A5103150156- Acute Myeloid Leukemia Research
- Dialysis and Renal Disease Management
- Pharmaceutical industry and healthcare
- Heat shock proteins research
- Chronic Myeloid Leukemia Treatments
- Poisoning and overdose treatments
- Genetic factors in colorectal cancer
- Membrane Separation Technologies
- Cancer Genomics and Diagnostics
- Pharmaceutical Economics and Policy
- Central Venous Catheters and Hemodialysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Plant responses to elevated CO2
- Mineral Processing and Grinding
- Burn Injury Management and Outcomes
- Mycobacterium research and diagnosis
- Renal function and acid-base balance
- Membrane-based Ion Separation Techniques
- Retinal Diseases and Treatments
- Vascular Procedures and Complications
- Microwave and Dielectric Measurement Techniques
- Liver Disease and Transplantation
- Graphene and Nanomaterials Applications
- Microbial Inactivation Methods
- Patient-Provider Communication in Healthcare
Wayne State University
2021-2025
The Barbara Ann Karmanos Cancer Institute
2024
Detroit Medical Center
2021-2023
University of California, San Diego
2019-2020
Michigan State University
2008-2015
HemoCleanse (United States)
1996-2008
University of Kansas
2006-2007
LAC+USC Medical Center
2002
University of New Mexico
2002
St. Elizabeth Hospital in Enumclaw
1998
Summary A random sample of Wisconsin dairy herds, stratified by herd size, were tested for paratuberculosis use an absorbed ELISA procedure. The was optimized overall accuracy means receiver operating characteristic curve analysis, and had a sensitivity specificity 50.9 94.9%, respectively. Herd prevalence analyzed correlation with responses to management practices questionnaire completed the owners. One hundred fifty-eight herds 4,990 cattle tested. Of these, 50% 7.29% positive test...
Summary A new understanding of leaf starch degradation has emerged in the last 10 years. It been shown that phosphorylation and dephosphorylation are critical components this process. Glucan, water dikinase (GWD) (and phosphoglucan, dikinase) adds phosphate to starch, phosphoglucan phosphatase (SEX4) removes these phosphates. To explore use metabolism manipulate accumulation, Arabidopsis ( thaliana ) plants were engineered by introducing RNAi constructs designed reduce expression AtGWD...
Background: While NPM1-mutated AML in the absence of FLT3-ITD generally carries a favorable prognosis, large registry studies suggest positive prognostic benefit may not extend to patients > 65 years age. We examined this preferential, age-dependent impact through real-world analysis 2811 adult patients. Results: The median overall survival (OS) was significantly better NPM1MT compared NPM1WT [20.86 vs. 17 mo., p = 0.003]. When stratified by age, had higher OS than 55–65-year age group...
The BioLogic-DT (detoxifier) System is an extracorporeal blood treatment device that uses the membranes of a cellulosic plate dialyzer to propel in and out through single lumen access (on 12 sec cycle) circulates suspension powdered charcoal cation exchanger dialysate spaces absorb many soluble toxins hepatic failure. BioLogic-DTPF (detoxifier/plasma filter) adds two Gambro plasma filters downstream from dialyzer, which allows most pass blood, contact suspension, then return during each...
A randomized trial of the GRAIL Galleri TM multi-cancer screening test is being planned for National Health Service in England, and will have 140,000 healthy participants aged 50–79: 70,000 exposed to unexposed. The reportedly detects 50 different cancers expected reduce all-cancer mortality by approximately 25%. Given this effect size—and that cancer deaths constitute a large fraction all deaths—the sufficiently on all-cause mortality. Because most patients believe “saves lives”,...
In sorbent-based hemodialysis, factors limiting a treatment session are urea conversion capacity and sodium release from the cartridge. vitro experiments were performed to model typical scenarios using various dialyzers 4 types of SORB sorbent cartridges. The continued point column saturation with ammonium. nitrogen removed amount released in each trial analyzed multi-variable regression against several variables: zirconium phosphate (ZrP), dialysate flow rate (DFR), simulated blood (BFR),...
A 56-year-old male presented with ascites and gynecomastia. Laparoscopy demonstrated peritoneal tumors which were biopsied. Conventional histology electron microscopy revealed the tumor to be a malignant mesothelioma. The ascitic fluid cell lysate, but not serum, contained hCG by specific assay, immunoreactive had characteristics similar purified in filtration on Sephadex G-100. Malignant mesothelioma is may associated elevated concentrations. Demonstration of should suggest presence neoplasm.
6542 Background: RUNX1is a master regulator of hematopoiesis. ELN2022 risk stratification categorizes RUNX1 as an AML/MDS gene associated with poor prognosis. Functional domains in RUNX1are the Runt homology domain (RHD) and transactivation (TAD), DNA binding co-activator recruitment functions, respectively. Domain-based analysis can elucidate functional biological impact somatic RUNX1mutations, which have not yet been reported literature. Methods: Sequencing data from Karmanos Cancer...
6583 Background: Myeloid sarcoma (MS) is an atypical, extramedullary manifestation of acute myeloid leukemia. Next-generation sequencing (NGS) studies have explored mutational profiles MS tumor sites and bone marrow (BM) samples. However, site-specific molecular patterns concordance/discordance between BM remain unclear. Methods: Relevant about retrieved from a Pubmed search (1999-2023) with information site involvement NGS data were included. With R software, meta-analysis (MA) descriptive...
Introduction : Microsatellites are short, repetitive portions of DNA that error prone during replication; several mismatch repair proteins recognize and these errors. Deficient MMR (dMMR) results in microsatellite instability (MSI), a well-recognized carcinogenic pathway. In Lynch syndrome (LS), germline mutations genes predispose to colorectal (CRC) endometrial carcinoma (EC), among others. Immune checkpoint inhibitors (ICI), such as pembrolizumab, approved treat dMMR or MSI-high (MSI-H)...
Abstract: Doppler ultrasound is a noninvasive technique for monitoring moving objects such as flowing blood while ignoring stationary shunt tubing. A system was investigated to determine its sensitivity in detecting particulate release during hemodialysis. Seven hemodialysis procedures with dogs and six trials humans were done using sorbent suspension reciprocating dialyzer (SSRD). Two additional cellulose acetate hollow‐fiber (HFD). large increase (approximately twofold) found the reflected...