Although general characteristics of intraductal papillary mucinous neoplasms (IPMNs) and their delineation from other pancreatic tumors have been well established, several issues regarding biology management remain unresolved. It has noted briefly by us authors that there are different types papillae in IPMNs; however, frequency, biologic significance, clinical relevance unknown. In this study, the association patterns with clinical, pathologic, parameters was studied 74 IPMNs, expression...

Development and progression of many malignancies, including colorectal cancer, are associated with activation multiple signaling pathways. Therefore, inhibition these pathways noncytotoxic natural products represents a logical preventive and/or therapeutic approach for colon cancer. Curcumin resveratrol, both which inhibit the growth transformed cells carcinogenesis, were selected to examine whether combining them would be an effective strategy Indeed, combination curcumin resveratrol was...

Colorectal Cancer (CRC) is one of the leading causes death worldwide. Numerous cellular events, including deregulated expression microRNAs (miRNAs), specifically family miR-34 consisting miR-34a, b and c, known to regulate processes growth metastasis.We evaluated in formalin-fixed paraffin-embedded (FFPE) human colon cancer tissue specimens compared normal colonic mucosa. Moreover, we also assessed cell lines treated with our newly developed synthetic analogue curcumin referred as...

Acquired drug resistance is one of the major reasons for failing cancer therapies. Although are not fully understood, they may be related to presence stem cells (CSCs). We have reported that chemo-resistant (CR) colon cells, highly enriched in CSCs, exhibit a marked up-regulation miR-21 and down-regulation this miR renders CR more susceptible therapeutic regimens. However, underlying molecular mechanism poorly understood. The aim investigation unravel mechanism.The levels miR-145 were...

Accumulating evidence suggests that metformin, a biguanide class of anti-diabetic drugs, possesses anti-cancer properties. However, most the studies to evaluate therapeutic efficacy metformin have been on primary cancer. No information is available whether could be effectively used for recurrent cancer, specifically colorectal cancer (CRC) affects up 50% patients treated by conventional chemotherapies. Although reasons recurrence are not fully understood, it thought due re-emergence...

Background: Cutaneous lesions of pityriasis lichenoides et varioliformis acuta (PLEVA), a T cell-mediated cutaneous inflammatory condition, are clinically similar to lymphomatoid papulosis (LyP), leading some authors hypothesize that they part the same spectrum lymphoproliferative disorders, although reports development lymphoma in patients with PLEVA not as frequent for LyP.Furthermore, unlike cases LyP, no systematic search dominant T-cell clone has been carried out PLEVA, whereas clones...

adenomas or advanced responded better to folic acid supplementation.CONCLUSION: High dose supplementation is associated with a significant reduction in the recurrence of colonic suggesting that may be an effective chemopreventive agent for colorectal neoplasia.

There is no uniformly applied grading system for pancreatic ductal adenocarcinoma (DA). The scheme advocated by the WHO essentially that of Kloppel et al, and based on "highest grade" focus. Although it precise with good prognostic value, unfortunately not widely applied, largely because lack recognition partly its complex nature (interpretation multiple parameters). Furthermore, fundamentally different from one used in Japan, which evaluates overall pattern. To establish a more applicable,...

To determine whether and to what extent the gut microbiome is involved in regulating racial disparity colorectal cancer (CRC).All patients were recruited experiments performed accordance with relevant guidelines regulations by Institutional Review Boards (IRB), committees of John D. Dingell VAMC Wayne State University guidelines. African American (AA) Caucasian (CA) scheduled for an outpatient screening colonoscopy, no active malignancy volunteer doubly consented, initially...

CARP-1, a novel apoptosis inducer, regulates signaling by diverse agents, including adriamycin and growth factors. Epidermal factor receptor (EGFR)-related protein (ERRP), pan-ErbB inhibitor, inhibits EGFR stimulates apoptosis. Treatments of cells with ERRP or Iressa (an tyrosine kinase inhibitor) results in elevated CARP-1 levels, whereas antisense-dependent depletion causes inhibition ERRP. is tyrosine-phosphorylated protein, treatments cause phosphorylation CARP-1. contains multiple,...

Abstract TGF-β signaling plays critical roles in the pathogenesis of aneurysms; however, it is still unclear whether its role protective or destructive. In this study, we investigate SMAD3 calcium chloride (CaCl 2 )-induced abdominal aortic aneurysms (AAA) Smad3 −/− , +/− and +/+ mice. We find that loss drastically increases wall thickening aorta. Histological analyses show significant vessel remodeling with elastic fiber fragmentation. Remarkably, under polarized light, collagen fibers...

