A5074940051- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Microstructure and mechanical properties
- Aluminum Alloys Composites Properties
- Animal Virus Infections Studies
- Aluminum Alloy Microstructure Properties
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Bacillus and Francisella bacterial research
- Extracellular vesicles in disease
- Surface Treatment and Residual Stress
- Fatigue and fracture mechanics
- MicroRNA in disease regulation
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Neuroscience and Neural Engineering
- Immunotherapy and Immune Responses
- interferon and immune responses
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Supramolecular Self-Assembly in Materials
- Metal Forming Simulation Techniques
- Microstructure and Mechanical Properties of Steels
University of Science and Technology of China
2022-2025
Chinese Academy of Sciences
2010-2024
Wuhan University of Technology
2024
Institute of Microbiology
2021-2023
Zhongda Hospital Southeast University
2022-2023
Southeast University
2022
Institute of Zoology
2014
Institute of Biophysics
2010
Abstract Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some linked to an increase in case numbers globally. However, there is yet a lack understanding the molecular basis for interactions between human ACE2 (hACE2) receptor these VOCs. Here we examined several VOCs including Alpha, Beta, Gamma, demonstrate that five receptor-binding domain (RBD) increased binding affinity hACE2, four pseudoviruses entry into susceptible cells. Crystal structures hACE2-RBD complexes...
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging mutations on spike's properties, we performed systematic structural analyses apo spike and its complexes with human ACE2 or S309 neutralizing antibody (NAb) by cryo-EM. The preferentially adopts one-RBD-up conformation both before after binding, which in sharp contrast to orchestrated conformational changes create more up-RBDs upon binding as observed prototype other four variants concern (VOCs)....
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal (mAbs), covering seven identified epitope classes RBD, against sub-variants BA.1, BA.1.1, BA.2, BA.3. Binding pseudovirus-based neutralizing assays revealed that 37 mAbs lost activities, whereas others displayed variably decreased activities four sub-variants. BA.2 was found be more sensitive RBD-5 than other Furthermore, a...
This investigation delves into the intricacies of process mechanism for generating a gradient nanostructured surface (GNS) layer on M50 bearing steel, with aim augmenting its hardness and wear resistance under elevated temperature. The electron backscatter diffraction transmission microscopy substantiate successful formation GNS layer, surpassing 200 µm in thickness, steel treated by Ultrasonic shot peening (USP) technology. severe plastic deformation (SPD) induced USP resulted significant...
The Omicron variant of SARS-CoV-2 carries multiple unusual mutations, particularly in the receptor-binding domain (RBD) spike (S) protein. Moreover, host-adapting such as residues 493, 498, and 501, were also observed RBD, which indicates that it is necessary to evaluate interspecies transmission risk variant. Herein, we evaluated recognition BA.1 Delta RBDs by 27 ACE2 orthologs, including humans. We found expanded its receptor binding spectra palm-civet, rodents, more bats (least horseshoe...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted between humans and minks, some mutations in the spike (S) protein, especially receptor-binding domain (RBD), have been identified mink-derived viruses. Here, we examined binding of mink angiotensin-converting enzyme (ACE2) receptor to important human-originating variants, demonstrated that most RBD variants increased affinities ACE2 (mkACE2). Cryo-electron microscopy structures mkACE2-RBD Y453F (with a Y-to-F change...
<title>Abstract</title> Phototropism is ubiquitous in plants that endows them directional movement and substantial growth toward light sources. Simultaneous replication of such phototropic volumetric synthetic polymers important but currently remains challenging. Here, we report the molecular design a photoswitchable tricyanofuran (TCF) based hydrogel can concurrently display self-growth water under stimulation pH. The macroscale hdyrogel originates directly from charge rise TCF switch upon...
The improvement of strength in the heterostructures consisting ultrafine structures and coarse grains is generally achieved by tailoring volume fraction structures, but this comes at expense ductility. In work, we succeeded maintaining heterostructured Cu while their domain sizes. Interestingly, reducing size from ~38 μm to ~20 increases yield ~40% without sacrificing any uniform elongation. synergy ductility results additional hetero-interfaces induced smaller domains, which could...
Since the identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), etiological agent COVID-19, multiple SARS-CoV-2-related viruses have been characterized, including pangolin-origin GD/1/2019 and GX/P2V/2017. Our previous study indicated that both potential to infect humans. Here, we find CB6 (commercial name etesevimab), a COVID-19 therapeutic monoclonal antibody (MAb) developed by our group, efficiently inhibits but not A total 50 SARS-CoV-2 MAbs divided into seven...
Deformation and subsequent annealing are often combined to optimize the overall mechanical properties of metallic materials. In this work, strength-ductility trade-off between dynamic plastic deformation (DPD)-induced annealed DPD structures in Cu Cu-4.5Al alloy was compared. The combination samples is inferior that samples, while synergy comparable for which reasons were analyzed based on tensile mechanism these samples. This work suggested high performance materials can be obtained by just...
With the wide distribution of vaccines against COVID-19, we are witnessing gradually waning neutralizing antibodies and cases breakthrough infections. This necessitate development drugs aside from vaccines, particularly ones that can be administered outside hospitals. Here, present two cross-reactive nanobodies, R14 S43, maintain potent activities SARS-CoV-2 after aerosolization, show cross-reactivity multiple variants, including latest Omicron, several sarbecoviruses. Through intranasal...
SUMMARYSARS-CoV-2 Omicron variant has brought huge challenges to current antibodies and vaccines. Herein, we systematically compared 50 human monoclonal (MAbs), covering seven identified epitope classes of the SARS-CoV-2 RBD, for their efficacy against Omicron, including BA.1, BA.1.1, BA.2 BA.3. Majority MAbs (36 out 50) completely lost neutralizing activities, while others displayed variably decreased activities four sub-variants. Notably, found is more sensitive RBD-5 than BA.1.1 BA.3,...