A5114375241- Radio Astronomy Observations and Technology
- Astrophysics and Cosmic Phenomena
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Galaxies: Formation, Evolution, Phenomena
- Pulsars and Gravitational Waves Research
- Astrophysical Phenomena and Observations
- Gamma-ray bursts and supernovae
- Cardiac Ischemia and Reperfusion
- Particle physics theoretical and experimental studies
- Nuclear physics research studies
- Neutrino Physics Research
- Quantum Chromodynamics and Particle Interactions
- Earthquake Detection and Analysis
- Computational Physics and Python Applications
- Neuroscience and Neural Engineering
- Protein Kinase Regulation and GTPase Signaling
- Genetics, Aging, and Longevity in Model Organisms
- Anesthesia and Neurotoxicity Research
- CRISPR and Genetic Engineering
- Muscle Physiology and Disorders
- Aldose Reductase and Taurine
- Autophagy in Disease and Therapy
- Calpain Protease Function and Regulation
- Relativity and Gravitational Theory
China Three Gorges University
2024
Chinese Academy of Sciences
2010-2023
University of Chinese Academy of Sciences
2021-2023
Xinjiang Astronomical Observatory
2021-2023
Institute of Biophysics
2010-2017
Calstabin2 is a component of the cardiac ryanodine receptor (RyR2) macromolecular complex, which modulates Ca(2+) release from sarcoplasmic reticulum in cardiomyocytes. Previous reports implied that genetic deletion leads to phenotypes related aging. However, mechanistic role process aging remains unclear. To assess whether involved age-related heart dysfunction, we studied knockout (KO) and control wild-type (WT) mice. We found significant association between Indeed, aged KO mice exhibited...
Abstract Using nearly simultaneous radio, near-infrared, optical, and ultraviolet (UV) data collected since 2009, we constructed 106 spectral energy distributions (SEDs) of the blazar OJ 287. These SEDs are well fitted by a log-parabolic model. By classifying into “flare” “quiescent” segments, find that median flux at peak frequency during flare segments is 0.37 ± 0.22 dex higher compared to quiescent while no significant differences observed in values curvature parameter b or <mml:math...
Abstract We present the first multiband centimeter detection of POX 52, a nearby dwarf galaxy believed to harbor robust intermediate-mass black hole. conducted deep observations using Australia Telescope Compact Array (ATCA), spanning frequencies from 4.5 10 GHz, as well sensitive Karl G. Jansky Very Large (VLA) operating in its most extended A configuration at S band (2–4 GHz) and C (4–8 GHz). In ATCA observations, source shows compact morphology, with only one direction marginally...
Abstract A black hole (BH) can tear apart a star that ventures within its tidal radius, producing luminous flare as the stellar debris falls back, known disruption event (TDE). While TDEs in quiescent galaxies are relatively well understood, identifying active galactic nuclei (AGNs) still remains significant challenge. We present discovery of AT2021aeuk, transient exhibiting dual flares around 3 yr narrow-line Seyfert 1 galaxy. Multiwavelength observations triggered during second 2023...
Cancer cell migration is involved in tumour metastasis. However, the relationship between calcium signalling and cancer not well elucidated. In this study, we used human lung adenocarcinoma A549 line to examine role of endoplasmic reticulum protein 44 (ERP44), which has been reported regulate release inside (ER), migration. We found that inositol 1,4,5-trisphosphate receptors (IP3Rs/ITPRs) inhibitor 2-APB significantly inhibited by inhibiting polarization pseudopodium protrusion, suggests...
We perform correlation and periodicity search analyses on long-term multi-band light curves of the FSRQ 1510-089 observed by space-based Fermi--Large Area Telescope in gamma-rays, SMARTS Steward Observatory telescopes optical near-infrared (NIR) 13.7 m radio telescope Metsahovi Radio between 2008 2018. The z-transform discrete function method is applied to study possible time lags among these multi band curves. Among all pairs wavelengths, gamma-ray vs. optical/NIR NIR correlations show zero...
Abstract RNA binding protein is identified as an important mediator of aberrant alternative splicing in muscle atrophy. The altered calcium channels, such ryanodine receptors (RyRs), plays role impaired excitation-contraction (E-C) coupling atrophy; however, the regulatory mechanisms receptor 1 (RyR1) leading to skeletal atrophy remains be investigated. In this study we demonstrated that CUG (CUG-BP1) was up-regulated and RyR1 ASI (exon70) during process neurogenic both human patients mouse...
Abstract Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, which an intracellular calcium channel and abundant in the brain. Previous studies identified role leaky neuronal RyR2 posttraumatic stress disorder (PTSD). However, functional Calstabin2 cognitive function remains unclear. Herein, we used mouse model genetic deletion to investigate dysfunction. We found that knockout (KO) mice showed...
