A5101918684- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Advanced Drug Delivery Systems
- Polysaccharides and Plant Cell Walls
- X-ray Diffraction in Crystallography
- Analytical Chemistry and Chromatography
- Nanoplatforms for cancer theranostics
- MRI in cancer diagnosis
- Photochemistry and Electron Transfer Studies
- Prostate Cancer Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Porphyrin and Phthalocyanine Chemistry
- Drug-Induced Hepatotoxicity and Protection
- Pediatric Urology and Nephrology Studies
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- Traditional Chinese Medicine Analysis
- Zeolite Catalysis and Synthesis
- Advanced MRI Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Sphingolipid Metabolism and Signaling
- Microwave-Assisted Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Remote Sensing and Land Use
Hebei Agricultural University
2013-2024
Second Affiliated Hospital of Zhengzhou University
2021-2024
Zhengzhou University
2024
Hebei University of Technology
2022-2023
University of Minnesota
2016
The oral delivery of genistein (GEN) is hindered by its low bioavailability. tetramethylpyrazine (TMP or ligustrazine) faced with physical instability challenges due to high sublimation tendency. We tackled respective the two drugs forming a cocrystal. GEN-TMP cocrystal exhibits significantly reduced tendency than TMP and significant enhancement in both vitro release rate bioavailability rats GEN. Thus, cocrystallization simultaneously improves pharmaceutical properties parent drugs.
Highly soluble cocrystals can improve the bioavailability of poorly drugs by inducing supersaturation when absorption is limited drug dissolution. Enrofloxacin (ENR) a concentration-dependent fluoroquinolone antibacterial with poor solubility. In this study, two new ENR salts, 3,5-dihydroxybenzoic acid (ENR-3,5-DHBA) and 2,6-dihydroxybenzoic (ENR-2,6-DHBA·1/2H2O), were prepared, their physicochemical properties evaluated for suitability in formulation development. Results showed that...
Topical 5-fluorouracil (5FU) is clinically used for skin cancer. However, the penetration of 5FU low and marginal due to its poor permeability, leading limited efficacy cancer treatment. Cocrystal formation offers an opportunity improve permeability a drug without changing molecular structure. Herein, two cocrystals with lipophilic 6-hydroxy-2-naphthoic acid (5FU–6HNA, 1:1) 3-hydroxy-2-naphthoic (5FU–3HNA, 2:1) were obtained characterized. The solid-state density functional theory...
The objective of this study is to establish poultry liver injury model induced by (CCl 4 ) and seek effective hepatoprotective herbals for clinical application. Different doses CCl dissolved in vegetable oil (1 : 1, V/V were injected via pectoral muscle induce acute chickens. An herbal formula, Longyin decoction, was prepared hepatoprotection test on chicken models. pathologic changes the observed, activities ALT AST were, respectively, detected evaluate effects decoction successfully...
Qingdaisan (Formulated Indigo powder, QDS) are widely used for treatment of aphtha, sore throat and bleeding gums in China. The aim the study is to evaluate anti-inflammatory, antibacterial dental ulcer therapeutic effects QDS.Dimethylbenzene-induced ear edema test cotton pellet-induced granuloma were anti-inflammatory activities QDS on acute chronic inflammatory. healing time local pathologic changes assess ulcer. each component whole formulation determined by agar well diffusion assay....
Cocrystallization with saccharine (SAC) significantly improved photostability of dimetronidazole (DMZ), an veterinary antibiotic.
To overcome the poor solubility, permeability, and bioavailability of plant isoflavone daidzein (DAI), a novel salt DAI with anhydrous piperazine (PIP) was obtained based on cocrystallization strategy. The new DAI-PIP characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, optical microscopy. results showed that maximum apparent solubility (S
Tetramethylpyrazine (TMP) is used clinically to treat cardiovascular disease and ischemic cerebrocardial vascular disease. However, the high sublimation tendency of TMP leads its physical instability. In this study, we successfully synthesized comprehensively characterized four cocrystals formed by with cinnamic acid derivatives. These effectively mitigated TMP, demonstrating their potential for stabilizing active pharmaceutical ingredient. Through detailed density functional theory...
On the strength of new quantum impedance Lorentz oscillator (QILO) model, a charge-transfer method in molecular photon-absorption is proposed and imaged via numerical simulations 1- 2-photon-absorption (1PA 2PA) behaviors organic compounds LB3 M4 this paper. According to frequencies at peaks full width half-maximums (FWHMs) linear absorptive spectra two compounds, we first calculate effective numbers before after electronic transitions. Thus, obtain average dipole moments, i.e., 1.8728 ×...
The equal acid–base centers and their synergetic catalysis of ZrO 2 account for its high catalytic activity.