A5009413704- Antiplatelet Therapy and Cardiovascular Diseases
- Neurotransmitter Receptor Influence on Behavior
- Ethics in Clinical Research
- Medication Adherence and Compliance
- Cannabis and Cannabinoid Research
- Pharmaceutical industry and healthcare
- Blood Pressure and Hypertension Studies
- Criminal Justice and Corrections Analysis
- Substance Abuse Treatment and Outcomes
- Neurogenetic and Muscular Disorders Research
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Healthcare Decision-Making and Restraints
- Amyotrophic Lateral Sclerosis Research
- Artificial Intelligence in Healthcare and Education
- Mobile Health and mHealth Applications
- Biomedical and Engineering Education
- Pharmaceutical Economics and Policy
- Health disparities and outcomes
- Digital Mental Health Interventions
- Social Media in Health Education
- Receptor Mechanisms and Signaling
- Pharmaceutical Practices and Patient Outcomes
- Acute Myocardial Infarction Research
- Synthesis of β-Lactam Compounds
National Heart Lung and Blood Institute
2016-2024
National Institutes of Health
2011-2024
Ottawa University
2023
Yale University
2021
Arizona State University
2017
National Institute on Drug Abuse
2011-2014
The University of Texas Health Science Center at San Antonio
1998-1999
Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1β, resulted in lower rate of cardiovascular events than placebo previous randomized trial. We sought determine whether an alternative approach inhibition low-dose methotrexate might provide similar benefit.We conducted randomized, double-blind trial (at target dose 15 20 mg weekly) or matching 4786 patients myocardial infarction...
<h3>Importance</h3> After percutaneous coronary intervention (PCI), patients with<i>CYP2C19*2</i>or<i>*3</i>loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection oral P2Y12 inhibitor therapy improves outcomes is unknown. <h3>Objective</h3> To determine the effect a strategy on in<i>CYP2C19</i>LOF carriers after PCI. <h3>Design, Setting, and Participants</h3> Open-label randomized clinical trial 5302 undergoing PCI...
ABSTRACT Aims Topiramate has shown efficacy at facilitating abstinence from alcohol and cocaine abuse. This double‐blind, placebo‐controlled out‐patient trial tested topiramate for treating methamphetamine addiction. Design Participants ( n = 140) were randomized to receive or placebo (13 weeks) in escalating doses 50 mg/day the target maintenance of 200 weeks 6–12 (tapered week 13). Medication was combined with weekly brief behavioral compliance enhancement treatment. Setting The conducted...
Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group discuss POCT in medicine. multidisciplinary group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, program staff, reviewed the state of field; discussed opportunities for care, realize precision medicine, advance...
As we commemorate the 70
Developing efficacious medications to treat methamphetamine dependence is a global challenge in public health. Topiramate (TPM) undergoing evaluation for this indication. The molecular mechanisms underlying its effects are largely unknown. Examining the of TPM on genome-wide gene expression addicts clinically and scientifically important component understanding therapeutic profile.In double-blind, placebo-controlled clinical trial, 140 individuals who met DSM-IV criteria were randomized...
The commercialization of new point care technologies holds great potential in facilitating and advancing precision medicine heart, lung, blood, sleep (HLBS) disorders. delivery individually tailored health to a patient depends on how well that patient's condition can be interrogated monitored. Point may enable access rapid cost-effective interrogation near real time. Currently, physiological data are largely limited single-time-point collection at the hospital or clinic, whereas critical...
Between 2018 and 2019, multiple clinical trials ended earlier than planned, resulting in calls to improve communication with support for participants their study partners ("dyads"). The multidisciplinary Participant Follow-Up Improvement Research Studies Trials (Participant FIRST) Work Group met throughout 2021. Its goals were identify best practices communicating supporting dyads affected by early trial stoppage. FIRST identified 17 key recommendations spanning the pre-trial, mid-trial,...
The Tailored Antiplatelet Initiation to Lessen Outcomes Due Decreased Clopidogrel Response After Percutaneous Coronary Intervention (TAILOR-PCI) Digital Study is a novel proof-of-concept study that evaluated the feasibility of extending TAILOR-PCI randomized controlled trial (RCT) follow-up period by using remote digital platform.The aim this describe patients' onboarding, engagement, and results in after enrollment an RCT.In intervention study, previously enrolled patients United States...
Accurate, timely ascertainment of clinical end points, particularly hospitalizations, is crucial for trials. The Tailored Antiplatelet Initiation to Lessen Outcomes Due Decreased Clopidogrel Response after Percutaneous Coronary Intervention (TAILOR-PCI) Digital Study extended the main TAILOR-PCI trial's follow-up 2 years, using a smartphone-based research app featuring geofencing-triggered surveys and routine monthly mobile phone detect cardiovascular (CV) hospitalizations. This pilot study...
Developing efficacious medications to treat methamphetamine dependence is a global challenge in public health. Topiramate (TPM) undergoing evaluation for this indication. The molecular mechanisms underlying its effects are largely unknown. Examining the of TPM on genome-wide gene expression addicts clinically and scientifically important component understanding therapeutic profile. In double-blind, placebo-controlled clinical trial, 140 individuals who met DSM-IV criteria were randomized...
Despite a growing aging population in the correctional system, older persons are often released from jail unprepared for transition to free world and unable access necessary medications. This article proposes discharge form (transitional care tool) that may improve medical provided inmates upon release jail, especially regarding their compliance with prescribed The authors developed tool three-step process: (1) review concerns raised pertinent literature, (2) expert panel determination of...
<sec> <title>BACKGROUND</title> Accurate, timely ascertainment of clinical end points, particularly hospitalizations, is crucial for trials. The Tailored Antiplatelet Initiation to Lessen Outcomes Due Decreased Clopidogrel Response after Percutaneous Coronary Intervention (TAILOR-PCI) Digital Study extended the main TAILOR-PCI trial's follow-up 2 years, using a smartphone-based research app featuring geofencing-triggered surveys and routine monthly mobile phone detect cardiovascular (CV)...