A5115529142- Sperm and Testicular Function
- Cardiac pacing and defibrillation studies
- Hematological disorders and diagnostics
- Cardiac Arrhythmias and Treatments
- Hemoglobinopathies and Related Disorders
- Reproductive Biology and Fertility
- Antifungal resistance and susceptibility
- Acute Myeloid Leukemia Research
- Cardiovascular Effects of Exercise
- Acute Lymphoblastic Leukemia research
- Blood donation and transfusion practices
- Palliative Care and End-of-Life Issues
- Platelet Disorders and Treatments
- Cardiac Arrest and Resuscitation
- Iron Metabolism and Disorders
- Occupational and environmental lung diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Health and Biochemistry
- Disaster Response and Management
- Cardiac tumors and thrombi
- Blood groups and transfusion
- Nail Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Fungal Infections and Studies
- Cardiac Structural Anomalies and Repair
HelpAge International
2024
Lady Hardinge Medical College
2010-2024
Indian Institute of Information Technology Allahabad
2024
Tribhuvan University
2024
Sanford Health
2020-2022
University of North Dakota
2020-2022
Sanford Medical Center
2022
University of Oslo
2021
Lahey Medical Center
2016-2020
Woodhull Medical and Mental Health Center
2020
Pancytopenia is a common occurrence in pediatric patients. Though acute leukemias and bone marrow failure syndromes are usual causes of pancytopenia, etiologies such as infections megaloblastic anemia also contribute. The aim this study was to evaluate the clinico-hematological profile varying degrees childhood cytopenias with special reference non-malignant presentations. This retrospective carried out tertiary care children's hospital. We retrospectively analyzed 109 patients who presented...
Dithiocarbamate compound Disulfiram (DSF) that binds with copper and functions as an inhibitor of aldehyde dehydrogenase is a Food Drug Administration approved agent for treatment alcoholism. Copper complexed DSF (DSF-Cu) also possesses anti-tumor chemosensitizing properties; however, its molecular mechanisms action remain unclear. Here we investigated malignant pleural mesothelioma (MPM) suppressive effects DSF-Cu the involved. inhibited growth murine well human MPM cells in part by...
A case of necrotizing fasciitis the anterior abdominal wall caused by zygomycete Apophysomyces elegans in a healthy male following inguinal herniorrhaphy is reported. The portal entry fungus into incised skin and subcutaneous tissues was probably through either contaminated surgical sutures or postoperative dressings. Broad, aseptate fungal hyphae were seen necrosed with an associated vasculitis. Extensive tissue debridements low dose amphotericin B not successful controlling rapid invasion fungus.
Pacemaker infection with Mycobacterium fortuitum has not been reported previously. We describe a case of pacemaker generator pocket and intravascular lead endocarditis due to fortuitum. The entire pacing system was removed the patient treated successfully multidrug regimen for total 6 months.
Without experience or proper training, the evaluation of morphologic features sperm can become most confusing and time-consuming area semen analysis. This study defined role Papanicolaou staining compared with an automated analyzer in management infertility. We using Sperm Quality Analyzer IIC-P (SQA-IIC-P; Medical Electronic Systems, Caesarea, Israel) evaluated factors affecting these samples from 201 infertile men. The sensitivity SQA-IIC-P was 85.5%, specificity 87.3% staining. Although...
Fresh frozen plasma (FFP) transfusion is among the highest risk of all blood component transfusions and also most inappropriately used component. All these factors have impact on safety, economy, work burden.To assess utilization FFP in a tertiary care hospital.Concurrent audit was conducted manually over period 4 months from April 2010 to July 2010. Patient's age, sex, clinical diagnosis, indication for transfusion, coagulation profile were noted. Data analysed episodes divided into...
Hypertension is a major risk factor for cardiovascular disease, which the leading cause of premature mortality and morbidity globally. Despite evidences availability effective treatment hypertension, its management remains suboptimal. Medication adherence most crucial blood pressure control. It important to identify factors associated with antihypertensive better management. Hence, this study assessed level medication among patients hypertension visiting tertiary-level hospital in Kathmandu,...
