A5069529928- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Tissue Engineering and Regenerative Medicine
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Pain Management
- Congenital Heart Disease Studies
- Mesenchymal stem cell research
- Acute Kidney Injury Research
- Infectious Aortic and Vascular Conditions
- Hospital Admissions and Outcomes
- Surgical Simulation and Training
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Brigham and Women's Hospital
2025
Fistula Foundation
2020
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
Wroclaw University of Applied Informatics "Horizon"
2019
Faculty of 1000 (United States)
2019
Montreal Heart Institute
2017
Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune stromal cells contribute atrial fibrillation. Single-cell transcriptomes from human atria documented inflammatory monocyte
Background We previously demonstrated the successful tissue engineering and implantation of functioning autologous heart valves based on vascular-derived cells. Human marrow stromal cells (MSC) exhibit potential to differentiate into multiple cell-lineages can be easily obtained clinically. The feasibility creating engineered (TEHV) from MSC as an alternative cell source, impact a biomimetic in vitro environment differentiation was investigated. Methods Results were isolated, expanded...
The relation between ventricular arrhythmia and fibrosis in mitral valve prolapse (MVP) is reported, but underlying valve-induced mechanisms remain unknown. We evaluated the association abnormal MVP-related mechanics myocardial fibrosis, their with arrhythmia.
Pulmonary hypertension (pHTN) is associated with increased risk of mortality after mitral valve surgery for regurgitation. However, its association clinical outcomes in patients undergoing transcatheter repair (TMVr) a commercially available system (MitraClip) unknown.To assess the pHTN readmissions heart failure and 1-year all-cause TMVr.This retrospective cohort study analyzed 4071 who underwent TMVr MitraClip from November 4, 2013, through March 31, 2017, across 232 US sites Society...
In ischemic mitral regurgitation (IMR), ring annuloplasty is associated with a significant rate of recurrent MR. Ring size based on intertrigonal distance without consideration left ventricular (LV) size. However, LV an important determinant valve (MV) leaflet tethering before and after repair. We aimed to determine whether LV-MV mismatch (mismatch relative size) MR in patients IMR restrictive annuloplasty.Patients moderate or severe from the 2 Cardiothoracic Surgical Trials Network trials...
Outcomes of cardiac transplantation in patients undergoing reoperative sternotomy are often worse than primary transplants. However, the risks imposed by a prior sternotomy, left ventricular assist device (LVAD) or retransplantation have not been independently analysed.Using United Network for Organ Sharing (UNOS) database, retrospective propensity-matched cohort analysis was performed on 14 730 who received heart transplant between 2005 and 2017. Of 7365 underwent 4526 (61%) had previous...
Vascular-derived cells represent an established cell source for tissue engineering of cardiovascular constructs. Previously, isolation was performed by harvesting vascular structures prior to scaffold seeding. Marrow stromal (MSC) demonstrate the ability differentiate into multiple mesenchymal lineages and would offer alternative involving a less invasive technique. We studied feasibility using MSC as engineering.Human were isolated from bone marrow expanded in culture. Subsequently seeded...
Objective: To report mid-term results of stent-graft (SG) implantation in acute thoracic aortic rupture as alternative to conventional open surgery with its associated high morbidity and mortality rates. Methods: Out a series 69 patients undergoing SG since 1998, 24 (mean age 57±19 years, range 20–85-years-old) were treated on an emergency basis for hemorrhage control. The indication placement was traumatic 15 patients, type B dissection contained 3 penetrating ulcer periaortic hematoma...
Introduction Postoperative acute kidney injury (AKI) is a common complication in cardiac surgery. Levels of intravascular haemolysis are strongly associated with postoperative AKI and prolonged (>90 min) use cardiopulmonary bypass (CPB). Ferrous plasma haemoglobin released into the circulation acts as scavenger nitric oxide (NO) produced by endothelial cells. Consequently, vascular bioavailability NO reduced, leading to vasoconstriction impaired renal function. In patients cardiovascular...
Recent studies have linked mitral valve prolapse to localized myocardial fibrosis, ventricular arrhythmia, and even sudden cardiac death independent of regurgitation or hemodynamic dysfunction. The primary mechanistic theory is rooted in increased papillary muscle traction forces due prolapse, yet no biomechanical evidence exists showing forces. Our objective was evaluate the relationship between forces, leveraging advances ex vivo modeling technologies. We hypothesized that with limited...