A5053050339- Xenotransplantation and immune response
- Organ Donation and Transplantation
- Neuroethics, Human Enhancement, Biomedical Innovations
- Ethics in medical practice
- Anesthesia and Neurotoxicity Research
- Organ Transplantation Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Biomedical Ethics and Regulation
- Air Quality and Health Impacts
- Palliative Care and End-of-Life Issues
- Vaccine Coverage and Hesitancy
- Ethics in Clinical Research
- Health and Conflict Studies
- Pluripotent Stem Cells Research
- SARS-CoV-2 and COVID-19 Research
- Climate Change and Health Impacts
- Theology and Philosophy of Evil
- Innovations in Medical Education
- Grief, Bereavement, and Mental Health
- Patient Dignity and Privacy
- CRISPR and Genetic Engineering
- Health Systems, Economic Evaluations, Quality of Life
- Estrogen and related hormone effects
- Ethics and Legal Issues in Pediatric Healthcare
- Bacillus and Francisella bacterial research
Rowan University
2020-2025
Stratford University
2024
Stanford University
2021
Family Medicine Residency of Idaho
2020
University of Alabama at Birmingham
2019-2020
WellStar Health System
2018-2020
Weatherford College
2020
Duquesne University
2016-2017
Defence Science and Technology Laboratory
2012
Texas Tech University Health Sciences Center
2010-2012
Pulmonary involvement in mixed connective tissue disease (MCTD) is common, frequently severe, and often clinically inapparent variably responsive to corticosteroid/cyclophosphamide treatment. Serial pulmonary evaluation of patients with MCTD important, since deterioration, as the diffusing capacity over time, may alert physician need for more invasive evaluation. Patients a greater degree overlap rheumatological symptoms an element systemic sclerosis (PSS) later develop severe disease....
The characteristic ability of rat uteri to take up tritiated estradiol in vitro or retain previously incorporated either vivo is destroyed by treating the tissue with various sulfhydryl-blocking reagents. two radioactive estradiol-receptor complexes, observed uterine homogenates supernatant fraction and an extract nuclear fraction, respectively, are disrupted brief exposure organic mercurials cold. Sulfhydryl groups receptor substances apparently play a vital role binding, perhaps indirectly...
One objection to xenotransplantation is that it will require the large-scale breeding, raising and killing of genetically modified pigs. The pigs need be raised in designated pathogen-free facilities undergo a range medical tests before having their organs removed being euthanised. As result, they have significantly shortened life expectancies, experience pain suffering subject degree social environmental deprivation. To minimise impact these factors, we propose following option for...
With decades of pre-clinical studies culminating in the recent clinical application xenotransplantation, it would appear timely to provide recommendations for operationalizing oversight xenotransplantation trials. Ethical issues with have been described decades, largely centering on animal welfare, risks posed recipient, and public health by potential spread xenozoonosis. Much less attention has given considerations relating potentially elevated faced those who may care or otherwise close...
Abstract Background Clinical trials of xenotransplantation (XTx, ie, cross‐species transplantation, specifically the transplantation genetically engineered pig organs into human recipients) are due to start within a few years. Methods Five focus groups were conducted in April‐May 2019, among local religious leaders (N = 10), organ procurement staff/administrators 5), patients and parents who may need an transplant or recipients 9), businesspersons community 3). Groups audio‐recorded,...
Clinical trials of kidney xenotransplantation are being considered in the United States. Before this novel procedure can take place, investigators will have to obtain approval from institutional review board. The consent form that be used for such a trial and receive board complex. Informed consent—the process by which research participant provides his/her permission participate clinical trial—is staple most commonly is physical document. In case with uncertain benefits risks population...
Abstract Preclinical xenotransplantation research using genetically engineered pigs has begun to show some promising results and could one day offer a scalable means of addressing organ shortage. While it is fundamental tenet ethical human subject that participants have right withdraw from once enrolled, several scholars argued the xenotransplant should be suspended because public health risks posed by xenozoonotic transmission. Here, we present comprehensive critical evaluation claim...
Xenotransplantation has the potential to alter U.S. transplant system in profound ways. However, this emerging "spare parts" solution spearheaded by biotechnology companies raises concerns about its impact on organ shortage, healthcare systems, population health, and health inequalities. We contend that xenotransplantation may have limited benefits improving could prove prohibitively expensive for many, divert resources away from proven public measures. Additionally, it carries risk of...
ABSTRACT Religious viewpoints have been shown to influence the ways in which many persons approach medical decision‐making and noted as a potential barrier xenotransplantation acceptance. This study sought explore how attitudes toward differ among various religious beliefs. A national Likert‐scale survey was conducted 2023 with representative sample United States. belief self‐reported. Regression analysis used identify associations hesitations about xenotransplantation. Five thousand eight...
This article examines use of the US Food and Drug Administration's (FDA's) expanded access pathway to permit cardiac xenotransplants. first argues that, although data are collected from xenotransplant surgeries authorized through FDA's pathway, uses preclinical trial do not align with stated aims access. also that potential risks xenotransplantation merit greater caution than posed by devices it is unclear how about such regarded operationalized during authorization processes.
Fervent attention was paid to what is coined dual-use research (DUR), or that can both benefit and harm humanity, of concern (DURC), a particular subset DUR reasonably anticipated be safety security if misapplied. The aim this paper not reiterate the challenges DURC governance but look at new turn in DURC, namely posed by use artificial intelligence (AI) pharmaceutical development. This important, as AI increasingly being used for development industry. There growing recognition there dearth...
Twelve cotton textile workers were studied: (1) to compare standard measures of volume and expiratory flow, maximal flow (MEFV) curves, closing (CV), capacity (CC) In detection airway narrowing with dust exposure; (2) evaluate the response arterial blood gases (3) measure changes in leukocytes peripheral secretions; (4) assess temporal relationships correlations between measures. Change (FEV1) most consistently significantly discriminated control exposures. [Vdot]max50%FVC was a more...
Scientific advancements are occurring in cardiac xenotransplantation (XTx). However, there have been religious and social concerns surrounding this allotransplantation alternative. The purpose of study was to explore the acceptance XTx among stakeholders congenital heart disease (CHD) community.A Likert-scale anonymous survey distributed physicians nurses who care for children with CHD parents CHD. Psychosocial clinical attitudes were compared across all groups identify differences,...
Previous studies have shown that ozone in low concentration vivo depresses the activity of alveolar macrophage acid phosphatase, lysozyme, and β-glucuronidase. In present studies, rabbit macrophages were held tissue culture as a monolayer exposed to various concentrations when covered by only film media. This approach eliminated recovery mixed population cells from lung possible influx response noxious agent. Ozone moderately concentration, 2 ppm, depressed lysosomal hydrolases. There was...
The osmotic fragility of alveolar macrophages recovered from ozone-exposed rabbits was determined, using a fragiligraph. Lung lavage resulted in smaller recoveries lung cells exposed to 10 ppm ozone for three hours, and the percentage decreased. Chronic low-dose exposures week did not affect total number recoverable but result increases neutrophils. average time minutes (± standard deviation) complete lysis control 33.0 ± 6.,5 24.0 2.2 (P < 0.05) acute 10-ppm cellsm Complete times chronic 2...
Abstract Clinical trials of xenotransplantation (XTx) may start in coming years. Religious views have been mentioned as possible barriers to XTx acceptance. While there reports on perspectives theologians regard XTx, no report has studied the community religious leaders. A focus group was conducted with a sample members following faith groups: Islam, Catholicism, and Protestantism. Qualitative content analysis performed identify interpretive themes. Four themes emerged. Participants were...