A5041657468- Diabetes Treatment and Management
- Advanced Sensor and Energy Harvesting Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- MXene and MAX Phase Materials
- Signaling Pathways in Disease
- Supramolecular Self-Assembly in Materials
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Gas Sensing Nanomaterials and Sensors
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
Air Force Medical University
2016-2025
North University of China
2022-2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2024
Jiamusi University
2024
Kunming Medical University
2023
Sichuan University
2021-2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2020-2022
Chongqing Medical University
2017
Glucagon-like peptide 1 (GLP-1) plays an important role in regulating bone remodeling, and GLP-1 receptor agonist shows a positive relationship with osteoblast activity. However, is not found osteoblast, the mechanism of on remodeling unclear. Here, we show that exendin-4 (Ex-4) promoted formation increased mass quality rat unloading-induced loss model. These functions were accompanied by increase number serum markers, while adipocyte was decreased. Furthermore, detected marrow stromal cells...
Abstract Ischemic stroke leads to neuronal damage induced by excitotoxicity, inflammation, and oxidative stress. Astrocytes play diverse roles in ischemia‐induced autophagy is critical for maintaining astrocytic functions. Our previous studies showed that the activation of G protein‐coupled receptor 30 (GPR30), an estrogen membrane receptor, protected neurons from excitotoxicity. However, role GPR30 neuroprotection remained unclear. In this study, we found G1 (GPR30 agonist) wild‐type mice...
Abstract Flexible pressure sensors possess superior conformal ability, great flexibility, and strong biocompatibility than conventional silicon-based sensors, thereby widely used in electronic skin, wearable devices, robotic tactile sensing, among other fields. However, flexible are still limited by many challenges related to extended linearity high sensitivity. In this paper, MXene with a loose layered structure was employed fabricate high-performance piezoresistive comprising...
Methicillin-resistant Staphylococcus aureus (MRSA) infections are becoming increasingly difficult to treat, owing acquired antibiotic resistance. The emergence and spread of MRSA limit therapeutic options require new strategies, including novel MRSA-active antibiotics. Filamentous temperature-sensitive protein Z (FtsZ) is a highly conserved bacterial tubulin homologue that essential for controlling the cell division process in different species S. aureus. We conjugated locked nucleic acid...
Herein, we described a highly regio- and enantioselective Friedel–Crafts alkylation of aniline derivatives with in situ generated ortho-quinone methides enabled by chiral phosphoric acid, furnishing wide range enantioenriched triarylmethanes bearing three similar benzene rings high yields (up to 98%) excellent stereoselectivities 98% ee). Furthermore, the large-scale reactions diversified transformations product demonstrate practicality protocol. Density functional theory calculations...
Neutrophil infiltration has been linked to worse clinical outcomes after ischemic stroke. Microglia, a key type of immune-competent cell, engage in cross-talk with the infiltrating immune cells inflamed brain area, yet molecular mechanisms involved remain largely unexplored. In this study, we investigated how canonical transient receptor potential 1 (TRPC1) modulated neutrophil male mouse cerebral ischemia and reperfusion injury (CIRI) models. Our findings revealed notable upregulation TRPC1...
Diabetes is a major risk factor for the development of stroke. Glucagon-like peptide-1 receptor (GLP-1R) agonists have been in clinical use treatment diabetes and also reported to be neuroprotective ischemic The quinoxaline 6,7-dichloro-2-methylsulfonyl-3-N-tert- butylaminoquinoxaline (DMB) an agonist allosteric modulator GLP-1R with potential increase affinity GLP-1 its receptor. aim this study was evaluate effects DMB on transient focal cerebral ischemia. In cultured cortical neurons,...
Dose-response and nonlinear relationships of cigarette exposure with sleep disturbances depression are warranted, the potential mechanism sex hormones in such associations remains unclear.
Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-related modifier (SUMO)ylation. Our findings suggest a notable increase in microglial SUMOylation within both middle artery occlusion (MCAO/R) model vitro oxygen-glucose deprivation/regeneration...
Abstract Transient receptor potential canonical (TRPC) channels are the most prominent nonselective cation involved in various diseases. However, function, clinical significance, and molecular mechanism of TRPCs colorectal cancer (CRC) progression remain unclear. In this study, we identified that TRPC1 was major variant gene TRPC family CRC patients. upregulated tissues compared with adjacent normal high expression associated more aggressive tumor poor overall survival. knockdown inhibited...
Flexible pressure sensor based on Ti 3 C 2 T x -MXene/PET textiles enable stable measurement of pulse signals, which is significant for wearable smart medical devices in the future.
Background/Aims: The synthesis and degradation processes involved in bone remodeling are critically regulated by osteoblasts osteoclasts. GLP-1 receptor agonist Exendin-4 is beneficial for osteoblast differentiation increases the number of osteoblasts. Methods: We constructed an ovariectomized model to evaluate impact on formation osteoporosis. A macrophage-depleted was also created investigate effect macrophages formation. Thirty-two female WT C57BL/6 mice (aged 3 months) were randomly...
DNA methylation analysis holds great promise in the whole process management of cancer early screening, diagnosis, and prognosis monitoring. Nevertheless, accurate detection target methylated DNA, especially its ratio genome, remains challenging. Herein, we report for first time an integrated strategy target-induced nanoparticle-coupling site-specific base oxidation damage with assistance well-designed nanosensors. The ultrahigh sensitivity detecting as low 32 × 10–17 M high specificity...
Flexible wearable sensors have been widely used in medical detection. In the clinic, pulse and body temperature are two critical vital signs. Continuous real-time monitoring is of great significance to human health. Herein, a sensor based on wood sponge designed detect biological signals fabricated by chemical treatment freeze-drying. After decorating porous with single-walled carbon nanotubes (SWCNTs) poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS), can precisely...
High-performance flexible pressure sensors provide comprehensive tactile perception and are applied in human activity monitoring, soft robotics, medical treatment, human-computer interface. However, these require extensive nano-architectural design complicated manufacturing time-consuming. Herein, a highly sensitive, piezoresistive sensor is designed fabricated, consisting of three main parts: the randomly distributed microstructure on T-ZnOw/PDMS film as top substrate, multilayer...