Summary. A fatal case of craniofacial zygomycosis caused by Apophysomyces elegans in a 52‐year‐old man was diagnosed the presence broad aseptate, branched hyaline hyphae tissue from paranasal sinuses and surrounding areas, isolation fungus same tissue. The patient suffered idiopathic myelofibrosis as underlying disease, he thrombocytopenic mildly hyperglycaemic. infection represents second due to A. . Zusammenfassung. Bei einem 52 Jahre alten Patienten mit idiopathischer Myelofibrose,...
Objective: To report the observations on various bleeding manifestations in children with immune thrombocytopenic purpura (ITP) having severe thrombocytopenia (platelet count (PC) < 20,000/μl) and to compare differences at levels of PC 10,000/μl compared between 10,000 20,000/μl. Study design: It is a retrospective analysis ITP (n = 58) recorded July 1999 June 2002. A total 164 episodes were observed. During 31 (18.9%), no When was observed cutaneous bleeds commonest occurring 124 episodes....
Thrombophilias, both acquired and inherited, have been investigated in the etiopathogenesis of unexplained recurrent pregnancy loss.To study coagulation inhibitors activated protein C resistance (APCR) losses (RPL) occurring second third trimesters.A total 30 pregnant women (group A) with two or more fetal loses were evaluated for APCR, deficiency, S antithrombin antiphospholipid antibodies (APLA). Thirty age-matched controls taken B) comprising at least one live issue.Comparisons between...
Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as distinct entity for very long time, because lack clinical features and morphological criteria, it difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, immunocytochemical five cases AMKL. Certain such presence abnormal platelet count, giant platelets, cytoplasmic blebbing in blasts were found be important pointers towards diagnosis....
Background: Variable temperature in different seasons may affect the quality of semen. Most studies are from west barring a single large Chinese study with variable results; however, no such focusing on alone has been published Indian subcontinent. Present was undertaken to observe any seasonal variation affecting semen at times year.Methods: The conducted retrospectively over one year period (2014-2015) tertiary care hospital North India. 815 samples referred infertility clinic were...
First-line therapies of acute and chronic idiopathic thrombocytopenic purpura (ITP) include intravenous immunoglobulin, IV anti-D corticosteroids. A short-course high-dose dexamethasone (HDD-SC) therapy has recently been reported to be efficacious in ITP. The present study was conducted assess the efficacy HDD-SC children with Over a period 10 months, 13 patients ITP were given (20 mg m(-2) daily for 4 days, four cycles repeated every 15 days). Of 12 who could evaluated, complete response...
Besides angiotensin converting enzyme 2 (ACE2), an active involvement of proteases (FURIN and/or TMPRSS2) is important for cellular entry SARS-CoV-2. Therefore, a simultaneous expression profiling proteins in tissue might provide better risk assessment SARS-CoV-2 infection as compared to individual proteins. In attempt understand the relative susceptibility oral squamous cell carcinoma (OSCC) lesions normal mucosa (NOM) attachment/entry, this study examined mRNA and protein profiles ACE2,...
Background: Iron deficiency anemia is a major cause of morbidity in developing countries like India. The aim the study was to assess abnormalities platelet count iron and relate severity thrombocytosis with its association erythropoietin (EPO) level.Methods: A prospective observational comprising 200 children below 18 years confirmed have IDA. Erythropoietin level done patients who had thrombocytosis. Degree correlated EPO also ferritin, haematological indices hemoglobin MCV (mean...
Abstract Clinically apparent jaundice is unusual in patients with β‐thalassemia major. Co‐inheritance of Gilbert syndrome has been reported to cause hyperbilirubinemia these subjects. Crigler–Najjar another rare disorder bilirubin metabolism caused by mutation the gene coding enzyme UGT1A1. We report a patient major who presented persistent due co‐inherited type 2 secondary novel UGT1A1 [homozygous base substitution at position 362 (GGT>AGT) exon 3]. Pediatr Blood Cancer 2010;54:627–628....