The heart contraction is controlled by the Ca2+-induced Ca2+ release (CICR) between L-type channels and ryanodine receptors (RyRs). FK506-binding protein FKBP12.6 binds to RyR subunits, but its role in stabilizing function has been debated for long. Recent reports of high-resolution structure show that HD2 domain SPRY2 neighbouring subunit FKBP-bound RyR1 detached invisible FKBP-null RyR2. present study was test consequence absence on situ activation RyR2.Using whole-cell patch-clamp...
Abstract To investigate the short-term variability and determine size of optical continuum emitting region intermediate-mass black holes (IMBHs), we carried out high-cadence, multiband photometric monitoring a Seyfert 1 galaxy J0249−0815 across two nights, together with one-night single-band preliminary test. The presence broad H α component in our target was confirmed by recent Palomar/P200 spectroscopic observations, 23 yr after Sloan Digital Sky Survey, ruling supernovae origin line....
Cardiomyocytes derived from murine embryonic stem (ES) cells possess various membrane currents and signaling cascades link to that of hearts. The role atrial natriuretic peptide (ANP) in regulation potentials Ca(2+) has not been investigated developmental cardiomyocytes.We the ANP regulating L-type channel current (I(CaL)) different stages cardiomyocytes ES cells. decreased frequency action (APs) early stage (EDS) cardiomyocytes, bodies (EB) as well whole embryo exerted an inhibitory effect...
We present the first multi-band centimeter detection of POX 52, a nearby dwarf galaxy believed to habor robust intermediate mass black hole (IMBH). conducted deep observations using Australia Telescope Compact Array (ATCA), spanning frequencies from 4.5 10 GHz, as well sensitive Karl G. Jansky Very Large (VLA) operating in its most extended A-configuration at S band (2--4 GHz) and C (4--8 GHz). In ATCA observations, source shows compact morphology, with only one direction marginally...
Using nearly simultaneous radio, near-infrared, optical, and ultraviolet data collected since 2009, we constructed 106 spectral energy distributions (SEDs) of the blazar OJ 287. These SEDs were well-fitted by a log-parabolic model. By classifying into `flare' `quiescent' segments, found that median flux at peak frequency during flare segments was 0.37$\pm$0.22 dex higher compared to quiescent while no significant differences observed in values curvature parameter $b$ or $\log...
We studied the relation of accretion-jet power and disk luminosity, especially jet efficiencies radiative for different accretion disks as well black hole (BH) spin, in order to explore origin radio emission X-ray binaries (BHXBs). found that efficiency increases more rapidly (efficient) than nearly constant thin component high regime, which could account steep track ($\mu>1$) observed luminosity relations ($L_{\rm R}\propto L_{\rm X}^{\mu}$), but may not be able explain standard...
由于手征有效场论核力、量子多体关联方法和超级计算机能力的发展，原子核第一性原理计算或称从头计算(ab initio, first principles)在最近20年取得了巨大的进步. 作为处理强关联多体问题的新秀，介质相似重整化群理论（in-medium similarity renormalization group, 简称IMSRG）已经在原子核第一性原理计算中发挥重要作用. 虽然理论本身仍需进一步发展，但目前的计算已经可以达到较重核区，如已经成功地实现了对<sup>208</sup>Pb的收敛计算. 本文将简要回顾介质相似重整化群理论的发展历史，介绍作者在介质相似重整化群理论方面的最新发展，即：复动量空间介质相似重整化群和形变介质相似重整化群. 复空间介质相似重整化群方法包含了连续谱耦合作用，可以描述原子核的非束缚共振态和弱束缚特性. 形变相似重整化群可以更有效地描述形变原子核的结构.
Abstract High resolution imaging of inner jets in Active Galactic Nuclei (AGNs) with Very Long Baseline Interferometry (VLBI) at millimeter wavelengths provides deep insight into the launching and collimation mechanisms relativistic jets. The BL Lac object, PKS 1749+096, shows a core-dominated jet pointing toward northeast on parsec-scales revealed by various VLBI observations. In order to investigate kinematics, particular, orientation smallest accessible scales basic physical conditions...
The magnetic field performance of the uniform coils will be affected by shields and produce errors in atomic magnetometer. It is necessary to analyze influencing factors guide coil design. In this paper, model under ferromagnetic boundary built influence size, thickness permeability shield on magnitude uniformity Lee-Whiting coil. And improved combining linearly decreasing inertia weight particle swarm algorithm. results show that coupling coefficient changes monotonically with change size...
We collected the archival data of blazar OJ~287 from heterogeneous very long baseline interferometry (VLBI) monitoring programs at 2.3 GHz, 8.6 15 GHz and 43 GHz. The reduction observable extraction those multi-band multi-epoch observations are batch-processed consistently with our automated pipeline. present multivariate correlation analysis on observables each band. employ cross-correlation function to search correlations Monte Carlo (MC) technique verify certainty correlations. Several...