A5084136529- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- ATP Synthase and ATPases Research
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- HIV-related health complications and treatments
- Mechanical Circulatory Support Devices
- Sirtuins and Resveratrol in Medicine
- Cardiovascular and exercise physiology
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
- High Altitude and Hypoxia
- Metabolism and Genetic Disorders
- Health, Environment, Cognitive Aging
- Adipose Tissue and Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Anesthesia and Neurotoxicity Research
- Cardiac Health and Mental Health
- Metabolomics and Mass Spectrometry Studies
- Xenotransplantation and immune response
- Vitamin C and Antioxidants Research
- Calcium signaling and nucleotide metabolism
National Institutes of Health
2012-2025
National Heart Lung and Blood Institute
2012-2025
Lee Memorial Health System
2020
Florida State University
2020
Clinton Health Access Initiative
2016
University of Washington
2015
Johns Hopkins University
2008-2015
University of California, Davis
2012-2015
University of California, San Diego
2015
Rush University Medical Center
2015
Inhibition of glycogen synthase kinase (GSK)-3 reduces ischemia/reperfusion injury by mechanisms that involve the mitochondria. The goal this study was to explore possible molecular targets and mechanistic basis cardioprotective effect. In perfused rat hearts, treatment with GSK inhibitors before ischemia significantly improved recovery function. To assess effect on mitochondrial function under ischemic conditions, mitochondria were isolated from hearts treated uncoupler or cyanide made...
Rationale: Mice lacking cyclophilin D (CypD −/− ), a mitochondrial chaperone protein, have altered cardiac metabolism. As acetylation has been shown to regulate metabolism, we tested whether changes in protein might play role these metabolic CypD hearts. Objective: Our aim was test the hypothesis that loss of alters acetylome. Methods and Results: To identify lysine-acetylated proteins map sites after ablation CypD, subjected tryptic digests isolated mitochondria from wild-type mice...
Heart failure (HF) is a well-described final common pathway for broad range of diseases however substantial confusion exists regarding how to describe, study, and track these underlying etiologic conditions. We describe (1) the overlap in HF etiologies, comorbidities, case definitions as currently used registries led or managed by members global roundtable; (2) strategies improve quality evidence on etiologies modifiable risk factors registries; (3) opportunities use clinical platform public...
As we commemorate the 70
Evolution has provided a number of animal species with extraordinary phenotypes. Several these phenotypes allow to survive and thrive in environmental conditions that mimic disease states humans. The study evolved mechanisms responsible for may provide insights into the basis human guide design new therapeutic approaches. Examples include tolerate acute or chronic hypoxemia like deep-diving mammals high-altitude inhabitants, as well those hibernate interrupt their development when exposed...
Journal Article Acute haemodynamic and myocardial metabolic effects of intravenous urapidil in severe heart failure Get access R. Y. C. WANG, WANG University Department Medicine, Queen Mary HospitalHong Kong Requests for reprints to: Dr Wang, Hospital, Pokfulam Road, Hong Kong. Search other works by this author on: Oxford Academic PubMed Google Scholar J. S. F. CHOW, CHOW K. H. CHAN, CHAN M. PAN, PAN P. WONG European Heart Journal, Volume 5, Issue 9, September 1984, Pages 745–751,...
Recent data have shown that cardioprotection can result in the import of specific proteins into mitochondria a process involves heat shock protein 90 (HSP90) and is blocked by geldanamycin (GD), HSP90 inhibitor. To test hypothesis an alteration mitochondrial more widespread feature cardioprotection, this study, we used broad-based proteomics approach to investigate changes proteome following induced inhibition glycogen synthase kinase (GSK)-3. Mitochondria were isolated from control hearts,...
Mitochondrial biology is the sum of diverse phenomena from molecular profiles to physiological functions. A mechanistic understanding mitochondria in disease development, and hence future prospect clinical translations, relies on a systems-level integration expertise multiple fields investigation. Upon successful conclusion recent National Institutes Health, Heart, Lung, Blood Institute initiative integrative mitochondrial cardiovascular diseases, we reflect accomplishments made possible by...