Increasing evidence supports the contention that many malignancies, including sporadic colorectal cancer, are driven by self-renewing, chemotherapy-resistant cancer stem/stem-like cells (CSC/CSLC), underscoring need for improved preventive and therapeutic strategies targeting CSCs/CSLCs. Omega-3 polyunsaturated fatty acids (ω-3 PUFA), have been reported to inhibit growth of primary tumors, but their potential as a agent recurring cancers is unexplored. The objectives this investigation (i)...

Lung cancer remains the most common worldwide, with a limited prognosis despite personalized treatment regimens. Low-dose computed tomography (CT) scanning as means of early diagnosis has been disappointing due to high false positive rate. Other non-invasive testing need be developed that offer both timely and predict prognosis. Methods: In course stool in large-scale 2922 patients at increased risk CRC, we were able ascertain 112 documented have prospectively diagnosed lung cancer. Stool...

Background: CD30‐positive cutaneous lymphoproliferative disorders (LPD) represent a spectrum of diseases ranging from low‐grade (lymphomatoid papulosis; LyP) to high‐grade (pleomorphic and anaplastic large‐cell lymphoma; PTL, ALCL) with overlapping morphologic immunophenotypic features. The common phenotypic hallmark is the expression CD30‐antigen by tumor cells which morphologically resemble Reed–Sternberg cells. Although LyP non‐fatal recurring disorder, it associated systemic lymphomas...

CARP-1/CCAR1, a perinuclear phosphoprotein, is regulator of cell growth and apoptosis signaling. Although CARP-1 chemotherapy-dependent apoptosis, it also part the NF-κB proteome co-activator steroid/thyroid nuclear receptors as well β-catenin Our yeast two-hybrid screen revealed binding with anaphase-promoting complex/cyclosome E3 ubiquitin ligase component APC-2 protein. binds co-activators Cdc20 Cdh1. Following mapping minimal epitopes involved in APC-2, fluorescence polarization assay...

Abstract Although African‐Americans ( AA s) have a higher incidence of colorectal cancer CRC ) than White people, the underlying biochemical mechanisms for this increase are poorly understood. The current investigation was undertaken to examine whether differences in self‐renewing stem/stem‐like cells CSC colonic mucosa, whose stemness is regulated by certain micro RNA s (miRs), could partly be responsible racial disparity . study contains 53 and 47 people. We found number adenomas...

Numerous dietary and pharmacological agents have been proposed as alternative strategies for treatment prevention of colorectal cancer. Curcumin, an active ingredient turmeric, that inhibits growth malignant neoplasms, has a promising role in the EGF-R related protein (ERRP), recently identified pan-erbB inhibitor, is potential therapeutic agent Here we examine whether curcumin together with ERRP will cause greater inhibition colon cancer cells than either alone mechanisms this inhibition....

One of the most consistent pathological conditions in gastrointestinal tract with advancing age is malignancy, particularly cancers, incidence which increases sharply aging. Although reasons for age-related rise colorectal cancer are not fully understood, we hypothesize that aging susceptibility colon to carcinogen(s)/toxicant(s), leading an increase stem-like cells (CSLCs) express stem cell markers, colonic mucosa. The current study demonstrates associated increased expression several CSLC...

To demonstrated the combined effects of aging and carcinogen treatment on cancer stem/stem-like cells (CSCs) gastric mucosa in an animal model.In this study we investigated Helicobacter pylori (H. pylori) inflammation as a model for induced carcinogenesis human rat samples. In studies, compared 4-mo old (young) with 22 mo (aged) Fischer-344 rats. For biopsies resection specimens representing normal or different stages H. gastritis adenocarcinomas were used determining expression stem cell...

The current study was undertaken to investigate the effect of differentially formulated polyphenolic compound Essential Turmeric Oil-Curcumin (ETO-Cur), and Tocotrienol-rich fraction (TRF) vitamin E isomers on colorectal cancer (CRC) cells that produce aggressive tumors. Combinations ETO-Cur TRF were used determine combinatorial effects TRF-mediated inhibition growth CRC in vitro HCT-116 xenograft SCID mice. 16S rRNA gene sequence profiling performed outcome gut microbial communities mice...