A5000544616- Gut microbiota and health
- Animal Nutrition and Physiology
- Tryptophan and brain disorders
- Organ Transplantation Techniques and Outcomes
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Barrier Structure and Function Studies
- Probiotics and Fermented Foods
- Antimicrobial Peptides and Activities
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
- Adipose Tissue and Metabolism
- Agriculture Sustainability and Environmental Impact
- Dietary Effects on Health
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Angiogenesis and VEGF in Cancer
- Human Health and Disease
- Cardiac Ischemia and Reperfusion
- Antifungal resistance and susceptibility
- interferon and immune responses
- Inflammasome and immune disorders
- Neurological Disease Mechanisms and Treatments
- Healthcare and Venom Research
Nanjing University of Finance and Economics
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
China Agricultural University
2015-2024
Hebei Agricultural University
2023-2024
State Key Laboratory of Animal Nutrition
2024
Anhui Medical University
2024
University of Chinese Academy of Sciences
2024
Shuozhou Central Hospital
2024
The proinflammatory cytokine IL-1beta plays an important role in antifungal immunity; however, the mechanisms by which fungal pathogens trigger secretion are unclear. In this study we show that infection with Candida albicans is sensed Nlrp3 inflammasome, resulting subsequent release of IL-1beta. ability C. to switch from a unicellular yeast form into filamentous essential for activation as mutants incapable forming hyphae were defective their induce macrophage IL- 1beta secretion....
Abstract Dietary amino acids (AAs) are not only absorbed and metabolized by enterocytes but also available to the microbiota in gut mammals. In addition serving as materials for protein synthesis, AAs can act precursors numerous metabolic end products reactions involving intestinal mucosa microbiota. After penetrating epithelial barrier, microbial metabolites enter accumulate host circulatory system, where they sensed immune cells then elicit a wide range of biological functions via...
The study investigated the impact of dietary fibers on performance, fecal short-chain fatty acids, nutrient digestibility, and bacterial community in weaned piglets with control group (CON) supplementation 5% corn bran (CB), wheat (WB), or soybean hulls (SB). CB WB groups showed greater weight gain feed efficiency ( p < 0.05) comparison to CON SB groups. Fecal samples from CB, SB, contained butyrate levels than group. abundances Actinobacteria Firmicutes Fibrobacteres sample group, which...
Appropriate protein concentrations are essential for animals at certain stage. This study evaluated the effects of different percentages dietary restriction on intestinal health growing pigs. 18 barrows were randomly assigned to a normal (18%), low (15%) and extremely (12%) concentration group 30 days. Intestinal morphology permeability, bacterial communities, expressions distributions tight junction proteins, biomarkers stem cells (ISCs) chymous metabolites in ileum colon detected. The...
Abstract In recent years, the important role of gut microbiota in promoting animal health and regulating immune function livestock poultry has been widely reported. The issue problems causes significant economic losses each year. Probiotics postbiotics have developed as additives due to their beneficial effects balancing host microbiota, enhancing intestinal epithelial barrier, immunity, whole‐body metabolism. are composed complex ingredients, with different components compositions having...
Solid-state fermentation feed by Bacillus subtilis MA139 can reduce insoluble dietary fiber content in vitro and improve growth performance pigs. This study was aimed to investigate the effects of corn bran (CB) fermented B. on gut microbiota composition finishing A total 60 pigs were allocated into 3 treatments, each group received control (CON) diet, 10% CB (FCB) respectively. The treatment lasted 21 d. Growth nutrient digestibility evaluated. Fecal samples determined for bacterial...
To assess the impact of sanitation a living environment on gut microbiota and development immune system, we raised BALB/c mice under three distinct environmental conditions: specific pathogen-free animal room (SPF), general (XZ) farmhouse (JD). All other variables like diet, age, genetic background, physiological status original were controlled for in groups. Using high-throughput sequencing 16S rRNA gene, found that each mouse group had structure microbial community. Groups JD XZ harboured...
The effects of dimethyl fumarate (DMF) on mycotoxins and animal growth performance are well documented. However, its mechanism anti-mildew is still unknown. current study investigated how DMF detoxified the mycotoxin improved using BALB/c mice model, especially intestinal barrier function gut micro-ecology. Our also compared with ultraviolet radiation (UR) treatment, a traditional control (TC). results indicated that treatment had lower contents mycotoxin, better mucosal morphology (P <...
The composition of skeletal muscle fiber types affects the quality livestock meat and human athletic performance health. L-arginine (Arg), a semi-essential amino acid, has been observed to promote formation slow-twitch fibers in animal models. However, precise molecular mechanisms are still unclear. This study investigates role Arg mitochondrial function through mTOR signaling pathway. In vivo, 4-week C56BL/6J male mice were divided into three treatment groups fed basal diet supplemented...