A5075258210- Xenotransplantation and immune response
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Animal Genetics and Reproduction
- Thermoregulation and physiological responses
- Cardiac Structural Anomalies and Repair
- Virus-based gene therapy research
- Obesity, Physical Activity, Diet
- Cardiac and Coronary Surgery Techniques
- T-cell and B-cell Immunology
- Organ and Tissue Transplantation Research
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- HIV-related health complications and treatments
- Viral Infections and Immunology Research
- Bone health and osteoporosis research
- Anesthesia and Neurotoxicity Research
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Antiplatelet Therapy and Cardiovascular Diseases
Massachusetts General Hospital
2004-2025
Harvard University
1990-2025
Mass General Brigham
2024
University of Maryland, Baltimore
2013-2023
VA Maryland Health Care System
2014-2023
University of Fribourg
2023
UCLouvain
2023
W. L. Gore & Associates (Germany)
2023
Terumo (Japan)
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
This study tested the hypothesis that body mass index (BMI) is representative of fatness independent age, sex, and ethnicity. Between 1986 1992, authors studied a total 202 black 504 white men women who resided in or near New York City, were ages 20–94 years, had BMIs 18–35 kg/m2. Total fat, expressed as percentage weight (BF%), was assessed using four-compartment composition model does not rely on assumptions known to be ethnicity dependent. Statistically significant age dependencies...
Gallagher, Dympna, Marjolein Visser, Ronald E. De Meersman, Dennis Sepúlveda, Richard N. Baumgartner, Pierson, Tamara Harris, and Steven B. Heymsfield. Appendicular skeletal muscle mass: effects of age, gender, ethnicity. J. Appl. Physiol. 83(1): 229–239, 1997.—This study tested the hypothesis that mass is reduced in elderly women men after adjustment first for stature body weight. The was evaluated by estimating appendicular with dual-energy X-ray absorptiometry a healthy adult cohort. A...
Skeletal muscle loss or sarcopenia in aging has been suggested cross-sectional studies but not shown elderly subjects using appropriate measurement techniques combined with a longitudinal study design. Longitudinal skeletal mass changes after age 60 yr were investigated independently living, healthy men ( n = 24) and women 54; mean 73 yr) ± SD follow-up time of 4.7 2.3 yr. Measurements included regional mass, four additional lean components (fat-free body cell total water, bone mineral),...
Abstract Preventing xenograft rejection is one of the greatest challenges transplantation medicine. Here, we describe a reproducible, long-term survival cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express human complement regulatory protein CD46 and thrombomodulin ( GTKO.hCD46.hTBM ), that were transplanted into baboons. Our immunomodulatory drug regimen includes induction with anti-thymocyte globulin αCD20 antibody, followed by maintenance mycophenolate...
To determine the body composition differences across age, 133 men with chronic spinal cord injury (SCI) (66 tetraplegia, 67 paraplegia) were compared an age-, height-, and ethnicity-matched able-bodied male reference population (n = 100) using two different dual-energy X-ray absorptiometry densitometers. The effects of duration injury, level, completeness lesion analyzed in SCI population. Independent total regional lean mass lower fat was higher persons controls. group 13 +/- 1% (means SE)...
Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune stromal cells contribute atrial fibrillation. Single-cell transcriptomes from human atria documented inflammatory monocyte
Objective: Recent studies have documented alterations in body fat distribution that been associated with protease inhibitor therapy. We compared composition, including measurements of distribution, 96 HIV-infected subjects studied since January 1996 (current HIV), seen prior to (previous and healthy controls. Design: Retrospective cross-sectional matched by gender, race, age, height. Methods: Body weight, height, cell mass whole-body counting 40K plus fat, fat-free mass, anthropometry were...
B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together an effort to prolong xenogeneic compared allogeneic skin graft survival. Mice anti-CD4 antibody showed prolonged survival of monkey rabbit even after they had rejected whole MHC-disparate mouse skin. Furthermore, the addition cyclosporine was synergistic prolonging These results suggest that cell-mediated response antigens is especially dependent on CD4+ lymphocytes, a feature shared by minor...
This study investigated metabolic and nutritional factors in association with athletic menstrual dysfunction (AMD). Three groups of women were studied: amenorrheic runners (amenorrheic), eumenorrheic (eumenorrheic), sedentary controls (sedentary). Amenorrheic similar age, weight, percent body fat by hydrodensitometry, training pace mileage, best 10 km race time, years running, maximal oxygen consumption. When adjusted for weight or fat-free mass analysis covariance, RMR was significantly...
There is a conflict in previous studies with regard to the relation between adipose tissue mass and total body fluid distribution. This study tested hypothesis that obesity accompanied by an increase extracellular-to-intracellular ratio above observed nonobese subjects. Extracellular was evaluated obese (n = 39) 26) healthy women, using two different dilution volumes, 35SO4 [extracellular water (ECW)] 24NaCl [exchangeable sodium (Nae)]. Intracellular (ICW 3H2O volume-ECW) potassium (TBK; 40K...
Peak exercise oxygen consumption (Vo2), a noninvasive index of peak cardiac output (CO), is widely used to select candidates for heart transplantation. However, Vo2 can be influenced by noncardiac factors such as deconditioning, motivation, or body composition and may yield misleading prognostic information. Direct measurement the CO response avoid this problem more accurately predict prognosis.Hemodynamic ventilatory responses maximal treadmill were measured in 185 ambulatory patients with...
An improved method of immunosuppression allows better immune function and prolongs the survival transplanted organs in nonhuman primates.
Xenotransplantation of genetically modified pig organs offers great potential to address the shortage human for allotransplantation. Rejection in Gal knockout (GTKO) pigs due elicited non-Gal antibody response required further genetic modifications donor and better control B-cell xenoantigens. We report significant prolongation heterotopic alpha Galactosyl transferase "knock-out" CD46 transgenic (GTKO.hCD46Tg) cardiac xenografts survival specific pathogen free baboons. Peritransplant...
Although the BMI is widely used as a measure of adiposity, it excess weight, and its association with body fatness may differ across racial or ethnic groups.To determine whether differences in between white, black, Hispanic, Asian children vary by BMI-for-age, accuracy overweight (BMI-for-age>or=Centers for Disease Control Prevention (CDC) 95th percentile) an indicator adiposity varies race/ethnicity.Total dual-energy X-ray absorptiometry (DXA) provided estimates %body fat among 1,104...
Based on cross-sectional analyses, it was suggested that hip circumference divided by height(1.5) -18 (the body adiposity index (BAI)), could directly estimate percent fat without the need for further correction sex or age. We compared prediction of fat, as assessed dual-energy X-ray absorptiometry (PBF(DXA)), BAI, BMI, and (waist hip) measurements among 1,151 adults who had a total scan DXA from 1993 through 2005. After accounting sex, we found PBF(DXA) related similarly to waist...