS) model induce colon carcinogenesis vivo. chemoprotective effects were assessed using Western blot,...
Although apoptosis plays an important role in the development of Diabetic Encephalopathy (DE), underlying molecular mechanisms remain unclear. With respect to this, present work aims study variation chloride/proton exchanger ClC-3 expression and its association with HT22 hippocampal neuronal under hyperglycemic condition vitro . The cells were stimulated added 0, 5, or 25 mM glucose mannitol for up 72 hours before assessing rate expression, cell viability, apoptosis. In a consecutive...