A5085956632- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Biomedical Ethics and Regulation
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer Risks and Factors
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Nuclear Structure and Function
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
The Barbara Ann Karmanos Cancer Institute
2016-2025
Wayne State University
2016-2025
Augusta University Health
2024
Presbyterian College
2024
Michigan United
2020
Detroit Medical Center
2012-2016
University of Alabama at Birmingham
2015
Texas Children's Hospital
2015
University of Houston
2015
Allegheny General Hospital
2015
Abstract cAMP responsive element-binding protein, hepatocyte specific (CREBH), is a liver-specific transcription factor localized in the endoplasmic reticulum (ER) membrane. Our previous work demonstrated that CREBH activated by ER stress or inflammatory stimuli to induce an acute-phase hepatic inflammation. Here, we demonstrate key metabolic regulator of lipogenesis, fatty acid (FA) oxidation, and lipolysis under stress. Saturated FA, insulin signals, atherogenic high-fat diet can...
Purpose Black/African American (AA) women are twice as likely to be diagnosed with triple negative breast cancer (TNBC) compared whites, an aggressive subtype associated poor prognosis. There no routinely used targeted clinical therapies for TNBC; thus there is a clear need identify prognostic markers and potential therapeutic targets. Methods We evaluated expression of 27,016 genes in 155 treatment-naïve TN tumors from AA Detroit. Associations survival were using Cox proportional hazards...
The epigenetic regulation of genes has long been recognized as one the causes prostate cancer (PCa) development and progression. Recent studies have shown that a number microRNAs (miRNAs) are also epigenetically regulated in different types cancers including PCa. In this study, we found DNA sequence promoters miR-29a miR-1256 partly methylated PCa cells, which leads to their lower expression both cells human tumor tissues compared with normal epithelial tissues. By real-time PCR, Western...
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease urgently requiring new treatments. Overexpression of the protein transporter exportin-1 (XPO1) leads to mislocalization tumor-suppressor proteins (TSP) and their inactivation. Earlier, we showed that blocking XPO1 by CRISPR/Cas9 validated Selective Inhibitor Nuclear Export (SINE) compounds (selinexor analogs) restores antitumor activity multiple TSPs leading suppression PDAC in vitro orthotopic models.We evaluate synergy...
Purpose This was a phase I/II adoptive T cell trial in 7 locally advanced and metastatic pancreatic cancer patients using 3-8 infusions of anti-CD3 x anti-EGFR bispecific antibody armed activated cells (BATs) to determine safety, the maximum tolerated dose (MTD), immune responses, time progression (TTP), overall survival (OS).
Increasing evidence supports the contention that many malignancies, including sporadic colorectal cancer, are driven by self-renewing, chemotherapy-resistant cancer stem/stem-like cells (CSC/CSLC), underscoring need for improved preventive and therapeutic strategies targeting CSCs/CSLCs. Omega-3 polyunsaturated fatty acids (ω-3 PUFA), have been reported to inhibit growth of primary tumors, but their potential as a agent recurring cancers is unexplored. The objectives this investigation (i)...
// Young-Suk Jung 1, 7, * , Abdo J. Najy Wei Huang 1 Seema Sethi Michael Snyder 2, 3 Wael Sakr Gregory Dyson 2 Maik Hüttemann 4 Icksoo Lee 4, 8 Rouba Ali-Fehmi Silvia Franceschi 5 Linda Struijk 6 Harold E. Kim Ikuko Kato and Hyeong-Reh Choi Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School Medicine, Detroit, MI, USA Oncology, Division Radiation Center for Molecular Medicine Genetics, International Agency Research on Cancer, Lyon, France DDL...
While up to 25% of ovarian cancer (OVCA) cases are thought be due inherited factors, the majority genetic risk remains unexplained. To address this gap, we sought identify previously undescribed OVCA variants through whole exome sequencing (WES) and candidate gene analysis 48 women with selected for high inheritance, yet negative any known pathogenic in either BRCA1 or BRCA2. In silico SNP was employed suspect followed by validation using Sanger DNA sequencing. We identified five our sample,...
Background: While NPM1-mutated AML in the absence of FLT3-ITD generally carries a favorable prognosis, large registry studies suggest positive prognostic benefit may not extend to patients > 65 years age. We examined this preferential, age-dependent impact through real-world analysis 2811 adult patients. Results: The median overall survival (OS) was significantly better NPM1MT compared NPM1WT [20.86 vs. 17 mo., p = 0.003]. When stratified by age, had higher OS than 55–65-year age group...
<p>Gene mutations according to poverty level and RUCA codes</p>
<p>Overall survival by RUCA code and poverty</p>
<p>Comparison of overall survival among chemotherapy-treated TP53-mutated and TP53-wild type patients in Caris CODEai clinico-genomic database</p>
<p>Comparison of Caris cohort data with Puckrein dataset</p>
<p>Overall survival by RUCA code and poverty</p>
<p>Copy number alterations (CNAs) and fusions among cohort</p>
<p>Overall survival of cohort by stage</p>
<p>Prevalence of common mutations in tumor subtypes</p>
Abstract Background: Dysregulated nuclear protein transport, commonly observed in cancer, results the mislocalization-mediated inactivation of many proteins. We showed that overexpression exportin 1 (XPO1) is linked to higher grade and Gleason score metastatic castration-resistant prostate cancer (mCRPC). Using network topology computational approaches, XPO1 PARP1 were identified as synthetic lethal partners we have demonstrated synergy between PARP inhibitors mCRPC cell lines. This study...
Abstract Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show minimal response to FDA-approved therapies suggesting an urgent need for the identification of novel and effective therapeutic targets. Aberrant nuclear protein transport cytoplasm, often observed in cancer, causes mislocalization-dependent inactivation critical cellular proteins. The major exporter exportin-1 (XPO1) has been linked cancer therapy resistance. Nevertheless, role XPO1 GEP-NETs not explored. Major...
Abstract Introduction: The KRASG12D inhibitor MRTX1133, which targets KRAS in the OFF-state, is currently under evaluation pancreatic ductal adenocarcinoma (PDAC) patients. However, as seen with other OFF-state inhibitors, MRTX1133 may provide only limited improvements disease-free survival due to emergence of drug resistance. This highlights need for strategies enhance efficacy inhibitors PDAC. nuclear transport protein, XPO1, plays a significant role several pro-tumorigenic pathways and...