A5024567376- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Cardiac and Coronary Surgery Techniques
- Synthesis and biological activity
- Organic Chemistry Cycloaddition Reactions
- Sustainable Building Design and Assessment
- Sepsis Diagnosis and Treatment
- Estrogen and related hormone effects
- Cardiac electrophysiology and arrhythmias
- Cytokine Signaling Pathways and Interactions
- Advanced MRI Techniques and Applications
- Synthesis and Characterization of Heterocyclic Compounds
Mayo Clinic
2015-2024
Mayo Clinic in Arizona
2015-2024
WinnMed
1994-2021
Mayo Clinic in Florida
1996-2021
Capital Medical University
2013
Konyang University
2013
University Hospital of Zurich
2013
University of Oxford
2012
Brigham and Women's Hospital
2012
University of Minnesota Rochester
2001-2012
In patients undergoing percutaneous coronary intervention (PCI) in the modern era, incidence and prognostic implications of acute renal failure (ARF) are unknown.With a retrospective analysis Mayo Clinic PCI registry, we determined of, risk factors for, ARF (defined as an increase serum creatinine [Cr] >0.5 mg/dL from baseline) after PCI. Of 7586 patients, 254 (3.3%) experienced ARF. Among with baseline Cr <2.0, was higher among diabetic than nondiabetic whereas those >2.0, all had...
Quality improvement efforts have focused on strategies to improve the timeliness of reperfusion therapy in ST-elevation myocardial infarction patients who present hospitals with and without percutaneous coronary intervention (PCI) capability. We implemented evaluated a protocol optimize coordinate systems care for PCI center 28 regional located up 150 miles away across 3 states.The study prospective, observational cohort 597 presented ST-segment elevation within 12 hours symptom onset Saint...
Background— In 2000, the definition of myocardial infarction (MI) changed to rely on troponin rather than creatine kinase (CK) and its MB fraction (CK-MB). The implications this change trends in MI incidence outcome are not defined. Methods Results— This was a community study 2816 patients hospitalized with incident from 1987 2006 Olmsted County, Minnesota, prospective measurements CK-MB August 2000 forward. Outcomes were incidence, severity, survival. After introduced, 278 (25%) 1127 MIs...
<h3>Importance</h3> After percutaneous coronary intervention (PCI), patients with<i>CYP2C19*2</i>or<i>*3</i>loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection oral P2Y12 inhibitor therapy improves outcomes is unknown. <h3>Objective</h3> To determine the effect a strategy on in<i>CYP2C19</i>LOF carriers after PCI. <h3>Design, Setting, and Participants</h3> Open-label randomized clinical trial 5302 undergoing PCI...
Abstract Objective To evaluate the predictive value of neurologic prognostic indicators for patients treated with hypothermia after surviving cardiopulmonary arrest. Methods Patients who survived arrest were prospectively collected from June 2006 to October 2009. Detailed examinations performed. Serum neuron specific enolase (NSE) measurements, brain imaging findings, somatosensory evoked potentials, and electroencephalogram (EEG) results recorded. EEG patterns blindly dichotomized malignant...
Background The endothelium modulates vascular tone through release of vasodilating substances, such as endothelium-derived relaxing factors, and vasoconstricting endothelin. Endothelin concentrations are elevated in humans with atherosclerosis hypercholesterolemic pigs. Furthermore, the endothelium-dependent vasodilator acetylcholine increases endothelin hypercholesterolemia association coronary vasoconstriction. present study was designed to test hypotheses that endothelial dysfunction is...
BACKGROUND Complete revascularization after coronary artery bypass surgery is a logical goal and improves symptomatic outcome survival. However, the impact of complete in patients with three-vessel disease varying severities angina left ventricular dysfunction has not been clearly defined. METHODS AND RESULTS The study was performed as retrospective analysis 3,372 nonrandomized surgical from Coronary Artery Surgery Study (CASS) Registry who had disease. Group 1 (894 patients) class I or II...
Pravadoline (1) is an (aminoalkyl)indole analgesic agent which inhibitor of cyclooxygenase and, in contrast to other NSAIDs, inhibits neuronally stimulated contractions mouse vas deferens (MVD) preparations (IC50 = 0.45 microM). A number conformationally restrained heterocyclic analogues pravadoline were synthesized the morpholinoethyl side chain was tethered indole nucleus. Restraining morpholine diminished ability these inhibit prostaglandin synthesis vitro. In contrast, inhibitory...
Concern regarding risk of late thrombosis after "off-label" treatment with drug-eluting stents has prompted increased use bare-metal (BMS) in current practice. The sequelae BMS failures, however, have been poorly characterized.We performed a retrospective study 4503 consecutive patients treated at least 1 and dual antiplatelet therapy between 1994 2000. cumulative incidence stent was 0.5% 30 days (95% CI, 0.3% to 0.7%), 0.8% year 0.6% 1.1%), 2.0% 10 years 1.5% 2.5%). Risk (30 year) very (>1...
Background— The relationship between neutrophils and outcomes post–myocardial infarction (MI) is not completely characterized. We examined the associations of neutrophil count with mortality post-MI heart failure (HF) their incremental value for risk discrimination in community. Methods Results— MI was diagnosed cardiac pain, biomarkers, Minnesota coding ECG. Neutrophil at presentation, reported as counts ×10 9 /L, categorized by tertiles (lower tertile, <5.7; middle 5.7 to 8.5; upper...
Coronary balloon angioplasty of chronic total occlusions is associated with relatively low success rates and a high incidence restenosis. Whether there long-term benefit in performing these lesions unknown. The purpose the present report was to analyze outcome large series patients undergoing this procedure.A computerized database analysis 354 consecutive (from 1979 1990) who underwent coronary occlusion performed (mean age, 62.3 years). Initial technical achieved 69%; 66%, without...
The use of exercise echocardiography for the diagnosis coronary artery disease (CAD) has been validated in pilot studies but is not documented clinical practice and women comparatively with men. objectives this study were to determine effects sex test verification bias on diagnostic performance echocardiography.Three thousand six hundred seventy-nine consecutive patients (1714 women, 1965 men) who underwent an echocardiographic studied; observed sensitivity, specificity, correct...
Aims
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE STRUCTURE OF GLIOTOXINMalcolm R. Bell, John Johnson, Bernard S. Wildi, and B. WoodwardCite this: J. Am. Chem. Soc. 1958, 80, 4, 1001Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February 1958https://pubs.acs.org/doi/10.1021/ja01537a065https://doi.org/10.1021/ja01537a065research-articleACS PublicationsRequest reuse permissionsArticle Views483Altmetric-Citations101LEARN ABOUT THESE...
Background: Rehospitalization is a quality-of-care indicator, yet little known about its occurrence and predictors after myocardial infarction (MI) in the community. Objective: To examine 30-day rehospitalizations incident MI. Design: Retrospective cohort study. Setting: Population-based registry Olmsted County, Minnesota. Patients: 3010 patients who were hospitalized County with first-ever MI from 1987 to 2010 survived hospital discharge. Measurements: Diagnoses, therapies, complications...
Background: Extracorporeal membrane oxygenation (ECMO) is increasingly used in acute myocardial infarction (AMI); however, there are limited large-scale national data. Methods: Using the National Inpatient Sample database from 2000 to 2014, a retrospective cohort of AMI utilizing ECMO was identified. Use percutaneous coronary intervention, intra-aortic balloon pump, and left ventricular assist device (LVAD) also identified this population. Outcomes interest included temporal trends...